Genetic parallels in the multifactor models of aggressive periodontitis and osteoporosis

Zinov'eva A.I.; Atrushkevich V.G.; Poliakov A.V.; Shchagina O.A.

doi:https://doi.org/

Zinov'eva A.I.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Atrushkevich V.G.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Poliakov A.V.

Mediko-geneticheskiĭ nauchnyĭ tsentr RAMN, Moskva

Shchagina O.A.

Mediko-geneticheskiĭ nauchnyĭ tsentr RAMN

Genetic parallels in the multifactor models of aggressive periodontitis and osteoporosis

Authors:

Zinov'eva A.I., Atrushkevich V.G., Poliakov A.V., Shchagina O.A.

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Journal: Russian Journal of Stomatology. 2011;4(6): 34‑40

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To cite this article:

Zinov'eva AI, Atrushkevich VG, Poliakov AV, Shchagina OA. Genetic parallels in the multifactor models of aggressive periodontitis and osteoporosis. Russian Journal of Stomatology. 2011;4(6):34‑40. (In Russ.)

Подписка 2026 Российская стоматология (Russian Journal of Stomatology)

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Abstract:

The article presents the results of the study on the frequency of the following alleles and genotypes: с.1340С>Т of gene CALCR, с.104-441G>T of gene COLIA1 and с.48-360AAAG of gene PTHR1 in the groups of patients presenting with aggressive generalized periodontitis (AGP) or osteoporosis, healthy controls (without AGP and osteoporosis) and a random sample from the general population (RPA). The risk of development of AGP was estimated as a function of the carriership of polymorphic variants of the aforementioned genes. It was shown that the risk increases in subjects with the combination of several predisposing genotypes. The comparative analysis of susceptibility to AGP and osteoporosis in the carriers of polymorphic variants of c.1340С>Т, с.104-441G>T, с.48-360AAAG was carried out.

Keywords:

aggressive periodontitis

osteoporosis

calcium-regulating hormones

bone metabolism

bone collagen

Authors:

Zinov'eva A.I.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Atrushkevich V.G.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Poliakov A.V.

Mediko-geneticheskiĭ nauchnyĭ tsentr RAMN, Moskva

Shchagina O.A.

Mediko-geneticheskiĭ nauchnyĭ tsentr RAMN

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References:

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