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Matyushchenko A.G.

Research Institute of Eye Diseases

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Petrachkov D.V.

Research Institute of Eye Diseases

Modern understanding of structural and biochemical characteristics of the vitreous in eyes with normal and increased axial length

Authors:

Matyushchenko A.G., Budzinskaya M.V., Petrachkov D.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2021;137(4): 110‑115

DOI: 10.17116/oftalma2021137041110

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To cite this article:

Matyushchenko AG, Budzinskaya MV, Petrachkov DV. Modern understanding of structural and biochemical characteristics of the vitreous in eyes with normal and increased axial length. Russian Annals of Ophthalmology. 2021;137(4):110‑115. (In Russ.)
https://doi.org/10.17116/oftalma2021137041110

Подписка 2025 (Russian Annals of Ophthalmology)
 
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The review highlights the features of molecular, morphological and anatomical organization of the vitreous body in normal human eyes and in eyes with elongated anterior-posterior axis. The molecular structure of the vitreous consists of various types of collagen, glycosaminoglycans, glycoproteins and proteoglycans. The lowest concentration of collagen fibrils is in the central vitreous, so the structural changes of vitreous gel associated with attenuation of the vitreous body happen there much earlier and to a greater degree. Increased aggregation of collagen fibrils with age casuses an increase of liquid fractions of the vitreous with a concomitant decrease in gel volume. Similar processes occur earlier in eyes with axial myopia. Destructive processes in myopia increase progressively with axial elongation. As a result of vitreous collapse, vitreoretinal adhesion weakens and posterior vitreous detachment occurs.

Keywords:

vitreous
myopia
vitreous pathology
fibrillar collagen
posterior vitreous detachment (PVD)

Authors:

Matyushchenko A.G.

Research Institute of Eye Diseases

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Petrachkov D.V.

Research Institute of Eye Diseases

Received:

19.08.2020

Accepted:

26.09.2020

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