The purpose of the study was to reveal gender-related dimorphism of changes in adhesive properties of the vascular wall in the dynamics of surgical treatment of chronic periodontitis (CP). A total of 51 persons aged 24 to 39 years were examined, of which 20 were clinically healthy volunteers (10 men and 10 women) and 31 were patients with CP of moderate severity (14 men and 17 women). It has been shown that endothelial dysfunction is more pronounced in men than in women with CP. Surgical treatment of CP is accompanied by a reactive increase in the concentration of soluble forms of adhesive endothelial molecules in early postoperative period more pronounced in women. In the long-term period surgical treatment causes a decrease in the impairment of the endothelial adhesive properties in men to a lesser extent than in women.