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Kasparova E.A.

Research Institute of Eye Diseases, str. Rossolimo, 11 A, Moscow, Russia,119021

Fedorov A.A.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Sobkova O.I.

Research Institute of Eye Diseases, str. Rossolimo, 11 A, Moscow, Russia,119021

Influence of frequent instillations of anti-infective solutions on eye tissues (an experimental study)

Authors:

Kasparova E.A., Fedorov A.A., Sobkova O.I.

More about the authors

Journal: Russian Annals of Ophthalmology. 2019;135(5‑2): 160‑170

DOI: 10.17116/oftalma2019135052160

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INFLUENCE OF FREQUENT INSTILLATIONS OF ANTI-INFECTIVE SOLUTIONS ON EYE TISSUES (AN EXPERIMENTAL STUDY)
INFLUENCE OF FREQUENT INSTILLATIONS OF ANTI-INFECTIVE SOLUTIONS ON EYE TISSUES (AN EXPERIMENTAL STUDY)

To cite this article:

Kasparova EA, Fedorov AA, Sobkova OI. Influence of frequent instillations of anti-infective solutions on eye tissues (an experimental study). Russian Annals of Ophthalmology. 2019;135(5‑2):160‑170. (In Russ.)
https://doi.org/10.17116/oftalma2019135052160

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
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Abstract:

Purpose — to investigate the toxic effects of frequent instillations of anti-infective solutions (antibiotic eye drops — 0.3 and 1.4% tobramycin, 0.5% levofloxacin and 0.5% moxifloxacin; antiseptic eye drops — 0.05% pyloxidine and 0.025% chlorhexidine; antifungal drug — 2 mg/ml fluconazole solution) on ocular tissues. Material and methods. The study was conducted on 21 Wistar rats (42 eyes) using method of semi-fine sections. Results. The majority of antibiotics and antifungal agents do not cause toxic reactions in rats` eyes when instilled with frequent regimen with the exception of «fortified» 1.4% tobramycin and pyloxidine solutions, which caused a decrease in corneal endothelial cells density and formation of fibrovascular tissue in the anterior chamber. Conclusion. Frequent instillations of antimicrobial drug solutions is a safe method for the treatment of purulent corneal ulcers and purulent keratitis. The exceptions were solutions of «fortified» 1.4% tobramycin and piloxidine (vitabact).

Keywords:

antibiotic
frequent instillations
forced instillations
fortified solution
histology
experiment
rats

Authors:

Kasparova E.A.

Research Institute of Eye Diseases, str. Rossolimo, 11 A, Moscow, Russia,119021

Fedorov A.A.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Sobkova O.I.

Research Institute of Eye Diseases, str. Rossolimo, 11 A, Moscow, Russia,119021

Close metadata

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