Association of the -844G&amp;gt;A polymorphism in the catalase gene with the increased risk of essential hypertension in smokers

Bushueva O.Iu.; Ivanov V.P.; Ryzhaeva V.N.; Ponomarenko I.V.; Churnosov M.I.; Polonikov A.V.

doi:https://doi.org/10.17116/terarkh201688950-54

O.Iu. Bushueva

Kafedra biologii, meditsinskoĭ genetiki i kologii Kurskogo gosudarstvennogo meditsinskogo universiteta, Kursk

V.P. Ivanov

Polenov Russian Research Neurosurgical Institute, St. Petersburg, Russia

V.N. Ryzhaeva

Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia

I.V. Ponomarenko

KGBUZ «Altai Regional Cardiological Dispensary», Barnaul, Russia

M.I. Churnosov

Kafedra mediko-biologicheskikh distsiplin Belgorodskogo gosudarstvennogo natsional'nogo issledovatel'skogo universiteta

A.V. Polonikov

Kafedra biologii, meditsinskoĭ genetiki i kologii Kurskogo gosudarstvennogo meditsinskogo universiteta, Kursk

Association of the -844G>A polymorphism in the catalase gene with the increased risk of essential hypertension in smokers

Authors:

O.Iu. Bushueva, V.P. Ivanov, V.N. Ryzhaeva, I.V. Ponomarenko, M.I. Churnosov, A.V. Polonikov

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Journal: Therapeutic Archive. 2016;88(9): 50‑54

DOI: 10.17116/terarkh201688950-54

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Bushueva OIu, Ivanov VP, Ryzhaeva VN, Ponomarenko IV, Churnosov MI, Polonikov AV. Association of the -844G>A polymorphism in the catalase gene with the increased risk of essential hypertension in smokers. Therapeutic Archive. 2016;88(9):50‑54. (In Russ.)
https://doi.org/10.17116/terarkh201688950-54

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Abstract:

Aim. To investigate whether the functionally relevant -844G>A promotor polymorphism in the catalase (CAT) gene is associated with the development of essential hypertension (EH). Subjects and methods. The investigation enrolled 2,339 unrelated ethnic Russian people, including 1,269 EH patients and 770 apparently healthy individuals. Genotyping of CAT -844G>A (rs769214) polymorphism was performed using a TaqMan real-time polymerase chain reaction assay. Results. The -844A allele (odds ratio (OR)=1.31; 95% confidence interval (CI), 1.04 to 1.64; р=0.02) and the -844AA genotype (OR=1.41; 95% CI, 1.02 to 1.94; р=0.03) were found to be related to a higher risk of EH in the smokers. No association was found between this polymorphism and EH risk in the non-smokers. Conclusion. Smoking is a predisposing factor for development of EH in CAT -844AA genotype carriers.

Keywords:

essential hypertension

oxidative stress

catalase

genetic polymorphism

gene-environment interactions

Authors:

O.Iu. Bushueva

Kafedra biologii, meditsinskoĭ genetiki i kologii Kurskogo gosudarstvennogo meditsinskogo universiteta, Kursk

V.P. Ivanov

Polenov Russian Research Neurosurgical Institute, St. Petersburg, Russia

V.N. Ryzhaeva

Kursk State Medical University, Ministry of Health of Russia, Kursk, Russia

I.V. Ponomarenko

KGBUZ «Altai Regional Cardiological Dispensary», Barnaul, Russia

M.I. Churnosov

Kafedra mediko-biologicheskikh distsiplin Belgorodskogo gosudarstvennogo natsional'nogo issledovatel'skogo universiteta

A.V. Polonikov

Kafedra biologii, meditsinskoĭ genetiki i kologii Kurskogo gosudarstvennogo meditsinskogo universiteta, Kursk

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