Fluorescence diagnostics and photodynamic therapy: prospects of application in gynecological and oncogynecological practice

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he review deals with the current understanding of the mechanisms of action of fluorescent diagnostics (FD) and photodynamic therapy (PDT) and the application of these methods in the treatment of cancer and precancerous diseases in gynecology. An overview of the most widely used photosensitizers in clinical oncology, as well as technical aspects of the use of laser radiation of various intensities, is presented. The results of studies on the use of PDT and PD with various photosensitizers in patients with gynecological and oncogynecological diseases are presented. Data on the effectiveness and safety of FD and PDT are presented. Organ preservation, selectivity, sparing effect and lack of need for anesthetic care indicate the relevance of these methods of treatment and prospects for intraepithelial neoplasia and precancerous diseases of the lower genital tract.

Keywords:

photodynamic therapy

PDT

photosensitizer

cervical intraepithelial neoplasia

vaginal intraepithelial neoplasia

vulvar intraepithelial neoplasia

Photogem

Photosens

Photolon

alasens

photoditazine

hexylaminolevulinate

5-aminolevulinic acid

Authors:

Zarochentseva N.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Filonenko E.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

ORCID: 0000-0001-8506-7455

Baranov I.I.

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Rovinskaya O.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Trushina O.I.

P.A. Herzen Moscow Scientific Research Institute of Oncology

Novikova E.G.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Received:

27.10.2020

Accepted:

10.11.2020

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