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Voronin G.V.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Budzinskaia M.V.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Strakhovskaya M.G.

Lomonosov Moscow State University, Faculty of Biology, 1-12 Leninskie Gory, Moscow, Russian Federation, 119991

Khalatyan A.S.

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021

Antibiotic resistance in patients after serial intravitreal injections (in Russian only)

Authors:

Voronin G.V., Budzinskaia M.V., Strakhovskaya M.G., Khalatyan A.S.

More about the authors

Journal: Russian Annals of Ophthalmology. 2019;135(3): 109‑112

DOI: 10.17116/oftalma2019135031109

Views: 1579

Downloaded: 35

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To cite this article:

Voronin GV, Budzinskaia MV, Strakhovskaya MG, Khalatyan AS. Antibiotic resistance in patients after serial intravitreal injections (in Russian only). Russian Annals of Ophthalmology. 2019;135(3):109‑112. (In Russ.)
https://doi.org/10.17116/oftalma2019135031109

Подписка 2025 (Russian Annals of Ophthalmology)
 
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Despite the lack of convincing data on the effectiveness of antibiotic therapy in the prevention of Post-Injection Endophthalmitis (PIE), the use of topical antibiotics for intravitreal injections is still a common practice. Frequent, monthly use of antibiotics results in changes of the composition of conjunctival flora and spontaneous mutations of bacteria, and leads to selective survival of resistant and virulent strains that can cause serious damage inside the eye.

Keywords:

antibiotics
intravitreal injections
resistant strains
resistance
endophthalmitis

Authors:

Voronin G.V.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Budzinskaia M.V.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Strakhovskaya M.G.

Lomonosov Moscow State University, Faculty of Biology, 1-12 Leninskie Gory, Moscow, Russian Federation, 119991

Khalatyan A.S.

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021

List of references:

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  2. Aiello LP, Brucker AJ, Chang S, et al. Evolving guidelines for intravitreous injections. Retina. 2004;24:3-19. https://doi.org/10.1097/00006982-200410001-00002
  3. Milder E, Vander J, Shah C, Garg S. Changes in antibiotic resistance patterns of conjunctival flora due to repeated use of topical antibiotics after intravitreal injection. Ophthalmology. 2012;119(7):1420-1424. https://doi.org/10.1016/j.ophtha.2012.01.016
  4. Brown DM, Michels M, Kaiser PK, et al. ANCHOR Study Group. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR Study. Ophthalmology. 2009;116:57-65. https://doi.org/10.1016/j.ophtha.2008.10.018
  5. Rosenfeld PJ, Brown DM, Heier JS, et al, MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1419-1431. https://doi.org/10.1056/nejmoa054481
  6. Rezaei KA, Stone TW. Global Trends in Retina Survey. Chicago, IL: American Society of Retina Specialists; 2014.
  7. Chang DF, Braga-Mele R, Mamalis N, et al, ASCRS Cataract Clinical Committee. Prophylaxis of postoperative endophthalmitis after cataract surgery: results of the 2007 ASCRS member survey. J Cataract Refract Surg. 2007;33:1801-1805. https://doi.org/10.1016/j.jcrs.2007.07.009
  8. Moshirfar M, Feiz V, Vitale AT, et al. Endophthalmitis after uncomplicated cataract surgery with the use of fourth-generation fluoroquinolones: a retrospective observational case series. Ophthalmology. 2007;114:686-691. https://doi.org/10.1016/j.ophtha.2006.08.038
  9. Deramo VA, Lai JC, Fastenberg DM, Udell IJ. Acute endophthalmitis in eyes treated prophylactically with gatifloxacin and moxifloxacin. Am J Ophthalmol. 2006;142:721-725. https://doi.org/10.1016/j.ajo.2006.05.044
  10. Yin VT, Weisbrod DJ, Eng KT, Schwartz C, Kohly R, Mandelcorn E, et al. Antibiotic resistance of ocular surface flora with repeated use of a topical antibiotic after intravitreal injection. JAMA Ophthalmol. 2013;131:456-461. https://doi.org/10.1001/jamaophthalmol.2013.2379
  11. Mino De Kaspar H, Hoepfner AS, Engelbert M, Thiel M, Ta CN, Mette M, et al. Antibiotic resistance pattern and visual outcome in experimentally-induced Staphylococcus epidermidis endophthalmitis in a rabbit model. Ophthalmology. 2001;108:470-478. https://doi.org/10.1016/s0161-6420(00)00545-5
  12. Benoist d’Azy C, Pereira B, Naughton G, Chiambaretta F, Dutheil F. Antibioprophylaxis in prevention of endophthalmitis in intravitreal injection: a systematic review and meta-analysis. PLoS ONE. 2016;11:e0156431. https://doi.org/10.1371/journal.pone.0156431
  13. Storey P, Dollin M, Rayess N et al. The effect of prophylactic topical antibiotics on bacterial resistance patterns in endophthalmitis following intravitreal injection. Graefes Arch Clin Exp Ophthalmol. 2016;254:235-242. https://doi.org/10.1007/s00417-015-3035-x
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  17. Ageeva EV, Grodnenskaya AE, Popova KA. The role of preventive topical antibiotic treatment prior to intravitreal injection. Oftalmologicheskie vedomosti. 2015;8(2):79-83. (In Russ.) https://doi.org/10.17816/ov2015279-83
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