The use of photodynamic therapy in patients with severe forms of leukoplakia

Rabinovich O.F.

Peoples’ Friendship University of Russia

ORCID: 0000-0002-1018-9017

Rabinovich I.M.

Peoples’ Friendship University of Russia

ORCID: 0000-0001-8539-814X

Umarova K.V.

Central Research Institute of Dentistry and Maxillofacial Surgery

Shindich O.I.

Central Research Institute of Dentistry and Maxillofacial Surgery

Kozhedub A.A.

Central Research Institute of Dentistry and Maxillofacial Surgery

The use of photodynamic therapy in patients with severe forms of leukoplakia

Authors:

Rabinovich O.F., Rabinovich I.M., Umarova K.V., Shindich O.I., Kozhedub A.A.

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Journal: Stomatology. 2022;101(5): 11‑16

DOI: 10.17116/stomat202210105111

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To cite this article:

Rabinovich OF, Rabinovich IM, Umarova KV, Shindich OI, Kozhedub AA. The use of photodynamic therapy in patients with severe forms of leukoplakia. Stomatology. 2022;101(5):11‑16. (In Russ.)
https://doi.org/10.17116/stomat202210105111

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OBJECTIVE

The aim the study is to increase the effectiveness of the treatment of severe forms of leukoplakia with the use of photodynamic therapy.

MATERIAL AND METHODS

120 patients with severe forms of leukoplakia were examined. 30 patients were diagnosed with Cr and carcinoma in situ, and therefore they were excluded from the study. In 90 patients, the diagnosis was confirmed by histological and IHC studies. Before the use of photodynamic therapy, the degree of saturation of pathological foci with a photosensitizer was determined by the method of fluorescent diagnostics using the LED device «RFS-400».

RESULTS

As a result of treatment with photodynamic therapy using a 2nd generation photosensitizer («Photoditazine» 0.5% gel penetrator), a significant improvement in the epithelization of lesion elements was observed: in 92% of patients with verrucous leukoplakia and in 83% of patients with erosive leukoplakia.

CONCLUSION

The use of photodynamic therapy for the treatment of patients with complicated forms of leukoplakia is an effective method of treatment for this pathology.

Keywords:

photodynamic therapy (PDT)

leukoplakia

histology

oral mucosa

precancerous diseases

Authors:

Rabinovich O.F.

Peoples’ Friendship University of Russia

ORCID: 0000-0002-1018-9017

Rabinovich I.M.

Peoples’ Friendship University of Russia

ORCID: 0000-0001-8539-814X

Umarova K.V.

Central Research Institute of Dentistry and Maxillofacial Surgery

Shindich O.I.

Central Research Institute of Dentistry and Maxillofacial Surgery

Kozhedub A.A.

Central Research Institute of Dentistry and Maxillofacial Surgery

Received:

30.11.2021

Accepted:

03.02.2022

List of references:

Mashkillejson AL. Predrak krasnoj kajmy gub i slizistoj obolochki rta. M.: Meditsina; 1970. (In Russ.).
Huber MA. White oral lesions, actinic cheilitis, and leukoplakia: confusions in terminology and definition: facts and controversies. Clin Dermatol. 2010; 28(3):262-268. https://doi.org/10.1016/j.clindermatol.2009.06.011.
Lima JS, Pinto Ddos SJr, Sousa SO, Correa L. Oral leukoplakia manifests differently in smokers and non-smokers. Brazilian Oral Res. 2012;26(6): 543-549. https://doi.org/10.1590_S1806-83242012005000024
Tang H, Wu Z, Zhang J, Su B. Salivary IncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Mol Med Rep. 2013;7(3):761-766. https://doi.org/10.3892/mmr.2012.1254
Cheng YS, Rees T, Wright J. A review of research on salivary bio- markers for oral cancer detection. Clin Transl Med. 2014;3(1):3. https://doi.org/10.1186/2001-1326-3-3
Rabinovich OF, Semkin VA, Babichenko II, Bezrukov AA. Leukoplakia: clinical and pathological diagnosis. Stomatologiya. 2017;96(1):72-76. (In Russ.). https://doi.org/10.17116/stomat201796172-76
Ivina AA, Babichenko II, Rabinovich OF, Togonidze AA. Ki-67 and claudin-1 expression in hyperplasia, oral squamous inthraepithelial neoplasia and oral squamous cell carcinoma. Stomatologiya. 2014;93(1):31-33. (In Russ.). https://doi.org/10.17116/stomat20189706161
Rabinovich OF, Rabinovich IM, Abramova ES. Optimization of complex treatment of patients with severe oral leukoplakia. Stomatologiya. 2015;94(6): 19-21. (In Russ.). https://doi.org/10.17116/stomat201594619-21
Lodi G, Franchini R, Warnakulasuriya S, Varoni EM, Sardella A, Kerr AR, Carrassi A, MacDonald LCI, Worthington HV. Interventions for treating oral leukoplakia to prevent oral cancer. Cochrane Database Syst Rev. 201629; 7(7):CD001829. PMID: 27471845 PMCID: PMC6457856. https://doi.org/10.1002/14651858.CD001829.pub4
Chau L, Jabara JT, Lai W, Svider PF, Warner BM, Lin Ho-Sheng, Raza SN, Fribley AM. Topical agents for oral cancer chemoprevention: A systematic review of the literature. Oral Oncol. 2017;67:153-159. https://doi.org/10.1016/j.oraloncology.2017.02.014. Epub 2017 Mar 2.
Konopka K, Goslinski T. Photodynamic therapy in dentistry. J Dent Res. 2007;86(8):694-707. https://doi.org/10.1177/154405910708600803.
Sieron A, Namyslowski G, Misiolek M, Adamek M, Kawczyk-Krupka A. Photodynamic therapy of premalignant lesions and local recurrence of laryngeal and hypopharyngeal cancers. Eur Arch Otorhinolaryngol. 200;258(7): 349-352. https://doi.org/10.1007/s004050100347.

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