The role of the growth factor TGF-ß1 in the pathogenesis of chronic rhinitis associated with hypothyroidism

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OBJECTIVE

To determine the content in the blood serum and nasal secretion of patients with hormonal rhinitis TGF-β1 and evaluate their levels depending on the severity of the clinical manifestations of the disease.

PATIENTS AND METHODS

The main group consisted of 60 patients with symptoms of chronic rhinitis with hypothyroidism, and the comparison group — 30 people without thyroid pathology and nasal problems. All patients with hypothyreoidism were on replacement therapy (Levothyroxin). The concentration of TGF-β1 was studied by enzyme-linked immunosorbent assay (ELISA) on a microplate photometer Multiscan EX. A questionnaire was used to assess the symptoms of rhinitis, which provided the of rhinitis were evaluated on a visual-analogue scale, nasal breathing by the method of anterior active rhinomanometry, endoscopy.

RESULTS AND CONCLUSION

It was proved that TGF-β1 of nasal secretion, the level of which correlated with the presence of nasal obstruction to a greater extent than the value of this indicator in blood serum, was used in the diagnostic complex of hormonal rhinitis associated with thyroid dysfunction. Patterns were revealed that showed that the severity of the clinical manifestations of hormonal rhinitis depends on the level of TGF-β1 in nasal secretion (p<0.05—0.001). The higher levels of TGF-β1 in nasal secretions were detected in group with hypothyroidism compared with healthy patients without thyroid pathology, which suggests the presence of persistent combined (edematous and proliferative) changes in the nasal mucosa in patients with hormonal rhinitis.

Keywords:

hypothyroidism

hormonal rhinitis

thyroid gland

Authors:

Chernykh N.M.

Irkutsk State Medical University

Received:

06.01.2022

Accepted:

04.02.2022

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