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Savlevich E.L.

Training Scientific Medical Center of the Russian Federation Presidential Administration, Moscow, Russia, 121359

Kozlov V.S.

Kafedra otorinolaringologii FGBU UNMTs UD Prezidenta RF

Zharkykh M.A.

Polyclinic №5 of Department for Presidential Affairs of the Russian Federation, Moscow, Russia, 119121

A study of the efficacy and safety of new cephalosporin in the treatment of acute bacterial rhinosinusitis

Authors:

Savlevich E.L., Kozlov V.S., Zharkykh M.A.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2016;81(6): 73‑77

DOI: 10.17116/otorino201681673-77

Read: 5925 times

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Table of contents

A STUDY OF THE EFFICACY AND SAFETY OF NEW CEPHALOSPORIN IN THE TREATMENT OF ACUTE BACTERIAL RHINOSINUSITIS
A STUDY OF THE EFFICACY AND SAFETY OF NEW CEPHALOSPORIN IN THE TREATMENT OF ACUTE BACTERIAL RHINOSINUSITIS

To cite this article:

Savlevich EL, Kozlov VS, Zharkykh MA. A study of the efficacy and safety of new cephalosporin in the treatment of acute bacterial rhinosinusitis. Russian Bulletin of Otorhinolaryngology. 2016;81(6):73‑77. (In Russ.)
https://doi.org/10.17116/otorino201681673-77

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Acute rhinosinusitis is leading in frequency of antibiotic prescribing all over the world. At the same time the problem of antibiotic resistance and safety of antimicrobial drugs becomes more relevant and international. The article describes the basic mechanisms of bacterial resistance and growth of side effects when using macrolides, respiratory fluoroquinilones and β-lactam antibiotics of different types. Formation of IgE-mediated cephalosporin allergy is associated with the side R1 chain. The R1 structure of cephalosporins I and II generations is similar to penicillins, thus creating conditions for cross-allergy progression. R1 of cephalosporins III and IV generations is represented by a qualitatively different chemical compound (aminothiazol-oxime group) that increases the level of tolerance to these antibiotic types. The data of surveillance study are given to evaluate the efficacy and safety of the new drug Spectracef (active substance is cephalosporin of III generation Cefditoren) when treating acute bacterial rhinosinusitis on an outpatient basis.

Keywords:

acute rhinosinusitis
antibiotics
cephalosporins
penicillins
allergy
resistance
side effects

Authors:

Savlevich E.L.

Training Scientific Medical Center of the Russian Federation Presidential Administration, Moscow, Russia, 121359

Kozlov V.S.

Kafedra otorinolaringologii FGBU UNMTs UD Prezidenta RF

Zharkykh M.A.

Polyclinic №5 of Department for Presidential Affairs of the Russian Federation, Moscow, Russia, 119121

Close metadata

References:

  1. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, Georgalas C, Goossens H, Harvey R, Hellings P, Hopkins C, Jones N, Joos G, Kalogjera L, Kern B, Kowalski M, Price D, Riechelmann H, Schlosser R, Senior B, Thomas M, Toskala E, Voegels R, Wang de Y, Wormald PJ. European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl. 2012;50(23):1-298. doi: 10.2500/ajra.2013.27.3925
  2. Venekamp RP, Rovers MM, Verheij TJM, Bonten MJM, Sachs APE. Treatment of acute rhinosinusitis: discrepancy between guideline recommendations and clinical practice. Family Practice. 2012;29:706-712. doi: 10.1093/fampra/cms022
  3. Masood A, Moumoulidis I, Panesar J. Acute rhinosinusitis in adults: an update on current management. Postgrad Med J. 2007;83(980):402-408. doi: 10.1136/pgmj.2006.054767
  4. Brook I/ Microbiology of sinusitis. Proc Am Thorac Soc. 2011;8(1):90-100. doi: 10.1513/pats.201006-038RN
  5. Svistushkin VM, Grinev IA, Stetsuk OU, Andreeva IV. Recommendations on observation of adult patients suffering from acute rhinosinusitis: is the consensus achievable? Lechashhij vrach. 2012;11:90-96. (In Russ.).
  6. Wang JH, Kwon HJ, Jang YJ. Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously. The Laryngoscope. 2009;119(7):1406-1411. doi: 10.1002/lary.20498
  7. Kozlov RS. Pnevmokokki: uroki proshlogo — vzglyad v budushchee. Smolensk: МаkМАХ; 2010. (In Russ.).
  8. Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf. 2014;5(6):229-241. doi: 10.1177/2042098614554919.
  9. Strachunskij LS, Belousov UB, Kozlov SN eds. Prakticheskoe rukovodstvo po antiinfektsionnoi khimioterapii. Smolensk: МаkМАХ; 2007. (In Russ.).
  10. Тristram S, Jacobs MR, Appelbaum PC. Antimicrobial resistance in Haemophilus influenzae. Clin Microbiol Rev. 2007;20:368-389. doi: 10.1128/CMR.00040-06
  11. Gotoh K, Qin L, Watanabe H, Watanabe K. Prevalence of Haemophilus influenzae with resistant genes isolated from young children with acute lower respiratory tract infections in NhaTrang, Vietnam. J Infect Chemother. 2008;14:349-353. doi: 10.1007/s10156-008-0632-1
  12. Chow AW, Benninger MS, Brook I, Brozek JL, Goldstein CEJ, Hicks LA, Pankey GA, Seleznick M, Volturo G, Wald ER. IDSA clinic.al practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis. 2012;54(8):72-112. doi: 10.1093/cid/cis370
  13. Mizernitskii YuV, Sorokina EV. Sovremennye podkhody k diagnostike, lecheniyu i profilaktike ostryh respiratornyh zabolevanii u detei (ORI, bronkhity i pnevmonii). Pulmonologiya detskogo vozrasta: problemy i resheniya. 2013;13:121-137. (In Russ.).
  14. Kozlov RS. Sovremennye ingibitorozashchishchennye penitsilliny v praktike pediatra. Pulmonologiya detskogo vozrasta: problemy i resheniya. 2009;9:78-82. (In Russ.).
  15. Hussaini SH, O’Brien CS, Despott EJ, Dalton HR. Antibiotic therapy: a major cause of drug-induced jaundice in southwest England. Eur J Gastroenterol Hepatol. 2007;19:15-20. doi: 10.1097/01.meg.0000250581.77865.68
  16. Padd S, Sanchez М, Akhtar А, Boyer J. Drug induced cholestasis Hepatology. 2011;53(4):1377-1387. doi: 10.1002/hep.24229
  17. Andrade RJ, Tulkens PM. Hepatic safety of antibiotics used in primary care. J Antimicrob Chemother. 2011;66(7):1431-1446. doi: 10.1093/jac/dkr159
  18. Schalek P, Petrás P, Klement V, Hahn A. Short term antibiotics treatment in patients with nasal polyps and enterotoxins producing Staphylococcus aureus strains. Eur Arch Otorhinolaryngol. 2009;266(12):1909-1913. doi: 10.1007/s00405-009-1049
  19. Kozlov RS, Sivaya OV, Kretchikova OI, Ivanchik NV. Antimicrobial Resistance of Streptococcus pneumonia in Russia over the 1999—2009: Results of Multicenter Prospective Study PEHASus. Clinical Microbiology and Antimicrobial Chemotherapy. 2010;12(4):329-334. (In Russ.).
  20. Saukkonen JJ, Cohn DL, Jasmer RM, Schenker S, Jereb JA, Nolan CM, Peloquin CA, Gordin FM, Nunes D, Strader DB, Bernardo J, Venkataramanan R, Sterling TR. An official ATS statement: hepatotoxicity of antituberculosis therapy. Am J Respir Crit Care Med. 2006;174:935-952. doi: 10.1164/rccm.200510-1666ST
  21. Leitner JM, Graninger W, Thalhammer F. Hepatotoxicity of antibacterials: pathomechanisms and clinical. Infection. 2010;38(1):3-11. doi: 10.1007/s15010-009-9179-z
  22. Guo D, Cai Y, Chai D, Liang B, Bai N, Wang R. The cardiotoxicity of macrolides: a systematic review. Pharmazie. 2010;65(9):631-640. doi: 10.1691/ph.2010.0644
  23. Karageorgopoulos DE, Giannopoulou KP, Grammatikos AP, Dimopoulos G, Falagas ME. Fluoroquinolones compared with beta- lactam antibiotics for the treatment of acute bacterial sinusitis a meta-analysis of randomized controlled trials. CMAJ. 2008;178:845-854. doi: 10.1503/cmaj.071157
  24. Iannini P. Quinolone-induced QT interval prolongation: a not-so-unexpected class effect. Journal of Antimicrobial Chemotherapy. 47(6):893-894. doi: 10.1093/jac/47.6.893-a
  25. Stetsiouk OU, Andreeva IV, Kolosov AV, Kozlov RS. Safety and efficacy of antibiotics used in outpatient setting. Consilium medicum. 2011;13:37-46. (In Russ.).
  26. Adikwu E, Deo O. Fluoroquinolones reported hepatotoxicity. Pharmacology Pharmacy. 2012;3(3):328-336. doi: 10.4236/pp.2012.33044
  27. Lewis T, Cook J. Guide for Athletes and Sports Clinicians and a Systematic Review of the Literature. J Athl Train. 2014;49(3):422-427. doi: 10.4085/1062-6050-49.2.09
  28. Yamada M, Watanabe T, Miyara T. Crystal structure of cefditoren complexed with Streptococcus pneumoniae penicillin-binding protein 2X: structural basis for its high antimicrobial activity. Antimicrob Agents Chemother. 2007;51:45-50. doi: 10.1128/AAC.00743-07
  29. Trubiano JA, Cairns KA. The prevalence and impact of antimicrobial allergies and adverse drug reactions at an Australian tertiary centre. BMC Infectious Diseases. 2015;15(1):572. doi: 10.1186/s12879-015-1303-3
  30. Campagna JD, Bond MC, Schabelman E, Hayes BD.The use of cephalosporins in penicillin-allergic patients: a literature review. J Emerg Med. 2012;42(5):612-620. doi: 10.1016/j.jemermed.2011.05.035
  31. Pichichero ME. Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift. Diagn Microbiol Infect Dis. 2007;57(3):13-18. doi: 10.1016/j.diagmicrobio.2006.12.004
  32. Kelkar P, Li J. Cephalosporin allergy. N Engl J Med. 2001;385:804-809. doi: 10.1056/NEJMra993637
  33. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD, Schwartz RH, Thomas PA, Tunke DE. The diagnosis and management of acute otitis media. Pediatrics. 2013;131(3):964-999. doi: 10.1542/peds.2012-3488
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