Modern prerequisites for creating a collagen-based artificial analogue of the corneal stroma

Andreev A.Yu.; Osidak E.O.; Avetisov S.E.; Voronin G.V.; Andreeva N.A.; Agaeva L.M.; Yu Y.; Domogatskiy S.P.

doi:https://doi.org/10.17116/oftalma2022138052253

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Abstract:

Despite the fact that various collagen biomaterials have been actively used in ophthalmology for more than 30 years, the problem of creating a material that could replace the donor cornea have not been solved. Recent advances in the field of tissue engineering and regenerative medicine have shifted the focus of approaches to solving the problem of creating an artificial cornea towards laying conditions for the restoration of its specific layers through mechanisms of its own cellular regeneration. In this regard, extracellular matrices based on collagen are gaining popularity. This review discusses general limitations and advantages of collagen for creating an artificial cornea.

Keywords:

ophthalmology

artificial cornea

keratoplasty

collagen

Authors:

Andreev A.Yu.

Krasnogorsk City Hospital No 1;
Imtek LLC

Osidak E.O.

Imtek Co. Ltd.;
National Medical Research Center of Cardiology named after academician E.I. Chazov

ORCID: 0000-0001-5289-8316

Avetisov S.E.

Krasnov Research Institute of Eye Disease;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-7115-4275

Voronin G.V.

Research Institute of Eye Diseases

SPIN RSCI: 4300-0648
Scopus AuthorID: 7005174792
ResearcherID: AAO-7850-2021
ORCID: 0000-0002-5769-6593

Andreeva N.A.

Research Institute of Eye Diseases

ORCID: 0000-0001-7329-5725

Agaeva L.M.

Research Institute of Eye Diseases

Yu Y.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Domogatskiy S.P.

Imtek Co. Ltd.;
National Medical Research Center of Cardiology named after academician E.I. Chazov

Received:

29.10.2021

Accepted:

19.11.2021

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References:

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