Effectiveness of transcranial electrical stimulation in the treatment of olfactory dysfunction

Dobretsov K.G.; Kashirskiy D.V.; Malygin A.V.

doi:https://doi.org/10.17116/rosrino20253302190

Dobretsov K.G.

Research Institute of Olfaction and Olfactory Pathology

SPIN RSCI: 1017-7664
Scopus AuthorID: 24477018000
ORCID: 0000-0002-7468-9117

Kashirskiy D.V.

Russian State University for the Humanities;
Financial University under the Government of the Russian Federation

SPIN RSCI: 4389-5243
ORCID: 0000-0002-8251-2653

Malygin A.V.

Limited Liability Company “Center for Transcranial Electrical Stimulation”

Effectiveness of transcranial electrical stimulation in the treatment of olfactory dysfunction

Authors:

Dobretsov K.G., Kashirskiy D.V., Malygin A.V.

More about the authors

Journal: Russian Rhinology. 2025;33(2): 90‑95

DOI: 10.17116/rosrino20253302190

Read: 725 times

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To cite this article:

Dobretsov KG, Kashirskiy DV, Malygin AV. Effectiveness of transcranial electrical stimulation in the treatment of olfactory dysfunction. Russian Rhinology. 2025;33(2):90‑95. (In Russ.)
https://doi.org/10.17116/rosrino20253302190

Подписка 2026 Российская ринология (Russian Rhinology)

Использование инфографики авторами научных работ

OBJECTIVE

To study the effectiveness of TES in the area of the olfactory nerve in patients with olfactory dysfunction.

PATIENTS AND METHODS

Treatment of 41 patients with post-infectious hyposmia aged 18—71 years (30 women, 73.17%; 11 men, 26.83%) was performed. The Russian version of the Sniffin’ Sticks test (RVSS) was used to assess olfactory thresholds. TES was carried out with an average current of 2.5 mA, a session duration of 30 minutes and a treatment course of 10 days.

RESULTS

Olfactory index of patients with olfactory impairment after TES therapy of the olfactory nerve has improved by 1.5 times. TES has resulted in improvement of odor thresholds in 73% of cases. Significant improvement of olfaction and increase of RVSS indices by 50% or more have been determined in 25% of patients. Improvement of odor perception did not depend on the age and sex of patients.

CONCLUSION

TES therapy is an effective method of treating olfactory dysfunction and can be used in comprehensive therapy of olfactory disorders.

Keywords:

TES therapy

transcranial electrical stimulation

hyposmia

anosmia

olfactory dysfunction

Russian version of the Sniffin’ Sticks test

RVSS

olfactory threshold evaluation

olfaction

olfactory index

Authors:

Dobretsov K.G.

Research Institute of Olfaction and Olfactory Pathology

SPIN RSCI: 1017-7664
Scopus AuthorID: 24477018000
ORCID: 0000-0002-7468-9117

Kashirskiy D.V.

Russian State University for the Humanities;
Financial University under the Government of the Russian Federation

SPIN RSCI: 4389-5243
ORCID: 0000-0002-8251-2653

Malygin A.V.

Limited Liability Company “Center for Transcranial Electrical Stimulation”

Received:

26.12.2024

Accepted:

09.01.2024

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References:

Dobretsov KG, Kashirsky DV. Prevalence of olfactory disorders in the Russian Population based on survey results. Russian Rhinology. 2024;32(3):189-194. (In Russ.).
Hox V, Bobic S, Callebaux I, Jorissen M, Hellings PW. Nasal obstruction and smell impairment in nasal polyp disease: correlation between objective and subjective parameters. Rhinology. 2010;48:426-432.
Valsamidis K, Printza A, Titelis K, Constantinidis J, Triaridis S. Olfaction and quality of life in patients with nasal septal deviation treated with septoplasty. Am J Otolaryngol. 2019;40:747-754.
Rombaux P, Martinage S, Huart C, Collet S. Post-infectious olfactory loss: A cohort study and update. B-ENT. 2009;5(suppl 13):89-95.
Lee JC, Nallani R, Cass L, Bhalla V, Chiu AG, Villwock JA. A systematic review of the neuropathologic findings of post-viral olfactory dysfunction: Implications and novel insight for the COVID-19 pandemic. Am J Rhinol Allergy. 2021;35:323-333.
Doty RL, Yousem DM, Pham LT, Kreshak AA, Geckle R, Lee WW. Olfactory dysfunction in patients with head trauma. Arch Neurol. 1997;54:1131-1140.
Jobin B, Zahal R, Bussières EL, Frasnelli J, Boller B. olfactory identification in subjective cognitive decline: A meta-analysis. J Alzheimers Dis. 2021;79:1497-1507.
Yao L, Pinto JM, Yi X, Li L, Peng P, Wei Y. Gray matter volume reduction of olfactory cortices in patients with idiopathic olfactory loss. Chem Senses. 2014;39:755-760.
Hummel T, Rissom K, Reden J, Hahner A, Weidenbecher M, Huttenbrink KB. Effects of olfactory training in patients with olfactory loss. Laryngoscope. 2009;119:496-499.
Silas J, Atif MA, Doty RL. Transcranial magnetic stimulation: a treatment for smell and taste dysfunction. Am J Otolaryngol. 2011;32(2):177.
Henkin RI, Potolicchio SJ Jr, Levy LM. Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation. Am J Otolaryngol. 2011;32(1):38-46.
Badran BW, Gruber EM, O’Leary GH, Austelle CW, Huffman SM, Kahn AT, McTeague LM, Uhde TW, Cortese BM. Electrical stimulation of the trigeminal nerve improves olfaction in healthy individuals: A randomized, double-blind, sham-controlled trial. Brain Stimul. 2022; 15(3):761-768.
Shiozawa P, Cordeiro Q, Cho HJ, Trevizol AP, Brietzke E. A critical review of trials of transcranial direct current stimulation and trigeminal nerve stimulation for depression: the issue of treatment-emergent mania. Trends Psychiatry Psychother. 2017;39(1):48-53.
Patent for utility model No. 181726 U1 Russian Federation, IPC A61N 1/36. Apparatus for transcranial electrical stimulation of endorphin mechanisms of the brain: No. 2018102866: declared 25.01.2018: published 26.07.2018. A.V. Malygin. (In Russ.).
Lebedev VP, Malygin AV, Trusov SV. Endorphin deficiency syndrome and TES therapy. Non-drug medicine. 2012;3:117-119. (In Russ.).
Fudin NA, Khadartsev AA, Moskvin SV. Transcranial electrical stimulation and laser phoresis of serotonin in athletes with a combination of fatigue and psychoemotional stress. Problems of Balneology, Physiotherapy and Exercise Therapy. 2019;96(1):37-42. (In Russ.). https://doi.org/10.17116/kurort20199601137
Khadartsev AA, Tokarev AR, Tokareva SV, Khromushin VA. Transcranial electrical stimulation in the treatment of psychosomatic disorders in industrial workers. Problems of Balneology, Physiotherapy and Exercise Therapy. 2019;96(2):39-44. (In Russ.). https://doi.org/10.17116/kurort20199602139
Akhedzhak-Naguze SK. The effect of transcranial electrical stimulation on the frontal cortex of the human brain in increasing stress resistance. Higher school: scientific research: Proceedings of the Interuniversity Scientific Congress, Moscow, February 19, 2020. Moscow: Infinity; 2020. (In Russ.).
Sukhova AV, Preobrazhenskaya EA. Efficiency of transcranial electrical stimulation in comorbid course of occupational hearing loss and hypertension. Hygiene and Sanitation. 2022;101(12):1493-1498. (In Russ.).
Tokareva SV. Evaluation of the effectiveness of transcranial electrical stimulation in the rehabilitation of patients who have had COVID-19. Bulletin of new medical technologies [Electronic publication]. 2022;16(3):97-104. (In Russ.).
Dobretsov KG, Kashirskiy DV. Study of the olfactory threshold using the Russian version of the Sniffin Stix test. Russian Rhinology. 2024;1:6-10. (In Russ.). https://doi.org/10.17116/rosrino2024320116
Oleszkiewicz A, Schriever VA, Croy I, Hähner A, Hummel T. Updated Sniffin’ Sticks normative data based on an extended sample of 9139 subjects. Eur Arch Otorhinolaryngol. 2019;276(3):719-728.