Biological properties of proteins of the macroglobulin family and their role in the ovarian neoplastic process

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The paper presents the results of scientific publications by both Russian and foreign scientists and those of the author's studies of the biological properties of proteins of the macroglobulin family and their role in the development of an ovarian neoplastic process. It is suggested that immunosuppression accompanying tumor growth might be caused by the switch phenomenon of the synthesis of macroglobulins from α2-macroglobulin to pregnancy-associated α2-glycoprotein (PAG). The level of the latter in the ovarian malignancy cells has been found to be considerably dominant over that in the stroma. The predominance of a tumor cell component is likely to be accompanied by the higher PAG secretion by a growing tumor, which creates favorable conditions for the progression of ovarian cancer.

Keywords:

ovarian cancer

the biological properties of α2-macroglobulin and α2-glycoprotein

carcinogenesis

Authors:

Bazhenova L.G.

Kafedra akusherstva i ginekologii

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