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Yablonskii P.K.

Federal State Budgetary Institution of Higher Education «Saint Petersburg State University», Russia Government, 199034, St. Petersburg, Russia

Vinogradova T.I.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Levashev Yu.N.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Pavlova M.V.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Zilber E.K.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Starshinova A.A.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Sapozhnikova N.V.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Chernokhaeva I.V.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Archakova L.I.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia;
Saint Petersburg State University, Saint Petersburg, Russia

Zabolotnykh N.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Vitovskaia M.L.

Laboratoriia éksperimental'nogo tuberkuleza i novykh meditsinskikh tekhnologiĭ FGBU "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii" Minzdravsotsrazvitiia Rossii

Preclinical and clinical trials of the new tuberculosis drug perchlozon

Authors:

Yablonskii P.K., Vinogradova T.I., Levashev Yu.N., Pavlova M.V., Zilber E.K., Starshinova A.A., Sapozhnikova N.V., Chernokhaeva I.V., Archakova L.I., Zabolotnykh N.V., Vitovskaia M.L.

More about the authors

Journal: Therapeutic Archive. 2016;88(3): 111‑115

DOI: 10.17116/terarkh2016883111-115

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Table of contents

PRECLINICAL AND CLINICAL TRIALS OF THE NEW TUBERCULOSIS DRUG PERCHLOZON
PRECLINICAL AND CLINICAL TRIALS OF THE NEW TUBERCULOSIS DRUG PERCHLOZON

To cite this article:

Yablonskii PK, Vinogradova TI, Levashev YuN, et al. . Preclinical and clinical trials of the new tuberculosis drug perchlozon. Therapeutic Archive. 2016;88(3):111‑115. (In Russ.)
https://doi.org/10.17116/terarkh2016883111-115

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The paper sets forth the stages of design and introduction of the new Russian tuberculosis (TB) drug perchlozon registered in the Russian Federation in 2012. Based on the results of Phases I-III clinical trials, the authors evaluate the efficacy and safety of the agent and consider the adverse effects of its treatment for respiratory TB. The use of perchlozon as a component of combination therapy versus standard chemotherapy regimens significantly reduces abacillation time in pulmonary TB caused by its drug-resistant pathogen. In terms of the higher prevalence of TB induced by its pathogen resistant to many drugs (with multiple and broad-spectrum drug resistance), perchlozon is an essential drug that has antituberculous activity mainly against multidrug-resistant Mycobacterium tuberculosis strains and gives patients with the severest and epidemiologically poor form of TB the chance to recover.

Keywords:

tuberculosis
chemotherapy
perchlozon
preclinical evaluation
clinical efficacy
adverse events
indications for use

Authors:

Yablonskii P.K.

Federal State Budgetary Institution of Higher Education «Saint Petersburg State University», Russia Government, 199034, St. Petersburg, Russia

Vinogradova T.I.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Levashev Yu.N.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Pavlova M.V.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Zilber E.K.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Starshinova A.A.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Sapozhnikova N.V.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Chernokhaeva I.V.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia

Archakova L.I.

Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of Russia, Saint Petersburg, Russia;
Saint Petersburg State University, Saint Petersburg, Russia

Zabolotnykh N.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Vitovskaia M.L.

Laboratoriia éksperimental'nogo tuberkuleza i novykh meditsinskikh tekhnologiĭ FGBU "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii" Minzdravsotsrazvitiia Rossii

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