Changes in precorneal tear film and ocular surface in keratoconic patients after corneal collagen cross-linking

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The article reviews the current available data on the signs and symptoms of dry eye syndrome (DES) in patients with keratoconus (KC), describes the clinical features of DES in KC patients and the morphological features of this type of keratectasia that lead to manifestations of the «dry eye», and highlights the risk factors, consequences of therapeutic measures, concomitant ophthalmological and general somatic diseases that contribute to the development of DES in KC.

Keywords:

keratoconus

dry eye syndrome

precorneal tear film

Schirmer test

Norn test

tear film break-up time

tear secretion

corneal collagen cross-linking

rigid contact lenses

implantation of intrastromal corneal segments and rings

Authors:

Bubnova I.A.

Research Institute of Eye Diseases

Sarkisova K.G.

Research Institute of Eye Diseases

Received:

30.06.2021

Accepted:

26.10.2021

List of references:

Alio JL. Keratoconus: Recent advances in diagnosis and treatment. Springer; 2016.
Barbara A, Rabinowitz YS. Textbook on keratoconus: New insights. JP Medical Ltd; 2011.
Sinjab MM. Quick guide to the management of keratoconus. Springer; 2011.
Wang M, Swartz TS. Keratoconus and keratoectasia: prevention, diagnosis, and treatment. SLACK Inc.; 2010.
Zadnik K, Barr JT, Edrington TB, Everett DF, Jameson M, McMahon TT, Shin JA, Sterling JL, Wagner H, Gordon MO. Baseline findings in the collaborative longitudinal evaluation of keratoconus (CLEK) study. Invest Ophthalmol Vis Sci. 1998;39(13):2537-2546.
Egorova GB, Fedorov AA. Keratoconus and dry eye syndrome. RMJ. Clinical ophthalmology = RMZh. Klinicheskaya oftal’mologiya. 2004;5(1):29-31. (In Russ.).
Lobanova OS, Slominskyi YuB. Early diagnostics of symptom «dry eye» at keratoconus by method meniscusmetry. Vestnik OGU. 2012;12(148):122-127. (In Russ.).
Dogru M, Karakaya H, Ozçetin H, Ertürk H, Yücel A, Ozmen A, Baykara M, Tsubota K. Tear function and ocular surface changes in keratoconus. Ophthalmology. 2003;110(6):1110-1118. https://doi.org/10.1016/S0161-6420(03)00261-6
Carracedo G, Recchioni A, Alejandre-Alba N, Martin-Gil A, Crooke A, Jimenez-Alfaro Morote I, Pintor J. Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study. Curr Eye Res. 2015;40(11):1088-1094. https://doi.org/10.3109/02713683.2014.987871
Dienes L, Kiss HJ, Perényi K, Nagy ZZ, Acosta MC, Gallar J, Kovács I. Corneal Sensitivity and Dry Eye Symptoms in Patients with Keratoconus. PLoS One. 2015;10(10):e0141621. https://doi.org/10.1371/journal.pone.0141621
Awad KS, Aljarousha MA. Comparison of dry eye parameters between keratoconus patients and control subjects in Gaza Strip, Palestine. IUG J Nat Stud. Peer-reviewed J Islamic University-Gaza. 2017;25(2):325-328.
Recalde JI, Acera A, Rodríguez-Agirretxe I, Sánchez-Tena MA, San-Cristóbal J, Durán JA. Ocular surface disease parameters after collagen cross-linking for keratoconus. Cornea. 2017;36(2):148-152. https://doi.org/10.1097/ICO.0000000000001085
Taneri S, Oehler S, Asimellis G, Kanellopoulos AJ. Influence of Corneal Cross-linking for Keratoconus on Several Objective Parameters of Dry Eye. J Refract Surg. 2013;29(9):612-616. https://doi.org/10.3928/1081597X-20130819-02
Carracedo G, González-Méijome JM, Martín-Gil A, Carballo J, Pintor J. The influence of rigid gas permeable lens wear on the concentrations of dinucleotides in tears and the effect on dry eye signs and symptoms in keratoconus. Cont Lens Anterior Eye. 2016;39(5):375-379. https://doi.org/10.1016/j.clae.2016.04.009
Elgin CY, Iskeleli G, Aydin O. Effects of the rigid gas permeable contact lense use on tear and ocular surface among keratoconus patients. Lens Anterior Eye. 2018;41(3):273-276. https://doi.org/10.1016/j.clae.2017.12.013
Zhang XH, Li X. Effect of rigid gas permeable contact lens on keratoconus progression: a review. Int J Ophthalmol. 2020;13(7):1124-1131. https://doi.org/10.18240/ijo.2020.07.17
Carracedo G, Recchioni A, Alejandre-Alba N, Martin-Gil A, Batres L, Jimenez-Alfaro Morote I, Pintor J. Signs and Symptoms of Dry Eye in Keratoconus Patients Before and After Intrastromal Corneal Rings Surgery. Curr Eye Res. 2017;42(4):513-519. https://doi.org/10.1080/02713683.2016.1200098
Constantin MM, Corbu C, Potop V, Burcel M, Mocanu S, Ionita G. Evaluation of Dry Eye Symptomatology at Patients with Keratoconus. Revista de Chimie. 2019;70(1):92-95. https://doi.org/10.37358/RC.19.1.6858
Gomes JAP, Tan D, Rapuano CJ, Belin MW, Ambrósio R Jr, Guell JL, Malecaze F, Nishida K, Sangwan VS. Global consensus on keratoconus and ectatic diseases. Cornea. 2015;34(4):359-369. https://doi.org/10.1097/ICO.0000000000000408
Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK, Liu Z, Nelson JD, Nichols JJ, Tsubota K, Stapleton F. TFOS DEWS II Definition and Classification Report. Ocul Surf. 2017;15(3):276-283. https://doi.org/10.1016/j.jtos.2017.05.008
Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S, Knop E, Markoulli M, Ogawa Y, Perez V, Uchino Y, Yokoi N, Zoukhri D, Sullivan DA. TFOS DEWS II Pathophysiology Report. Ocul Surf. 2017;15(3):438-510. https://doi.org/10.1016/j.jtos.2017.05.011
Willcox MDP, Argüeso P, Georgiev GA, Holopainen JM, Laurie GW, Millar TJ, Papas EB, Rolland JP, Schmidt TA, Stahl U, Suarez T, Subbaraman LN, Uçakhan OÖ, Jones L. TFOS DEWS II Tear Film Report. Ocul Surf. 2017;15(3):366-403. https://doi.org/10.1016/j.jtos.2017.03.006
Wolffsohn JS, Arita R, Chalmers R, Djalilian A, Dogru M, Dumbleton K, Gupta PK, Karpecki P, Lazreg S, Pult H, Sullivan BD, Tomlinson A, Tong L, Villani E, Yoon KC, Jones L, Craig JP. TFOS DEWS II Diagnostic Methodology Report. Ocul Surf. 2017;15(3):539-574. https://doi.org/10.1016/j.jtos.2017.05.001.
Bubnova IA, Surnina ZV, Averich VV, Sarkisova KG. The effects of corneal collagen cross-linking on the corneal structure in keratoconus. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2020;136(5):268-276. (In Russ.). https://doi.org/10.17116/oftalma2020136052268
Avetisov SÉ, Surnina ZV, Novikov IA, Chernenkova NA, Tyurina AA. The effect of the tear film on the results of a direct assessment of the sensitivity of the cornea. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2020;136(2):81-85. (In Russ.). https://doi.org/10.17116/oftalma202013602181
Surnina ZV. Methods and clinical significance of the condition of corneal nerve fibers. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2021;137(2):108-113. (In Russ.). https://doi.org/10.17116/oftalma2021137021108
Avetisov SÉ, Novikov IA, Pateiuk LS. Keratoconus: etiological factors and accompanying manifestations. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2014;130(4):110-116. (In Russ.).
Brzheskii VV, Somov EE. Sindrom sukhogo glaza [Dry eye syndrome]. St. Petersburg: Apollon; 1998. (In Russ.).
Brzheskii VV, Egorova GB, Egorov EA. Sindrom «sukhogo glaza» i zabolevaniya glaznoi poverkhnosti. Klinika, diagnostika, lechenie [Dry eye syndrome and ocular surface diseases. Clinic, diagnosis, treatment]. M.: GEOTAR-Media; 2016. (In Russ.).
Sindrom «krasnogo glaza»: prakticheskoe rukovodstvo dlya vrachei-oftal’mologov [Red Eye Syndrome: A Practical Guide for Ophthalmologists]. Ed. Maichuk D.Yu. M. 2010. (In Russ.).
Anisimova NS, Anisimov SI, Shilova NF, Zemskaya AYu, Gavrilova NA, Anisimova SYu. Ultraviolet crosslinking in the treatment of keratoconus in patients with thin corneas. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2020;136(2):99-106. (In Russ.). https://doi.org/10.17116/oftalma202013602199
Bikbov MM, Khalimov AR, Usubov EL. Ultraviolet Corneal Crosslinking. Annals of the Russian Academy of Medical Sciences = Vestnik RAMN. 2016; 71(3):224-232. (In Russ.). https://doi.org/10.15690/vramn562
Gamidov GA, Mushkova IA, Kostenev SV. Modifications of corneal collagen cross-linking in keratoconus treatment. Literature review. Practical Medicine = Prakticheskaya meditsina. 2018;3(114):52-56. (In Russ.).
Xiaojing H, Peiyan S, Yin J, Can Zh, Jijun S, Ting W. Affecting factors of corneal epithelial healing following de-epithelized corneal collagen cross linking in keratoconus patients. Chin J Exp Ophthalmol. 2017;35(8):732-736. https://doi.org/10.3760/cma.j.issn.2095-0160.2017.08.014
Yilmaz FO, Yildiz BK, Tunc U, Besek NK, Yildirim Y, Demirok A. Comparison of topical omega-3 fatty acids with topical sodium hyaluronate after corneal crosslinking: Short-term results. Ocul Immunol Inflamm. 2021;9:1-7. https://doi.org/10.1080/09273948.2020.1858117
Bubnova IA, Egorova GB, Averich VV, Mitichkina TS. Medical treatment for dry eye in patients with keratoconus after corneal cross-linking. Russian Journal of Clinical Ophthalmology = RMZh. Klinicheskaya oftal’mologiya. 2020;20(2):67-71. (In Russ.). https://doi.org/10.32364/2311-7729-2020-20-2-67-71
El-Sersy TH. Corneal collagen cross-linking in patients with keratoconus associated with dry eye. J Egyptian Ophthalmol Soc. 2017;110(1):8. https://doi.org/10.4103/2090-0686.206315
Recalde JI, Duran JA, Rodriguez-Agirretxe I, Soria J, Sanchez-Tena MA, Pereiro X, Suarez T, Acera A. Changes in tear biomarker levels in keratoconus after corneal collagen crosslinking. Mol Vis. 2019;25:12-21.
Uysal BS, Akcay E, Kilicarslan A, Mutlu M, Hondur G, Kosekahya P, Cagil N. Tear function and ocular surface changes following corneal collagen cross-linking treatment in keratoconus patients: 18-month results. Int Ophthalmol. 2020;40(1):169-177. https://doi.org/10.1007/s10792-019-01161-1
Chow SSW, Chan TCY, Wong IYH, Fan MCY, Lai JSM, Ng ALK. Early epithelial complications of accelerated trans-epithelial corneal crosslinking in treatment of keratoconus: a case series. Int ophthalmol. 2018;38(6):2635-2638. https://doi.org/10.1007/s10792-017-0734-9

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