The morphofunctional features of the heart associated with acute morphine poisoning during the period of chronic drug intoxication

Altaeva A.Zh.; Galitskiĭ F.A.; Zhakupova T.Z.; Aĭdarkulov A.Sh.; Selivokhina N.V.; Zhunisov S.S.

doi:https://doi.org/10.17116/sudmed201659312-15

Altaeva A.Zh.

Almatinskiĭ filial RGKP "Tsentr sudebnoĭ meditsiny" Minzdrava Respubliki Kazakhstan Kazakhskogo natsional'nogo meditsinskogo universiteta im. S.D. Asfendiiarova, Almaty

Galitskiĭ F.A.

Aktsionernoe obshchestvo "Meditsinskiĭ universitet Astana", Astana

Zhakupova T.Z.

Astana Medical University, Kazakh Ministry of Health, Astana, Republic of Kazakhstan, 010000

Aĭdarkulov A.Sh.

Almatinskiĭ filial RGKP "Tsentr sudebnoĭ meditsiny" Minzdrava Respubliki Kazakhstan Kazakhskogo natsional'nogo meditsinskogo universiteta im. S.D. Asfendiiarova, Almaty

Selivokhina N.V.

Kazakhskiĭ natsional'nyĭ meditsinskiĭ universitet im. S.D. Asfendiiarova;
Almatinskiĭ filial "Tsentr sudebnoĭ meditsiny" Minzdrava Respubliki Kazakhstan

Zhunisov S.S.

Kazakhskiĭ natsional'nyĭ meditsinskiĭ universitet im. S.D. Asfendiiarova;
Almatinskiĭ filial "Tsentr sudebnoĭ meditsiny" Minzdrava Respubliki Kazakhstan

The morphofunctional features of the heart associated with acute morphine poisoning during the period of chronic drug intoxication

Authors:

Altaeva A.Zh., Galitskiĭ F.A., Zhakupova T.Z., Aĭdarkulov A.Sh., Selivokhina N.V., Zhunisov S.S.

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Journal: Forensic Medical Expertise. 2016;59(3): 12‑15

DOI: 10.17116/sudmed201659312-15

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To cite this article:

Altaeva AZh, Galitskiĭ FA, Zhakupova TZ, Aĭdarkulov ASh, Selivokhina NV, Zhunisov SS. The morphofunctional features of the heart associated with acute morphine poisoning during the period of chronic drug intoxication. Forensic Medical Expertise. 2016;59(3):12‑15. (In Russ.)
https://doi.org/10.17116/sudmed201659312-15

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

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Abstract:

The objective of the present study was to improve forensic medical diagnostics of the cases of death associated with morphine poisoning based on the investigation into the biochemical changes in blood and pericardial fluid as well as morphological changes in the myocardial structures. The studies were carried out with the use of thin-layer chromatography, colorimetric and morphological methods including hematoxylin and eosin, Lee’s methylene blue, and van Gieson’s picrofuscin staining. These techniques were supplemented by light and polarization microscopy. The study has demonstrated the presence of morphine in 99.16% of the blood and pericardial samples obtained in the cases of poisoning. The comparison of the results of biochemical and pathomorphological studies of the myocardium made it possible to evaluate the functional and morphological conditions of the heart in the case of acute morphine poisoning during the period of chronic drug intoxication.

Keywords:

forensic medicine

autopsy

blood

pericardial fluid

myocardium

Authors:

Altaeva A.Zh.

Almatinskiĭ filial RGKP "Tsentr sudebnoĭ meditsiny" Minzdrava Respubliki Kazakhstan Kazakhskogo natsional'nogo meditsinskogo universiteta im. S.D. Asfendiiarova, Almaty

Galitskiĭ F.A.

Aktsionernoe obshchestvo "Meditsinskiĭ universitet Astana", Astana

Zhakupova T.Z.

Astana Medical University, Kazakh Ministry of Health, Astana, Republic of Kazakhstan, 010000

Aĭdarkulov A.Sh.

Almatinskiĭ filial RGKP "Tsentr sudebnoĭ meditsiny" Minzdrava Respubliki Kazakhstan Kazakhskogo natsional'nogo meditsinskogo universiteta im. S.D. Asfendiiarova, Almaty

Selivokhina N.V.

Kazakhskiĭ natsional'nyĭ meditsinskiĭ universitet im. S.D. Asfendiiarova;
Almatinskiĭ filial "Tsentr sudebnoĭ meditsiny" Minzdrava Respubliki Kazakhstan

Zhunisov S.S.

Kazakhskiĭ natsional'nyĭ meditsinskiĭ universitet im. S.D. Asfendiiarova;
Almatinskiĭ filial "Tsentr sudebnoĭ meditsiny" Minzdrava Respubliki Kazakhstan

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References:

United Nations office on drugs and crime. Vienna: United Nations—New York, 2014. World Drug Report. 2014.
Altaeva AZh, Zhunisov SS, Aidarkulov ASh, Selivokhina NV, Kidraliev RR. Forensic medical epidemiological characteristic of fatal drug intoxication in the Almaty region, Republic of Kazakhstan. Sudebno-meditsinskaya ekspertiza. 2013;6:23-24. (In Russ.).
Andrew E, Irestedt B, Hurri T, Jacobsen P, Gujonsdottir G. Mortality and morbidity of poisonings in the Nordic countries. 2002. Clinical Toxicology. 2008;46(4):310-313. doi: 10.1080/15563650701378712.
Jönsson AK, Spigset O, Tjäderborn M, Druid H, Hägg S. Fatal drug poisoning in a Swedish general population. BMC Clinical Pharmacology. 2009;9:7. doi: 10.1186/1472-6904-9-7.
Qian Liu, Lan Zhou, Na Zheng, Luo Zhuo, Yan Liu, Liang Liu. Poisoning deaths in China: Type and prevalence detected at the Tongji Forensic Medical Center in Hubei. Forensic Science International. 2009;193(1):88-94.
Emanuele Lazzaretti Cordova Campelo, Eloisa Dutra Caldas. Postmortem data related to drug and toxic substance use in the Federal District, Brazil, from 2006 to 2008. Forensic Science International. 2010;200(1):136-140.
Kovalev AV. Forensic medical service of Russia at the beginning of the 21st century: state, problems, solutions, legal regulation of activity. The 7th All-Russian Congress of Forensic Medical Experts. Moscow. 2013;1:13-56. (In Russ.).
Singh SP, Aggarwal AD, Oberoi SS., Aggarwal KK, Thind AS, Bhullar DS., Walia DS, Chahal PS. Study of poisoning trends in north India — a perspective in relation to world statistics. Journal of Forensic and Legal Medicine. 2013;20(1):14-18.
Sgarlato A, de Roux Stephen J. Prescription opioid related deaths in New York City: a 2 year retrospective analysis prior to the introduction of the New York State I-STOP law. Forensic Science, Medicine, and Pathology. 2015;11(3):388-394. doi: 10.1007/s12024-015-9699-z.
Srettabunjong S. A Fatal heroin addict with myocardial lesion. Journal of Medical Association Thai. 2009;92(2):279-283.
Pigolkin YuI, Dolzhanskii OV, Golubeva AV. Forensic medical diagnostics of chronic narcotic intoxication based on the morphological findings. Sudebno-meditsinskaya ekspertiza. 2012;1:34-37. (In Russ.).
Bogomolova IN, Bogomolov DV, Shpekht DYu, Kul'bitskii BN. The characteristic morphological changes of the internal organs in certain forms of combined poisoning. Sudebno-meditsinskaya ekspertiza. 2012;2:18-21. (In Russ.).
Maryam Akhgari, Mohammad Hadi Panahianpour, Elham Bazmi, Afshar Etemadi-Aleagha, Amirhosein Mahdavi, Saeed Hashemi Nazari. Fatal methanol poisoning: Features of liver histopathology. Toxicology and Industrial Health. 2013;29(2):136-141.
Papyshev IP, Astashkina OG, Tuchik ES, Nikolaev BS, Cherniaev AL. Biochemical diagnostics of fatal opium intoxication. Sudebno-meditsinskaya ekspertiza. 2013;2:30-32. (In Russ).
Obukhova LM, Andriianova NA. The determination of the low and medium molecular weight substances in the blood serum as the additional diagnostic criterion in the cases of lethal poisoning with narcotic drugs. Sudebno-meditsinskaya ekspertiza. 2014;6:37-39. (In Russ.).
Shigeev SV, Ivanova NA, Ivanov SV. The detection of clozapine in the tissues of an exhumed corpse. Sudebno-meditsinskaya ekspertiza. 2014;3:39-41. (In Russ).
Barsegian SS, Maksimova TV, Morozov YuE, Pleteneva TV, Salomatin EM, Tuchik ES. The problems of expert evaluation of the results of forensic chemical investigations of clozapine in the biological material. Sudebno-meditsinskaya ekspertiza. 2014;5:40-46. (In Russ.).
Gerostamoulos D, Drummer OH, Woodford NW. Deaths linked to synthetic cannabinoids. Forensic Science, Medicine, and Pathology. 2015;11:478. doi: 10.1007/s12024-015-9669-5.
Barsegian SS, Purvina EA, Salomatin EM, Sviridova TA, Fedorova TN. Determination of morphine and codeine in forensic chemical studies with the use of a single quadrupole mass-selective detector coupled to the HPLC system. Sudebno-meditsinskaya ekspertiza. 2012;6:33-37. (In Russ).
Altaeva AZh, Zhunisov SS,. Aidarkulov ASh, Selivokhina NV, Kidraliev RR, Darikulova BU, Zagumennikova AA. Changes in the biochemical, chemical and toxicological characteristics of pericardial fluid in the case of fatal drug intoxication. Sudebno-meditsinskaya ekspertiza. 2014;1:34-36. (In Russ.).
Pigolkin, YuI, Bogomolov DV. Morphological changes of internal organs in opium addiction. Arkhiv Patologii. 2002;1:3-5. (In Russ.).
Nepomnyashchikh LM. Regenerative and plastic heart failure: molecular biological mechanisms and morphological bases. Arkhiv Patologii. 2007;3:3-12. (In Russ.).
Volkov VP. Myocardial signs of cardiotoxicity. Arkhiv Patologii. 2012;2:37-39. (In Russ.).