The purpose of the study is comparative evaluation of modern mineralizing means and determine the effectiveness of dental caries prevention in adults. The study was conducted on 210 patients between the ages of 35 to 55 years old, divided into 6 equal groups with different means and modes of prevention (gel Tooth Mousse GC, Japan; gel Apaden-Pro Sangi, Japan; gel Fluokal Septodont, France). For dynamic monitoring and evaluating the effectiveness of prevention interventions used CPU index, OHI-S, the evaluation of cariesresistance by Nedoseko, acid biopsy of enamel. The most stable results after using gel Tooth Mousse; Apadent-Pro provides the fastest mineralization. Already after the first Apadent-Pro application was a high cariesresistance (Ca/P=1.80±0.41; p<0.01). While rubbing gel Tooth Mousse mineralization was growing gradually. In our view, it is appropriate to combine these medications: one or double rubbing gel Apadent-Pro combine with semi-annual course gel Tooth Mousse. Clinical data and laboratory studies on the effectiveness of the application of various means of preventing persons have senior age groups demonstrated that when personalized approach to the choice of the means of prevention and the multiplicity of their application It is possible to achieve increasing enamel cariesresistance and thus reduce the increase of caries in the population.