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Malakhova A.I.

Smolensk Regional Clinical Hospital

Strahov V.V.

Yaroslavl State Medical University

Kovaleva Y.D.

Smolensk State Medical University

Malakhova Y.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Objective functional monitoring of retinoprotective treatment in diabetic retinopathy

Authors:

Malakhova A.I., Strahov V.V., Kovaleva Y.D., Malakhova Y.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2024;140(1): 45‑56

DOI: 10.17116/oftalma202414001145

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To cite this article:

Malakhova AI, Strahov VV, Kovaleva YD, Malakhova YA. Objective functional monitoring of retinoprotective treatment in diabetic retinopathy. Russian Annals of Ophthalmology. 2024;140(1):45‑56. (In Russ.)
https://doi.org/10.17116/oftalma202414001145

Подписка 2025 (Russian Annals of Ophthalmology)
 
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In recent years, there has been a growing interest in the contribution of neuroretinal degeneration to the pathogenesis of diabetic retinopathy (DR).

PURPOSE

This study assesses the effect of the drug Retinalamin on the functional state of the retina in patients with DR using the Diopsys NOVA Vision Testing System that utilizes electrophysiological (EP) technology.

MATERIAL AND METHODS

The study included patients with type 1 and 2 diabetes mellitus (DM) with DR of any stage without macular edema. Patients underwent standard ophthalmological examination and objective functional examination of the retina using the Diopsys NOVA Vision Testing System. The control group consisted of patients with type 1 and 2 DM with DR who did not receive Retinalamin.

RESULTS

Significant changes in pattern electroretinography and flash electroretinography parameters were recorded in patients who received a course of Retinalamin. Two clinical examples are presented, which can be designated as the first experience of objective functional monitoring of treatment of patients with DR with Retinalamin.

CONCLUSION

Retinoprotective therapy is necessary already at the early stages of DR. Electroretinography is an objective tool for functional analysis of the earliest changes in retinal cells in DR. It is necessary to use the identified “therapeutic” window for the appointment of retinoprotective agents.

Keywords:

diabetic retinopathy
neurodegeneration
electrophysiology
Retinalamin
Diopsys

Authors:

Malakhova A.I.

Smolensk Regional Clinical Hospital

Strahov V.V.

Yaroslavl State Medical University

Kovaleva Y.D.

Smolensk State Medical University

Malakhova Y.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

13.12.2023

Accepted:

25.01.2024

List of references:

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