Long-term use of latanoprost in the treatment of glaucoma

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Glaucoma is the main cause of irreversible blindness in the world. Latanoprost — an ester prodrug of prostaglandin F2α (PGF2α) — was the first prostaglandin analogue used in the treatment of glaucoma. The present review shows that latanoprost is the most balanced prostaglandin analogue in terms of efficacy—safety. Its use improves the quality of life of glaucoma patients, provides reliable IOP reduction, has high patient compliance, and helps with the long-term preservation of visual functions. The review also reveals the possibility of long-term (more than five years) use of the drug, as well as effective combined treatment using latanoprost and beta-blockers, considers the pediatric use of latanoprost, and discusses its neuroprotective properties.

Keywords:

prostaglandin analogue F2α (PGF2α)

glaucoma

glaucoma progression

24-hour IOP control

treatment adherence

quality of life

neuroprotection

Authors:

Kurysheva N.I.

Oftal'mologicheskij tsentr Federal'nogo mediko-biologicheskogo agentstva, ul. Gamalei, 15, Moskva, Rossijskaja Federatsija, 123098

SPIN RSCI: 3531-5880
Scopus AuthorID: 6603842519
ORCID: 0000-0002-2265-6671

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