The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Levakov S.A.

Kafedra akusherstva i ginekologii Instituta povysheniia kvalifikatsii, zhenskaia konsul'tatsiia MSCh #170 Federal'nogo mediko-biologicheskogo agentstva Rossii, Moskva

Sheshukova N.A.

Kafedra akusherstva i ginekologii fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Dabagyan L.S.

Department of Obstetrics and Gynecology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

The etiology and pathogenesis of cervical intraepithelial neoplasias: Review of foreign literature

Authors:

Levakov S.A., Sheshukova N.A., Dabagyan L.S.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2016;16(2): 42‑45

DOI: 10.17116/rosakush201616242-45

Read: 2050 times

Download PDF (RU)
Contact the author
Table of contents

THE ETIOLOGY AND PATHOGENESIS OF CERVICAL INTRAEPITHELIAL NEOPLASIAS: REVIEW OF FOREIGN LITERATURE
THE ETIOLOGY AND PATHOGENESIS OF CERVICAL INTRAEPITHELIAL NEOPLASIAS: REVIEW OF FOREIGN LITERATURE

To cite this article:

Levakov SA, Sheshukova NA, Dabagyan LS. The etiology and pathogenesis of cervical intraepithelial neoplasias: Review of foreign literature. Russian Bulletin of Obstetrician-Gynecologist. 2016;16(2):42‑45. (In Russ.)
https://doi.org/10.17116/rosakush201616242-45

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Improvement of therapy of papi­llomavirus infe­ction latent forms. Russian Journal of Clinical Dermatology and Vene­reology. 2024;(5):575-580
Impact of various reha­bilitation programs on anxiety and depression after surgery of early-stage cervical cancer. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(5):40-44
Immu­nology of the cervix in normal and pathological conditions (literature review). Russian Journal of Human Reproduction. 2024;(5):108-117
Features of the clinical course of biological subtypes of squamous cell oropharyngeal carcinoma. P.A. Herzen Journal of Onco­logy. 2025;(1):58-62
Effect of the new coro­navirus infe­ction COVID-19 on the course and prognosis of tube­rculous meni­ngoencephalitis in HIV-infected patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):33-38
On the issue of the effe­ctiveness of HPV testing and cyto­logical examination in the framework of the combined cervical cancer screening. Russian Journal of Preventive Medi­cine. 2025;(4):23-29
Comparative analysis of morphometric and histological characteristics of HPV-associated and HPV-independent vulvar squamous cell carcinoma. Russian Journal of Archive of Pathology. 2025;(3):26-32
Influence of carriage of papi­llomavirus infe­ction on the course of exte­rnal geni­tal endo­metriosis in patients with intraepithelial lesion of the cervix. Russian Journal of Human Reproduction. 2025;(3):77-83
Modern methods of treatment of latent form of HPV infe­ction: clinical obse­rvation. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(4):425-429
Anogenital warts: from the problems of epidemiological record to the proven effect of vaccine prophylaxis on popu­lation health as a marker of global success in the fight against HPV. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(4):504-510
Abstract:

Based on the data available in the literature, the authors generalize the results of current published studies on the problem of cervical intraepithelial neoplasias. They determine the leading role of human papillomavirus in the etiology and pathogenesis of pathological processes in the cervix uteri and call attention to the fact that the development of cervical intraepithelial neoplasia is favored by some non-viral cofactors: smoking, use of oral contraceptives, a birth history, genomic features of the immune status, and infection with other pathogens of genital tract diseases. Different risks and factors of cervical dysplasia and cancer are indicated. The risk of invasive cervical cancer is emphasized to be much higher among HIV-infected women. The authors declare no conflicts of interest.

Keywords:

cervical intraepithelial neoplasias
human papillomavirus
human immunodeficiency virus
cervical cancer

Authors:

Levakov S.A.

Kafedra akusherstva i ginekologii Instituta povysheniia kvalifikatsii, zhenskaia konsul'tatsiia MSCh #170 Federal'nogo mediko-biologicheskogo agentstva Rossii, Moskva

Sheshukova N.A.

Kafedra akusherstva i ginekologii fakul'teta poslevuzovskogo professional'nogo obrazovaniia vracheĭ Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Dabagyan L.S.

Department of Obstetrics and Gynecology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Close metadata

References:

  1. WHO classufication of tumours of female reproductive organs. Edited by RJ Kurman, ML Carcangiu, CS Herrington, RH Young. 2014.
  2. Manzo-Merino J, Thomas M, Fuentes-Gonzalez AM. HPV E6 oncoprotein as a potential therapeutic target in HPV related cancers. Exspert Opin Ther Targets. 2013; 17: 11: 1357—1368.
  3. Ghittoni R, Accardi R, Hasan U. The biological properties of E6 and E7 oncoproteins from human papillomaviruses. Virus Genes. 2010. 40: 1: 1—13.
  4. Cai Q, Lv L, Shao Q. Human papillomavirus early proteins and apoptosis. Arch Gynecol Obstet. 2013; 287: 3. 541—548.
  5. White EA, Howley PM. Proteomic approaches to the study of papillomavirus-host interactions. Virology. 2013; 435: 1: 57—69.
  6. Munger K, Jones DL. Human papillomavirus carcinogenesis: an identity crisis in the retinoblastoma tumor suppressor pathway. J Virol. 2015; 89: 9: 4708—4711.
  7. Tommasino M. The human papillomavirus family and its role in carcinogenesis. Semin Cancer Biol. 2014; 26: 13—21.
  8. Roman A, Munger K. The papillomavirus E7 proteins. Virology. 2013; 445: 1—2: 138—168.
  9. Ruttkay-Nedecky B, Jimenez Jimenez AM. Relevance of infection with human papillomavirus: the role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review). Int J Oncol. 2013; 43: 6: 1754—1762.
  10. Tjalma WA, Van Waes TR, Van den Eeden LE. Role of human papillomavirus in the carcinogenesis of squamous cell carcinoma and adenocarcinoma of the cervix. Best Pract Res Clin Obstet Gynaecol. 2005; 19: 469—483.
  11. Kojima S, Kawana K, Tomio K. The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN. Am J Reprod Immunol. 2013; 69: 2: 134—141.
  12. Sanad AS, Kamel HH, Hasan MM. Prevalence of cervical intraepithelial neoplasia (CIN) in patients attending Minia Maternity University Hospital. Arch Gynecol Obstet. 2014; 289: 6: 1211—1217.
  13. Sherman ME, Schiffman M, Cox JT. Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study Group. Effects of age and human papilloma viral load on colposcopy triage: data from the randomized Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS). J Natl Cancer Inst. 2002; 94: 2: 102—107.
  14. Evans MF, Adamson CS, Papillo JL. Distribution of human papillomavirus types in ThinPrep Papanicolaou tests classified according to the Bethesda 2001 terminology and correlations with patient age and biopsy outcomes. Cancer. 2006; 106: 5: 1054—1064.
  15. Lagunas-Martínez A, Madrid-Marina V, Gariglio P. Modulation of apoptosis by early human papillomavirus proteins in cervical cancer. Biochim Biophys Acta. 2010; 1805: 1: 6—16.
  16. Tonon SA, Picconi MA, Bos PD. Physical status of the E2 human papilloma virus 16 viral gene in cervical preneoplastic and neoplastic lesions. J Clin Virol. 2001; 21: 2: 129—134.
  17. Garrett LA, McCann CK. Abnormal cytology in 2012: management of atypical squamous cells, low-grade intraepithelial neoplasia, and high-grade intraepithelial neoplasia. Clin Obstet Gynecol. 2013; 56: 1: 25—34.
  18. Crosbie EJ, Kitchener HC. Human papillomavirus as a target for management, prevention and therapy. Int J Hyperthermia. 2012; 28: 6: 478—488.
  19. Dugué PA, Rebolj M, Garred P. Immunosuppression and risk of cervical cancer. Expert Rev Anticancer Ther. 2013; 13: 1: 29—42.
  20. Gadducci A, Barsotti C, Cosio S. Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature. Gynecol Endocrinol. 2011; 27: 8: 597—604.
  21. Roura E, Castellsagué X, Pawlita M. Smoking as a major risk factor for cervical cancer and pre-cancer: results from the EPIC cohort. Int J Cancer. 2014; 135: 2: 453—466.
  22. Matsumoto K, Oki A, Furuta R. Tobacco smoking and regression of lowgrade cervical abnormalities. Cancer Sci. 2010; 101: 2065—2073.
  23. Marks M, Gravitt P, Gupta S. The association of hormonal contraceptive use and HPV prevalence. Int J Cancer. 2011; 51: 341—352.
  24. Vessey M, Yeates D, Flynn S. Factors affecting mortality in a large cohort study with special reference to oral contraceptive use. Contraception. 2010; 82: 221—229.
  25. Gavric-Lovrec V, Takac I. Use of various contraceptives and human papillomavirus 16 and 18 infections in women with cervical intraepithelial neoplasia. Int J STD AIDS. 2010; 21: 424—427.
  26. Cibula D, Gompel A, Mueck AO. Hormonal contraception and risk of cancer. Hum Reprod Update. 2010; 16: 631—650.
  27. Li C, Wu M, Wang J. A population-based study on the risks of cervical lesion and human papillomavirus Infection among women in Beijing, People’s Republic of China. Cancer Epidemiol Biomarkers Prev. 2010; 19: 2655—2564.
  28. Govindappagari S, Schiavone MB, Wright JD. Cervical neoplasia. Clin Obstet Gynecol. 2011; 54: 4: 528—536.
  29. Cao S, Gan Y, Dong X. Herpes simplex virus type 2 and the risk of cervical cancer: a metaanalysis of observational studies. Arch Gynecol Obstet. 2014; 290: 6: 1059—1066.
  30. Tomkins A, White C, Higgins SP. Primary herpes simplex virus infection mimicking cervical cancer. BMJ Case Rep. 2015; 2: 20—35.
  31. Zhao Y, Cao X, Zheng Y. Relationship between cervical disease and infection with human papillomavirus types 16 and 18, and herpes simplex virus 1 and 2. J Med Virol. 2012; 84: 12: 1920—1927.
  32. Thorsteinsson K, Ladelund S, Jensen-Fangel S. Incidence of cervical dysplasia and cervical cancer in women living with HIV in Denmark: comparison with the general population. HIV Med. 2015; 8: 223—245.
  33. Beyrer C, Sullivan P, Sanchez J. The increase in global HIV epidemics in MSM. AIDS. 2013; 27: 17: 2665—2678.
  34. Cosgrove C, Ussher JE, Rauch A. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood. 2013; 121: 951—961.
  35. Chatterjee A, Rathore A, Vidyan S. Chemokines and chemokine receptors in susceptibility to HIV-1 infection and progression to AIDS. Dis Markers. 2012; 32: 143—151.
  36. Yamada R, Sasagawa T, Kirumbi LW. Human papillomavirus infection and cervical abnormalities in Nairobi, Kenya, an area with a high prevalence of human immunodeficiency virus infection. J Med Virol. 2008; 80: 847—855.
  37. Denslow SA, Rositch AF, Firnhaber C. Incidence and progression of cervical lesions in women with HIV: a systematic global review. Int J STD AIDS. 2014; 25: 3: 163—177.
  38. Pantanowitz L, Michelow P. Review of human immunodeficiency virus (HIV) and squamous lesions of the uterine cervix. Diagn Cytopathol. 2011; 39: 1: 65—72.
  39. Ahdieh-Grant L, Li R, Levine AM. Highly active antiretroviral therapy and cervical squamous intraepithelial lesions in human immunodeficiency virus-positive women. J Natl Cancer Inst. 2004; 96: 1070—1076.
  40. Clifford GM, Polesel J, Rickenbach M. Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J Natl Cancer Inst. 2005; 97: 425—432.
  41. Firnhaber C, Michelow P. Cervical cancer and the human immunodeficiency virus: a review. South African J HIV Med. 2009; 10: 23—27.
  42. Gokhale P, Mania-Pramanik J, Sonawani A. Cervical cancer in Indian women reveals contrasting association among common sub-family of HLA class I alleles. Immunogenetics. 2014; 66: 12: 683—691.
  43. Miranda LN, Reginaldo FP, Souza DM. Greater expression of the human leukocyte antigen-G (HLA-G) and interleukin-17 (IL-17) in cervical intraepithelial neoplasia: analytical cross-sectional study. Sao Paulo Med J. 2014; 28: 48—51.
  44. Hosono S, Kawase T, Matsuo K. HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women. J Epidemiol. 2010; 20: 295—301.
  45. Ting J, Rositch AF, Taylor SM. Worldwide incidence of cervical lesions: a systematic review. Epidemiol Infect. 2015; 143: 2: 225—241.
  46. Matsumoto K, Yoshikawa H. Human papillomavirus infection and the risk of cervical cancer in Japan. J Obstet Gynaecol Res. 2013; 39: 1: 7—17.
  47. Dillner J. Prevention of human papillomavirus-associated cancers. Semin Oncol. 2015; 42: 2: 272—283.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.