Age-related characteristics of the efficacy of different glucocorticosteroids in the therapy of acute lymphoblastic leukemia

Karachunsky A.I.; Rumyantseva Yu.V.; Lagoiko S.N.; Bührer C.; Tallen G.; Aleinikova O.V.; Bydanov O.I.; Korepanova N.V.; Baidun L.V.; Nasedkina T.V.; Stackelberg A.Von; Novichkova G.A.; Maschan A.A.; Litvinov D.V.; Ponomareva N.I.; Kondratchik K.L.; Mansurova E.G.; Fechina L.G.; Streneva O.V.; Yudina N.B.; Sharapova G.R.; Shamardina A.V.; Gerbek I.E.; Shapochnik A.P.; Rumyantsev A.G.; Henze G.

doi:https://doi.org/10.17116/terarkh201587741-50

Karachunsky A.I.

D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Rumyantseva Yu.V.

Lagoiko S.N.

D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia

Bührer C.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany

Tallen G.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany

Aleinikova O.V.

Republican Research and Practical Center for Pediatric Oncology and Hematology, Minsk, Belarus

Bydanov O.I.

D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia;
Republican Research and Practical Center for Pediatric Oncology and Hematology, Minsk, Belarus

Korepanova N.V.

D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia

Baidun L.V.

Russian Children’s Clinical Hospital, Ministry of Health of Russia, Moscow, Russia

Nasedkina T.V.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

Stackelberg A.Von

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany

Novichkova G.A.

Maschan A.A.

Litvinov D.V.

Ponomareva N.I.

Russian Children’s Clinical Hospital, Ministry of Health of Russia, Moscow, Russia

Kondratchik K.L.

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia;
Morozov City Children’s Clinical Hospital, Moscow Healthcare Department, Moscow, Russia

Mansurova E.G.

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Fechina L.G.

Regional Children’s Clinical Hospital One, Yekaterinburg, Russia

Streneva O.V.

Regional Children’s Clinical Hospital One, Yekaterinburg, Russia

Yudina N.B.

Voronezh Regional Children’s Clinical Hospital One, Voronezh, Russia

Sharapova G.R.

Nizhnevartovsk District Children’s Clinical Hospital, Nizhnevartovsk, Khanty-Mansi Autonomic District-Yugra, Russia

Shamardina A.V.

Nizhny Novgorod Regional Children’s Clinical Hospital, Nizhny Novgorod, Russia

Gerbek I.E.

Tomsk Regional Clinical Hospital, Tomsk, Russia

Shapochnik A.P.

Orenburg Regional Clinical Oncology Dispensary, Orenburg, Russia

Rumyantsev A.G.

Dmitry Rogachev National Medical Research Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation, Moscow, Russia

Henze G.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany

Age-related characteristics of the efficacy of different glucocorticosteroids in the therapy of acute lymphoblastic leukemia

Authors:

Karachunsky A.I., Rumyantseva Yu.V., Lagoiko S.N., Bührer C., Tallen G., Aleinikova O.V., Bydanov O.I., Korepanova N.V., Baidun L.V., Nasedkina T.V., Stackelberg A.Von, Novichkova G.A., Maschan A.A., Litvinov D.V., Ponomareva N.I., Kondratchik K.L., Mansurova E.G., Fechina L.G., Streneva O.V., Yudina N.B., Sharapova G.R., Shamardina A.V., Gerbek I.E., Shapochnik A.P., Rumyantsev A.G., Henze G.

More about the authors

Journal: Therapeutic Archive. 2015;87(7): 41‑50

DOI: 10.17116/terarkh201587741-50

Read: 3231 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Karachunsky AI, Rumyantseva YuV, Lagoiko SN, et al. . Age-related characteristics of the efficacy of different glucocorticosteroids in the therapy of acute lymphoblastic leukemia. Therapeutic Archive. 2015;87(7):41‑50. (In Russ.)
https://doi.org/10.17116/terarkh201587741-50

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Treatment of children with blunt spleen injury throughout 25-year period in Sevastopol and the Republic of Crimea. Pirogov Russian Journal of Surgery. 2025;(2):67-76

Autoimmune diseases of central nervous system and respiratory viral infections in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):39-46

The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):47-52

The association of NOS1AP gene polymorphisms with the duration of the QT interval in patients with schizophrenia receiving antipsychotic therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):98-104

Effect of narcotic analgesics on postoperative vegetative tone in children. Russian Journal of Pain. 2025;(1):34-37

Constitutional features of structures of skull base in children aged 8—12 years old in normality and with recurrent subluxation of C1—C2 vertebrae. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;(1):29-35

Speech intelligibility in a free sound field in normally hearing children aged 5—17 years. Russian Bulletin of Otorhinolaryngology. 2025;(1):5-9

On the issue of classification of vomer deformities in children. Russian Bulletin of Otorhinolaryngology. 2025;(1):35-42

Surgical treatment of pulmonary tuberculosis in children and adolescents. Pirogov Russian Journal of Surgery. 2025;(3):16-23

Hand burns in pediatrics. Pirogov Russian Journal of Surgery. 2025;(3):96-106

Abstract:

Aim. To determine predictors for decision-making on a differential approach to choosing glucocorticosteroids (GCS) for children and adolescents with acute lymphoblastic leukemia (ALL). Subjects and methods. The analysis covered 1064 primary patients aged to 1 to 18 years with ALL who had been registered at the clinics of Russia and Belorussia in April 2002 to November 2006. Before induction therapy, the patients were randomized into a dexamethasone (DEXA) 6 mg/m2 group (n=539) and a methylprednisolone (MePRED) 60 mg/m2 one (n=525). Results. The entire group showed no statistically significant differences in survival rates between the patients receiving DEXA or MePRED. However, an analysis of age groups revealed the benefits of DEXA in children younger than 14 years (the event-free survival (EFS) was 76±2 and 71±2%, respectively (p=0.048); the overall survival (OS) was 81±2 and 77±2%, respectively (р=0.046); therapy-induced mortality was 6.4% (DEXA) and11.1% (MePRED) (р=0.014); the rate of isolated extramedullary relapses was 1.5% (DEXA) and 4.4% (MePRED) ( р=0.009). At the same time, EFS and OS in 14-to-18-year-old adolescents were statistically significantly higher than in those who used MePRED (EFS, 65±6 and 52±6%, respectively (р=0.087); OS, 72±6 and 61±6%, respectively; (р=0.17). Conclusion. The findings suggest that it is possible that the choice of a GCS for ALL therapy must be also based on a patient’s age. There is a need for further studies of this matter in prospective randomized multicenter trials in children and adolescents.

Keywords:

acute lymphoblastic leukemia

children

therapy

glucocorticosteroids

dexamethasone

prednisolone

induction

Authors:

Karachunsky A.I.

Rumyantseva Yu.V.

Lagoiko S.N.

D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia

Bührer C.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany

Tallen G.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany

Aleinikova O.V.

Republican Research and Practical Center for Pediatric Oncology and Hematology, Minsk, Belarus

Bydanov O.I.

Korepanova N.V.

D. Rogachev Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia

Baidun L.V.

Russian Children’s Clinical Hospital, Ministry of Health of Russia, Moscow, Russia

Nasedkina T.V.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

Stackelberg A.Von

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany

Novichkova G.A.

Maschan A.A.

Litvinov D.V.

Ponomareva N.I.

Russian Children’s Clinical Hospital, Ministry of Health of Russia, Moscow, Russia

Kondratchik K.L.

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia;
Morozov City Children’s Clinical Hospital, Moscow Healthcare Department, Moscow, Russia

Mansurova E.G.

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia

Fechina L.G.

Regional Children’s Clinical Hospital One, Yekaterinburg, Russia

Streneva O.V.

Regional Children’s Clinical Hospital One, Yekaterinburg, Russia

Yudina N.B.

Voronezh Regional Children’s Clinical Hospital One, Voronezh, Russia

Sharapova G.R.

Nizhnevartovsk District Children’s Clinical Hospital, Nizhnevartovsk, Khanty-Mansi Autonomic District-Yugra, Russia

Shamardina A.V.

Nizhny Novgorod Regional Children’s Clinical Hospital, Nizhny Novgorod, Russia

Gerbek I.E.

Tomsk Regional Clinical Hospital, Tomsk, Russia

Shapochnik A.P.

Orenburg Regional Clinical Oncology Dispensary, Orenburg, Russia

Rumyantsev A.G.

Dmitry Rogachev National Medical Research Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation, Moscow, Russia

Henze G.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany

Close metadata