Cytochemical parameters of blood neutrophils in pregnant women with diffuse toxic goiter

Alieva A.Z.

Dagestan State Medical University

Esedova A.E.

Dagestan State Medical University

Zaidieva Ya.Z.

Moscow Regional Research Institute of Obstetrics and Gynecology

Idrisova M.A.

Dagestan State Medical University

Cytochemical parameters of blood neutrophils in pregnant women with diffuse toxic goiter

Authors:

Alieva A.Z., Esedova A.E., Zaidieva Ya.Z., Idrisova M.A.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2021;21(3): 20‑24

DOI: 10.17116/rosakush20212103120

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To cite this article:

Alieva AZ, Esedova AE, Zaidieva YaZ, Idrisova MA. Cytochemical parameters of blood neutrophils in pregnant women with diffuse toxic goiter. Russian Bulletin of Obstetrician-Gynecologist. 2021;21(3):20‑24. (In Russ.)
https://doi.org/10.17116/rosakush20212103120

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)

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OBJECTIVE

To study the dynamics of changes in the cytochemical parameters of blood neutrophils in women during physiological pregnancy, as well as in pregnant women with diffuse toxic goiter.

MATERIAL AND METHODS

The study included 82 pregnant women aged 20-40 years with diffuse toxic goiter. The subject of the study was to determine the level of autoantibodies to thyroperoxidase and thyroglobulin, the cytochemical parameters of blood neutrophils — myeloperoxidase activity, the level of cationic proteins, the level of glycogen and lipids.

RESULTS

The activity of myeloperoxidase in blood neutrophils in women with physiological pregnancy (comparison group) is reduced compared to that in the control group. An even greater decrease in this indicator was noted in pregnant women with diffuse toxic goiter. These pregnant women also showed a decrease in the level of glycogen and lipids in neutrophils, more pronounced in pregnant women with moderate thyrotoxicosis syndrome. In the first trimester of pregnancy the percentage of neutrophils with a moderate and high level of stained granules tended to decrease that was reflected in the average cytochemical index.

CONCLUSION

Significant shifts in components of the phagocytic defense system were found in blood neutrophils of pregnant women with thyrotoxicosis syndrome.

Keywords:

pregnancy

diffuse toxic goiter

cytochemical parameters of neutrophils

Authors:

Alieva A.Z.

Dagestan State Medical University

Esedova A.E.

Dagestan State Medical University

Zaidieva Ya.Z.

Moscow Regional Research Institute of Obstetrics and Gynecology

Idrisova M.A.

Dagestan State Medical University

Received:

22.09.2020

Accepted:

16.10.2020

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