Serum cytokines in patients with brain tumor undergoing uncomplicated and complicated postoperative period

Lesteva N.A.; Dryagina N.V.; Kondratiev A.N.

doi:https://doi.org/10.17116/anaesthesiology202504121

Lesteva N.A.

Polenov Russian Research Neurosurgical Institute

ORCID: 0000-0002-9341-7440

Dryagina N.V.

Almazov National Medical Research Centre

ORCID: 0000-0001-8595-6666

Kondratiev A.N.

Polenov Neurosurgical Institute

SPIN RSCI: 8235-9765
ORCID: 0000-0002-7648-2208

Serum cytokines in patients with brain tumor undergoing uncomplicated and complicated postoperative period

Authors:

Lesteva N.A., Dryagina N.V., Kondratiev A.N.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2025;(4): 21‑30

DOI: 10.17116/anaesthesiology202504121

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To cite this article:

Lesteva NA, Dryagina NV, Kondratiev AN. Serum cytokines in patients with brain tumor undergoing uncomplicated and complicated postoperative period. Russian Journal of Anesthesiology and Reanimatology. 2025;(4):21‑30. (In Russ.)
https://doi.org/10.17116/anaesthesiology202504121

Использование инфографики авторами научных работ

OBJECTIVE. TO ANALYZE

Perioperative markers of systemic inflammatory response in patients with different postoperative periods after resection of subtentorial tumors.

MATERIAL AND METHODS

The study included 156 neurosurgical patients who underwent surgery for subtentorial brain tumor. They were divided into two groups with uncomplicated postoperative period and infectious complications. Laboratory tests included interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP).

RESULTS

Serum IL-6 in patients with postoperative complications was significantly higher at the stage of hemostasis compared to patients with uncomplicated postoperative period. Serum IL-10 in patients with complicated postoperative period was significantly higher on the first postoperative day.

CONCLUSION. I

Ncreased IL-6 at the stage of hemostasis and IL-10 on the first postoperative day after resection of subtentorial tumor may be prognostic factors of postoperative infection complications.

Keywords:

interleukins

systemic inflammatory response syndrome

subtentorial tumors

anesthetic support

Authors:

Lesteva N.A.

Polenov Russian Research Neurosurgical Institute

ORCID: 0000-0002-9341-7440

Dryagina N.V.

Almazov National Medical Research Centre

ORCID: 0000-0001-8595-6666

Kondratiev A.N.

Polenov Neurosurgical Institute

SPIN RSCI: 8235-9765
ORCID: 0000-0002-7648-2208

Received:

02.01.2025

Accepted:

28.01.2025

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References:

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