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Kozlova Ya.I.

I.I. Mechnikov North-Western State Medical University Ministry of Health of Russia, Saint Petersburg, Russia

Frolova E.V.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

Filippova L.V.

P.N. Kashkin Research Institute of Medical Micology State educational institution of higher professional education "Sankt Peterburg Medical Academy of Postgraduate Education", Federal Agency for Healthcare and Social Development

Uchevatkina A.E.

P.N. Kashkin Research Institute of Medical Micology State educational institution of higher professional education "Sankt Peterburg Medical Academy of Postgraduate Education", Federal Agency for Healthcare and Social Development

Aak O.V.

Laboratoriia immunologii i allergologii NII meditsinskoĭ mikologii im. P.N. Kashkina, SZGMU im. I.I. Mechnikova, Sankt-Peterburg

Klimko N.N.

P.N. Kashkin Research Institute of Medical Mycology, I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint-Petersburg, Russian

Allergic bronchopulmonary aspergillosis in patients with asthma: Results of a prospective study

Authors:

Kozlova Ya.I., Frolova E.V., Filippova L.V., Uchevatkina A.E., Aak O.V., Klimko N.N.

More about the authors

Journal: Therapeutic Archive. 2017;89(8): 13‑16

DOI: 10.17116/terarkh201789813-16

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Table of contents

ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS IN PATIENTS WITH ASTHMA: RESULTS OF A PROSPECTIVE STUDY
ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS IN PATIENTS WITH ASTHMA: RESULTS OF A PROSPECTIVE STUDY

To cite this article:

Kozlova YaI, Frolova EV, Filippova LV, Uchevatkina AE, Aak OV, Klimko NN. Allergic bronchopulmonary aspergillosis in patients with asthma: Results of a prospective study. Therapeutic Archive. 2017;89(8):13‑16. (In Russ.)
https://doi.org/10.17116/terarkh201789813-16

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Abstract:

Aim. To estimate the frequency of fungal sensitization and the incidence of allergic bronchopulmonary aspergillosis (ABPA) in asthmatic patients. Subjects and methods. A total of 140 asthmatic patients were examined. They underwent allergologic (skin tests for fungal allergens, estimation of total and fungal allergen-specific IgE levels) and mycological (microscopy and inoculation of respiratory biosubstrates) examinations. Chest computed tomography, when indicated, was done. A group of patients with ABPA and that of patients with severe asthma and fungal sensitization were identified. Results. The frequency of fungal sensitization in asthmatic patients was 36%; the main allergenic fungi were Aspergillus and Alternaria. The incidence of ABPA was as high as 4% in the patients with asthma and 11% in those with severe asthma and fungal sensitization. Conclusion. The given current diagnostic criteria will assist practitioners to identify ABPA, to prevent its progression, and to initiate specific anti-inflammatory and antifungal therapy in due time.

Keywords:

allergic bronchopulmonary aspergillosis (ABPA)
asthma
fungal allergy
Aspergillus spp

Authors:

Kozlova Ya.I.

I.I. Mechnikov North-Western State Medical University Ministry of Health of Russia, Saint Petersburg, Russia

Frolova E.V.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

Filippova L.V.

P.N. Kashkin Research Institute of Medical Micology State educational institution of higher professional education "Sankt Peterburg Medical Academy of Postgraduate Education", Federal Agency for Healthcare and Social Development

Uchevatkina A.E.

P.N. Kashkin Research Institute of Medical Micology State educational institution of higher professional education "Sankt Peterburg Medical Academy of Postgraduate Education", Federal Agency for Healthcare and Social Development

Aak O.V.

Laboratoriia immunologii i allergologii NII meditsinskoĭ mikologii im. P.N. Kashkina, SZGMU im. I.I. Mechnikova, Sankt-Peterburg

Klimko N.N.

P.N. Kashkin Research Institute of Medical Mycology, I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint-Petersburg, Russian

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References:

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