The role of interleukins in dental caries susceptibility: a review of current evidence and future prospects

Krivulya V.O.; Filatova A.I.; Andreeva E.A.

doi:https://doi.org/10.17116/stomat202610502156

Krivulya V.O.

Ural Medical College, Chelyabinsk, Russia

ORCID: 0000-0002-1007-3778

Filatova A.I.

Ural Medical Institute, Chelyabinsk, Russia

ORCID: 0009-0001-2539-3168

Andreeva E.A.

Ural Medical College, Chelyabinsk, Russia;
Ural Medical Institute, Chelyabinsk, Russia;
Ufa State University of science and technology, Ufa, Russia

ORCID: 0000-0002-2896-4499

The role of interleukins in dental caries susceptibility: a review of current evidence and future prospects

Authors:

Krivulya V.O., Filatova A.I., Andreeva E.A.

More about the authors

Journal: Stomatology. 2026;105(2): 56‑59

DOI: 10.17116/stomat202610502156

Read: 400 times

Contact the author

Table of contents

To cite this article:

Krivulya VO, Filatova AI, Andreeva EA. The role of interleukins in dental caries susceptibility: a review of current evidence and future prospects. Stomatology. 2026;105(2):56‑59. (In Russ.)
https://doi.org/10.17116/stomat202610502156

Подписка 2026 Стоматология (Stomatology)

Использование инфографики авторами научных работ

Recommended articles:

Investigation of the effectiveness shear bond strength of composite materials to enamel and dentin of primary teeth depending on the technology of modern universal adhesives application. Russian Journal of Stomatology. 2025;(3):62-68

Molar-incisor hypomineralization and its association with dental caries among adolescents in the European North of Russia. Stomatology. 2025;(5):48-52

The comparative clinical assessment of the carious cavities restoration on the molars contact surfaces. Stomatology. 2025;(6):11-15

Unsolved dental problems in children with congenital hyperinsulin. Stomatology. 2025;(6):67-73

Clinical and dental status of patients with xerostomia. Russian Journal of Stomatology. 2026;(1-2):123-127

Serum cytokines in patients with brain tumor undergoing uncomplicated and complicated postoperative period. Russian Journal of Anesthesiology and Reanimatology. 2025;(4):21-30

Search for informative predictors of the development and progression of multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):124-130

Molecular diagnostic biomarkers of subretinal fluid in assessing the severity and prognosis of rhegmatogenous retinal detachment. Russian Annals of Ophthalmology. 2025;(6):119-126

Abstract:

A significant role in the development of dental caries is played by a genetic predisposition, especially variations in interleukin (IL) genes that regulate the immune response and tissue permeability. Analysis of literature data confirms a significant association of interleukins (IL6, IL8, IL10, IL17, IL18) and their polymorphic variants (rs1800795/IL-6, rs1800871/IL10, IL1B/rs1143643, IL1RN/rs2234663, IL4/rs8179190) with the risk of caries, periodontitis and their complications (p<0.05). This analysis allowed us to establish the contribution of interleukins to the pathogenesis of caries. However, the contribution of these genes has not been sufficiently studied, which requires further molecular genetic studies.

Keywords:

molecular genetics

caries

interleukins

SNP

Authors:

Krivulya V.O.

Ural Medical College, Chelyabinsk, Russia

ORCID: 0000-0002-1007-3778

Filatova A.I.

Ural Medical Institute, Chelyabinsk, Russia

ORCID: 0009-0001-2539-3168

Andreeva E.A.

Ural Medical College, Chelyabinsk, Russia;
Ural Medical Institute, Chelyabinsk, Russia;
Ufa State University of science and technology, Ufa, Russia

ORCID: 0000-0002-2896-4499

Received:

01.09.2025

Accepted:

03.10.2025

Close metadata

References:

Katola VM, Tarasenko SV, Komogortseva VE. Effect of oral microbiota on the development of inflammation and somatic diseases. Rossiyskii stomatologicheskii zhurnal.2018;22(3):162-165. (In Russ.). https://doi.org/10.18821/1728-2802-2018-22-3-162-165
Paqué PN, Hjerppe J, Zuercher AN, Jung RE, Joda T. Salivary biomarkers as key to monitor personalized oral healthcare and precision dentistry: A scoping review. Front Oral Health.2022;3:1003679. https://doi.org/10.3389/froh.2022.1003679
Udina IG, Gulenko OV. Molecular-genetic mechanisms of caries development. Russian Journal of Genetics. 2018;54(4):426-434. (In Russ.). https://doi.org/10.7868/S0016675818040045
Heigetyan AV, Bragin EA, Maksiukov SYu, Labushkina AV, Alutina EL, Harseeva GG. The immunologic indicators in patients with caries of contact surfaces of lateral teeth. Klinicheskaya Laboratornaya Diagnostika. 2015;60(8): 52-54. (In Russ.).
Shoaee S, Ghasemi E, Sofi-Mahmudi A, Shamsoddin E, Tovani-Palone MR, Roshani S, Heydari MH, Yoosefi M, Masinaei M, Azadnaejafabadi S, Mohammadi E, Rezaei N, Larijani B, Fakhrzadeh H, Farzadfar F. Global, regional, and national burden and quality of care index (QCI) of oral disorders: a systematic analysis of the global burden of disease study 1990—2017. BMC Oral Health. 2024;24(1):116. https://doi.org/10.1186/s12903-023-03808-z
Alarcón-Sánchez MA, Becerra-Ruiz JS, Avetisyan A, Heboyan A. Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis. BMC Oral Health. 2024;24(1):816. https://doi.org/10.1186/s12903-024-04560-8
Deng Q, Wong HM, Peng S. Alterations in salivary profile in individuals with dental caries and/or obesity: a systematic review and meta-analysis. J Dentistry. 2024;151:105451. https://doi.org/10.1016/j.jdent.2024.105451
Alarcón-Sánchez MA, Romero-Castro NS, Becerra-Ruiz JS, Romero-Servin S, Heboyan A. Increased of IL-18 levels are associated with periodontitis: a systematic review and meta-analysis. BMC Oral Health. 2024; 24(1):981. https://doi.org/10.1186/s12903-024-04747-z
Orzechowska-Wylęgała B., Wylęgała AA, Zalejska-Fiolka J, Czuba Z, Toborek M. Pro-inflammatory cytokines and antioxidative enzymes as salivary biomarkers of dentofacial infections in children. Dental Med Probl. 2024. https://doi.org/10.17219/dmp/185733
Padmanabhan V, Islam MS, Baroudi K, Chaitanya NCSK, Tawfig Hashim N, Goud M, Rahman MM, Sharma D, Haridas S, Baki MAA, Almasri RMG. Salivary IL-6 as a Biomarker for Early Childhood and Rampant Caries: Insights from a Cross-Sectional Study. Biomedicines. 2025;13(2):293. https://doi.org/10.3390/biomedicines13020293
Khalaf AM, Al-Obaidi NS, Muhabes MH. Caries experience and salivary interleukin-17 level in pre and postmenopausal women. J Port Scie Res. 2025;8(1):8-12. https://doi.org/10.36371/port.2025.1.2
Irie K, Azuma T, Tomofuji T, Yamamoto T. Exploring the role of IL-17a in oral dysbiosis-associated periodontitis and its correlation with systemic inflammatory disease. Dentistry J. 2023;11(8):194. https://doi.org/10.3390/dj11080194
Khazova EV, Boulashova OV, Valeeva EV. Study of the rs1800795 polymorphism of the IL6 gene to verify the clinical portrait of a patient with chronic heart failure: gender aspects. Consilium Medicum. 2022;10:741-746. https://doi.org/10.26442/20751753.2022.10.201757
Reis CLB, Barbosa MCF, Machado BMSM, Baratto SSP, de Lima DC, Paza AO, Filho FB, Brancher JA, Küchler EC, de Oliveira DSB. Genetic polymorphisms in interleukin-6 and interleukin-1-beta were associated with dental caries and gingivitis. Acta Odontologica Scandinavica. 2021;79(2):96-102. https://doi.org/10.1080/00016357.2020.1788722
De Sá AR, Moreira PR, Xavier GM, Sampaio I, Kalapothakis E, Dutra WO, Gomez RS. Association of CD14, IL1B, IL6, IL10 and TNFA functional gene polymorphisms with symptomatic dental abscesses. Int Endodont J. 2007;40(7):563-572. https://doi.org/10.1111/j.1365-2591.2007.01272.x
Al-Hussein IAH, Keshavarzi F, Jwad BAAAA, Naghadehi MM, Hasan KMA. Association between IL6 rs1800795, IL10 rs1800871 and 1,800,872 polymorphisms with periodontitis. Human Gene. 2024;41:201302. https://doi.org/10.1016/j.humgen.2024.201302
Hu XP, Song TZ, Zhu YY, Wu LL, Zhang X, Zhou JY, Li ZQ. Association of ENAM, TUFT1, MMP13, IL1B, IL10 and IL1RN gene polymorphism and dental caries susceptibility in Chinese children. J Int Med Res. 2019; 47(4):1696-1704. https://doi.org/10.1177/0300060519828450
Dill A, Letra A, Chaves de Souza L, Yadlapati M, Biguetti CC, Garlet GP, Vieira AR, Silva RM. Analysis of multiple cytokine polymorphisms in individuals with untreated deep carious lesions reveals IL1B (rs1143643) as a susceptibility factor for periapical lesion development. J Endodont. 2015; 41(2):197-200. https://doi.org/10.1016/j.joen.2014.10.016
Udina IG, Vasiliev YuA, Volobuyev VV, Gracheva AS, Gulenko OV. Association of VNTR Polymorphims of the Genes Antagonist of Receptor of Interleikine 1 (IL1RN) and Interleikine 4 (IL4) with Dental Caries in Children. Russian Journal of Genetics. 2021;57(10):1215-1220. (In Russ.). https://doi.org/10.31857/S0016675821100143