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Ignatova G.L.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Antonov V.N.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Impact of vaccination on the course of bronchial and systemic inflammation in patients with COPD and CHD

Authors:

Ignatova G.L., Antonov V.N.

More about the authors

Journal: Therapeutic Archive. 2017;89(3): 29‑33

DOI: 10.17116/terarkh201789329-33

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Table of contents

IMPACT OF VACCINATION ON THE COURSE OF BRONCHIAL AND SYSTEMIC INFLAMMATION IN PATIENTS WITH COPD AND CHD
IMPACT OF VACCINATION ON THE COURSE OF BRONCHIAL AND SYSTEMIC INFLAMMATION IN PATIENTS WITH COPD AND CHD

To cite this article:

Ignatova GL, Antonov VN. Impact of vaccination on the course of bronchial and systemic inflammation in patients with COPD and CHD. Therapeutic Archive. 2017;89(3):29‑33. (In Russ.)
https://doi.org/10.17116/terarkh201789329-33

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Abstract:

Aim. To investigate the effect of 13-valent pneumococcal conjugate vaccine (PCV-13) on the clinical and functional manifestations of systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD). Subjects and methods. The protocol included 36 patients with COPD and 36 patients with COPD concurrent with CHD. The number of COPD exacerbations, hospital admissions, pneumonia cases, degree of dyspnea, and functional indicators were analyzed. The levels of markers for inflammation, such as C-reactive protein (CRP), fibrinogen, and procalcitonin (PCT), were investigated. Results. A year after vaccination, the COPD group showed decreases in the level of CRP, fibrinogen, and PCT by 11, 6, and 2%, respectively; the COPD + CHD group did by 12, 24, and 19%. PCT levels demonstrated the closest correlation with clinical and functional parameters; the other indicators showed moderate (CRP) and low (fibrinogen) correlations. Conclusion. PCV-13 vaccination can reduce systemic inflammation just a year later.

Keywords:

COPD
CHD
vaccination
markers of systemic inflammation

Authors:

Ignatova G.L.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

Antonov V.N.

South Ural State Medical University, Ministry of Health of Russia, Chelyabinsk, Russia

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References:

  1. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (GOLD): Updated 2016. 80 p.
  2. ACC/AHA/ACP-ASIM Guidelines for the Management of Patients With Chronic Stable Angina. A Report of American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina). J Am Coll Cardiol. 1999;33(7):2092-2197.
  3. Chuchalin AG, Aysanov ZR, Avdeev SN, Leshchenko IV, Ovcharenko SI, Shmelev EI Federal guidelines for the diagnosis and treatment of chronic obstructive pulmonary disease. RMJ. 2014;5:331. (In Russ.)
  4. Boev S, Dotsenko N, Shekhunova IA, Dedov VO. The combination of chronic obstructive pulmonary disease and coronary heart disease. Questions of rational therapy. http://therapia.ua/therapia/2015-/2-95 (In Russ.)
  5. Kutsenko MA, Chuchalin AG. The paradigm of comorbidity: syntropy COPD and CHD. RMJ. 2014;5:389. (In Russ.)
  6. Vertkin AL Skotnikov AS, Tikhon EY, Oralbekova JM, Gubzhokova OM. Comorbidity in COPD: role of chronic systemic inflammation. RMJ. 2014;11:811. (In Russ.)
  7. Chuchalin AG. Chronic obstructive pulmonary disease and related disorders. Part I. COPD and defeat of the cardiovascular system. Russian Medical Journal. 2008;2:58. (In Russ.)
  8. Correia LL Lebedev TY, Efremova OA. The problem of polymorbidity in cases of chronic obstroctive poimonary disease associated with some cardiovascoiar diseases. Scientific statements Belgorod State University. 2013;4(147):12-17. (In Russ.)
  9. Sin DD, Man SF. Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality. Proc Am Thorac Soc. 2005;2(1):8-11.
  10. Sin DD, Wu L, Man SF. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. Chest. 2005;127:1952-1959.
  11. Avdeev SN. Exacerbation of COPD: The value of an infectious factor and antibiotic therapy. BC. 2003;22:1205. (In Russ.)
  12. John JR. Hurst role of bronchial and systemic inflammation in the pathogenesis of chronic obstructive pulmonary disease. https://medi.ru/info/3914/ (In Russ.)
  13. Guidelines on the management of stable angina pectoris: executive summary. The task force of the management of stable angina pectoris of the European Society of Cardiology. Eur Heart J. 2006;27:1334-1381.
  14. Diagnosis and treatment of stable angina. Cardiovascular therapy and prevention. 2008;7(6):Annex 4. http://www.scardio.ru/rekomendacii/rekomendacii_rko/nacionalnye_rekomendacii_po_diagnostike_i_lecheniyu_stabilnoy_stenokardii/ (In Russ.)
  15. Rebrova OJ. Statistical analysis of medical data. The application package STATISTICA applications. M.: Mediasphere: 2006. 312 p. (In Russ.)
  16. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax. 2004;59:574-580.
  17. Ignatova GL, Antonov VN, Rodionova OV. Violations of respiratory function in the combined chronic obstructive pulmonary disease and coronary heart disease. Consilium medicum. 2014;16(11):28-32. (In Russ.)
  18. Mamaeva MG, Demko IV, Verigo Frenkel, Kraposhina AY, Solovieva IA. Markers of systemic inflammation and endothelial dysfunction in patients with chronic obstructive pulmonary disease. Siberian medical review. 2014;1(85). Reference date: 13.01.2017. URL: http://cyberleninka.ru/article/n/markery-sistemnogo-vospaleniya-i-endotelialnoy-disfunktsii-u-bolnyh-hronicheskoy-obstruktivnoy-boleznyu-legkih (In Russ.) doi:10.20333/25000136-2014-1-12-19
  19. Zubarev A. Procalcitonin — new marker for the diagnosis of severe infection (Review). Reference date: 13.01.2017. URL: http://criticare.chat.ru/004.html
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