Local anesthesia in children younger than 4 years in dentistry: state of the question

Gulenko O.V.; Vasil’ev Yu.L.

doi:https://doi.org/10.17116/stomat2021100041117

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Abstract:

The article is a review of modern literature and an analysis of the legal framework regarding the use of local anesthetics in children under 4 years of age. There is a discussion of the validity of the off-label principle. In the domestic and foreign literature, there are publications highlighting the use of drugs based on 4% articaine in children under 4 years old, despite age-related contraindications according to the instructions. It is necessary to pay special attention to the regulatory status of the instructions for the medical use of the medicinal product. Summarizing the presented arguments, we can talk about the available spectrum of clinical studies, meta-analyzes and RCT data on the use of articaine in dental practice in children under 4 years of age, which indicates its effectiveness and is considered a safe alternative to lidocaine for use. in children of all ages

Keywords:

pain

children

age

local anesthetics

articaine

off-label

Authors:

Gulenko O.V.

Kuban State Medical University

Vasil’ev Yu.L.

First Moscow State Medical University. I.M. Sechenov of the Ministry of Health of Russia (Sechenov University)

Scopus AuthorID: 57194755259
ORCID: 0000-0003-3541-6068

Received:

27.07.2020

Accepted:

14.08.2020

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References:

Peedikayil FC, Vijayan A. An update on local anesthesia for pediatric dental patients. Anesth Essays Res. 2013;7(1):4‐9. https://doi.org/10.4103/0259-1162.113977.
Saxena P, Gupta SK, Newaskar V, Chandra A. Advances in dental local anesthesia techniques and devices: An update. Natl J Maxillofac Surg. 2013; 4(1):19‐24. https://doi.org/10.4103/0975-5950.117873.
Trophimus, Gnanabagyan R, Vignesh Shankar. Local Anesthetics in Pediatric Dental Practice. Res J Pharmacy Technol. 2019;12:4066-4070. https://doi.org/10.5958/0974-360X.2019.00700.5.
Andropoulos DB. Effect of Anesthesia on the Developing Brain: Infant and Fetus. Fetal Diagn Ther. 2018; 43:1-11.
Kuz’mina EM, Kuz’mina IN, Vasina SA. Stomatologicheskaya zabolevaemost’ naseleniya Rossii. Sostoyanie tverdyh tkanej zubov. Rasprostranennost’ zuboche-lyustnyh anomalij. Potrebnost’ v protezirovanii. M. 2009. (In Russ.).
Retrospective Audit of Documentation of Local Anaesthesia in The Dental Record. 2016.
Snoeck M. Articaine: a review of its use for local and regional anesthesia. Local And Regional Anesthesia. 2012;5:23-33. https://doi.org/10.2147/LRA.S16682.
Adewumi A, Hall M, Guelmann M, Riley J. The Incidence of Adverse Reactions Following 4% Septocaine (Articaine) in Children. Pediatr Dent. 2008;30:424-428.
Wright GZ, Weinberger SJ, Friedman CS, Plotzke OB. Use of articaine local anesthesia in children under 4 years of age — a retrospective report. Anesth Prog. 1989;36:268-271.
Brickhouse TH, Unkel JH, Webb MB, Best AM, Hollowell RL. Articaine use in children among dental practitioners. Pediatr Dent. 2008;30:516-521.
Nkansah P. ARTICAINE 30 Years Later. Oral Health. February 4, 2016. https://www.oralhealthgroup.com/features/1003919408/
https://www.sanofimedicalinformation.com/s/?language=de&PN=Ultracain+D-S&CN=DE
Becker DE, Reed KL. Local anesthetics: review of pharmacological considerations. Anesth Prog. 2012;59(2):90‐103. https://doi.org/10.2344/0003-3006-59.2.90
Cherobin ACFP, Tavares GT. Safety of local anesthetics. An Bras Dermatol. 2020;95(1):82‐90. https://doi.org/10.1016/j.abd.2019.09.025
Rabinovich SA, Zavodilenko LA. Sistemnaya toksichnost’ mestnyh anestetikov. Stomatologiya. 2017;96(2):36-42. (In Russ.). https://doi.org/10.17116/stomat201796236-42
Tong HJ, Alzahrani FS, Sim YF, Tahmassebi JF, Duggal M. Anaesthetic efficacy of articaine versus lidocaine in children’s dentistry: a systematic review and meta-analysis. Int J Clin Pediatr Dent. 2018;28(4):347-360. https://doi:10.1111/ipd.12363
Arrow P. A comparison of articaine 4% and lignocaine 2% in block and infiltration analgesia in children. Aust Dent J. 2012;57(3):325-333. https://doi.org/10.1111/j.1834-7819.2012.01699.x
Brickhouse TH, Unkel JH, Webb MD, Best AM, Hollowell RL. Articaine use in children among dental practitioners. Pediatr Dent. 2008;30(6):516-521.
Smith T, Urquiola R, Oueis H, Stenger J. Comparison of articaine and lidocaine in the pediatric population. J Mich Dent Assoc. 2014;96(1):34-37.
Ramadurai N, Gurunathan D, Samuel AV, Subramanian E, Rodrigues SJL. Effectiveness of 2% Articaine as an anesthetic agent in children: randomized controlled trial. Clin Oral Investig. 2019;23(9):3543-3550. https://doi.org/10.1007/s00784-018-2775-5
Sixou JL, Marie-Cousin A. Intraosseous anaesthesia in children with 4% articaine and epinephrine 1:400,000 using computer-assisted systems. Eur Arch Paediatr Dent. 2015;16(6):477-481. https://doi.org/10.1007/s40368-015-0197-5
Nizharadze N, Mamaladze M, Chipashvili N, Vadachkoria D. Articaine — the best choice of local anesthetic in contemporary dentistry. Georgian Med News. 2011;190:15-23.
Leith R, Lynch K, O’Connell AC. Articaine use in children: a review. Eur Arch Paediatr Dent. 2012;13(6):293-296.
Ramadurai N, Gurunathan D, Samuel AV, Subramanian E, Rodrigues SJL. Effectiveness of 2% Articaine as an anesthetic agent in children: randomized controlled trial. Clin Oral Investig. 2019;23(9):3543-3550. https://doi.org/10.1007/s00784-018-2775-5
Malamed SF. Handbook of Local Anesthesia. 5th ed. St. Louis: Mosby; 2004. Clinical action of specific agents, techniques of maxillary anesthesia; pp. 61-71. (189-225).
Versi E. «Gold standard» is an appropriate term. BMJ. 1992;305(6846):187. https://doi.org/10.1136/bmj.305.6846.187-b
Jurgen AHR. Claassen: The gold standard: not a golden standard. In: BMJ. Bd. 330, Nr. 7500, 2005, S. 1121. https://doi.org/10.1136/bmj.330.7500.1121.
Archives of physical medicine and rehabilitation: Guide for Authors. Elsevier (February 2007). Дата обращения 19 июля 2020 г.
Ismajlova VI, Maslak EE, Fursik TI. Opyt primeneniya «Ul’trakaina» pri lechenii detej s pul’pitom molochnyh i postoyannyh zubov. Stomatologiya detskogo vozrasta i profilaktika. 2003;2(1-2):14-16. (In Russ.).
Kasatkina AL, Maslak EE, Mishareva NI, Stavskaya SV, Filimonova EV, Fomenko IV, Panchenko ML. Obosnovanie primeneniya artikainovyh anestetikov v detskoj stomatologicheskoj praktike u detej mladshe chetyrekh let. Stomatologiya. 2017;2:93-97. (In Russ.).
Wright GZ, Weinberger SJ, Friedman CS, Plotzke OB. Use of articaine local anesthesia in children under 4 years of age — a retrospective report. Anesth Prog. 1989;36(6):268-271.
Wright GZ, Weinberger SJ, Marti R, Plotzke O. The effectiveness of infiltration anesthesia in the mandibular primary molar region. Pediatr Dent. 1991;13(5):278-283.
Dudkiewicz A, Schwartz S, Lalibert JR. Effectiveness of mandibular infiltration anesthesia in children using the local anesthetic Ultracaine (articaine hydrochloride). J Canad Dent Assoc. 1987;53(1):29-31.
Brickhouse TH, Unkel JH, Webb MD, Best AM, Hollowell RL. Articaine use in children among dental practitioners. Pediatr Dent. 2008;30:516-521.
Федеральный закон от 12.04.10 №61-ФЗ «Об обращении лекарственных средств».
Allen HC, Garbe MC, Lees J, Aziz N, Chaaban H, Miller JL, Johnson P, DeLeon S. Off-label medication use in children, more common than we think: a systematic review of the literature. J Okla State Med Assoc. 2018; 111(8):776-783.
Alsaleh MS, Alhindi MM, Alasraj AF, Assiri MA, Ahmedani MS. A comparative Study on the Hemodynamic Effects of Local Anesthetics Articaine vs. Lidocaine in Healthy Patients. EC Dental Science. 2018;173:101-106.
Abu-Mostafa N, Al-Showaikhat F, Al-Shubbar F, Al-Zawad K, Al-Zawad F. Hemodynamic changes following injection of local anesthetics with different concentrations of epinephrine during simple tooth extraction: A prospective randomized clinical trial. J Clin Exp Dent. 2015;7(4):471‐476. https://doi.org/10.4317/jced.52321
Ammerman A, Smith TW, Calancie L. Practice-based evidence in public health: improving reach, relevance and results. Ann Rev Public Health. 2014; 35:47-63.
Peedikayil FC, Vijayan A. An update on local anesthesia for pediatric dental patients. Anesth Essays Res. 2013;7(1):4‐9. https://doi.org/10.4103/0259-1162.113977
Leith R, Lynch K, O’Connell AC. Articaine use in children: A review. Eur Arch Paediatr Dent. 2012;13:293-296. https://doi.org/10.1007/BF03320829
Katyal V. The efficacy and safety of articaine versus lidocaine in dental treatments: a meta-analysis. J Dent. 2010;38:307-317.
St George G, Morgan A, Meechan J, Moles DR, Needleman I, Ng YL, Petrie A. Injectable local anaesthetic agents for dental anaesthesia. Cochrane Database Syst Rev. 2018;7(7):CD006487. Published 2018 Jul 10. https://doi.org/10.1002/14651858.CD006487.pub2
Yapp KE, Hopcraft MS, Parashos P. Articaine: a review of the literature. Br Dent J. 2011;210(7):323-329.
Ob obrashchenii lekarstvennyh sredstv. Postanovlenie Pravitel’stva RF ot 12 aprelya 2010 g. №61-FZ [Elektronnyj resurs]. (In Russ.). https://https://www.book.ru/book/900087/view.html
International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). https://www.ich.org/home.html
Titova AR, Aseckaya IL, Zyryanov SK, Polivanov VA. Nereglamentirovannoe (off-label) primenenie lekarstvennyh preparatov v pediatricheskoj praktike: nere-shennye problemy. Pediatricheskaya farmakologiya. 2015;12(3):304-308. (In Russ.).
Mardganieva EA, Ryabchenko VA, Malysheva EV, Fetisova EA, Krivogubec AK, Abishev RE, Ramanatan K. Ocenka sostoyaniya problemy nereglamentirovannyh naznachenij v pediatrii: rezul’taty oprosa pediatrov i roditelej. Kachestvennaya klinicheskaya praktika. 2016;4:63-69. (In Russ.).