Level of tear endothelin-1 and plasminogen in patients with glaucoma and proliferative diabetic retinopathy

Pavlenko T.A.; Chesnokova N.B.; Davydova N.G.; Okhotsimskaia T.D.; Beznos O.V.; Grigor'ev A.V.

doi:https://doi.org/

Pavlenko T.A.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Chesnokova N.B.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Davydova N.G.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava RF

Okhotsimskaia T.D.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Beznos O.V.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Grigor'ev A.V.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Level of tear endothelin-1 and plasminogen in patients with glaucoma and proliferative diabetic retinopathy

Authors:

Pavlenko T.A., Chesnokova N.B., Davydova N.G., Okhotsimskaia T.D., Beznos O.V., Grigor'ev A.V.

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Journal: Russian Annals of Ophthalmology. 2013;129(4): 20‑23

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Pavlenko TA, Chesnokova NB, Davydova NG, Okhotsimskaia TD, Beznos OV, Grigor'ev AV. Level of tear endothelin-1 and plasminogen in patients with glaucoma and proliferative diabetic retinopathy. Russian Annals of Ophthalmology. 2013;129(4):20‑23. (In Russ.)

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

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Abstract:

A considerable tear endothelin-1 increase (2-3 times) has been found in patients with primary open-angle glaucoma and proliferative diabetic retinopathy. Patients with proliferative retinopathy also showed an increase of plasminogen level in tear fluid and a tendency of a similar increase in blood serum. No correlation between endothelin-1 and plasminogen levels in these pathologies was established. Tear endothelin-1 and plasminogen measurement could be used as an informative and non-invasive method to help prognosis making, condition severity evaluation and control the effectiveness of treatment of ocular local microcirculatory disturbances.

Keywords:

endothelin

plasminogen

tear

primary open-angle glaucoma

proliferative diabetic retinopathy

Authors:

Pavlenko T.A.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Chesnokova N.B.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Davydova N.G.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava RF

Okhotsimskaia T.D.

FGBU Moskovskiĭ nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ im. Gel'mgol'tsa Minzdrava RF, Moskva

Beznos O.V.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Grigor'ev A.V.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

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References:

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