Morphological features of recurrent pleomorphic adenomas of the major salivary glands

Maybogin A.M.; Visaitova Z.Yu.; Chkadua T.Z.; Ivina A.A.; Babichenko I.I.

doi:https://doi.org/10.17116/stomat202610501131

Maybogin A.M.

Central Research Institute of Dentistry and Maxillofacial Surgery;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0003-1582-2106

Visaitova Z.Yu.

Central Research Institute of Dentistry and Maxillofacial Surgery

ORCID: 0000-0002-6029-4691

Chkadua T.Z.

Central Research Institute of Dentistry and Maxillofacial Surgery

SPIN RSCI: 8514-1650
Scopus AuthorID: 36130854500
ORCID: 0000-0001-8270-8843

Ivina A.A.

Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0001-8387-4413

Babichenko I.I.

Central Research Institute of Dentistry and Maxillofacial Surgery;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0001-5512-6813

Morphological features of recurrent pleomorphic adenomas of the major salivary glands

Authors:

Maybogin A.M., Visaitova Z.Yu., Chkadua T.Z., Ivina A.A., Babichenko I.I.

More about the authors

Journal: Stomatology. 2026;103(1): 31‑36

DOI: 10.17116/stomat202610501131

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To cite this article:

Maybogin AM, Visaitova ZYu, Chkadua TZ, Ivina AA, Babichenko II. Morphological features of recurrent pleomorphic adenomas of the major salivary glands. Stomatology. 2026;103(1):31‑36. (In Russ.)
https://doi.org/10.17116/stomat202610501131

Подписка 2026 Стоматология (Stomatology)

Использование инфографики авторами научных работ

OBJECTIVE

To investigate morphological features of recurrent pleomorphic adenoma on the operative material of parotid salivary glands.

MATERIALS AND METHODS

40 cases of primary pleomorphic adenomas of the parotid salivary glands and 30 cases of recurrence of this tumor were analyzed. A comparative evaluation of various structural changes in the tumor tissue on the basis of complex morphological and immunohistochemical studies was performed. Frequency analysis between groups was performed using Chi-square and Fisher’s exact test. Null hypotheses were rejected at a significance level of p≤0.05.

RESULTS

The differences in the morphological patterns of primary and recurrent pleomorphic adenomas of the major salivary glands are presented. It was established that in the group of recurrent pleomorphic adenomas, stromal histological subtype (73.3%), partial absence of the outer capsule (85%), myxomatous changes (83.3%), formation of pseudopodia (86.6%), and multifocal growth pattern (73.6%) were more frequently observed, p<0.05.

CONCLUSION

The results obtained reflect the direction of morphogenetic changes in the tissue of recurrent PA, which improves existing understanding of their biological behavior and can be used to develop new effective treatment strategies for this pathology.

Keywords:

recurrence of pleomorphic adenoma

morphology

pseudopodia

multifocal growth

immunohistochemistry

Authors:

Maybogin A.M.

Central Research Institute of Dentistry and Maxillofacial Surgery;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0003-1582-2106

Visaitova Z.Yu.

Central Research Institute of Dentistry and Maxillofacial Surgery

ORCID: 0000-0002-6029-4691

Chkadua T.Z.

Central Research Institute of Dentistry and Maxillofacial Surgery

SPIN RSCI: 8514-1650
Scopus AuthorID: 36130854500
ORCID: 0000-0001-8270-8843

Ivina A.A.

Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0001-8387-4413

Babichenko I.I.

Central Research Institute of Dentistry and Maxillofacial Surgery;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0001-5512-6813

Received:

01.07.2025

Accepted:

02.09.2025

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References:

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