The study of hormonal rhinitis with hypothyroidism is due to the significant prevalence of iodine deficiency diseases in the world. One of the least studied aspects of this problem is the pathogenesis of rhinitis. Little information has been accumulated in the literature on the role of TGF-β1 in the development of chronic inflammation of the nasal mucosa, and with hormonal rhinitis in hypothyroidism such data are not available.
OBJECTIVE
To determine the content in the blood serum and nasal secretion of patients with hormonal rhinitis TGF-β1 and evaluate their levels depending on the severity of the clinical manifestations of the disease.
PATIENTS AND METHODS
The main group consisted of 60 patients with symptoms of chronic rhinitis with hypothyroidism, and the comparison group — 30 people without thyroid pathology and nasal problems. All patients with hypothyreoidism were on replacement therapy (Levothyroxin). The concentration of TGF-β1 was studied by enzyme-linked immunosorbent assay (ELISA) on a microplate photometer Multiscan EX. A questionnaire was used to assess the symptoms of rhinitis, which provided the of rhinitis were evaluated on a visual-analogue scale, nasal breathing by the method of anterior active rhinomanometry, endoscopy.
RESULTS AND CONCLUSION
It was proved that TGF-β1 of nasal secretion, the level of which correlated with the presence of nasal obstruction to a greater extent than the value of this indicator in blood serum, was used in the diagnostic complex of hormonal rhinitis associated with thyroid dysfunction. Patterns were revealed that showed that the severity of the clinical manifestations of hormonal rhinitis depends on the level of TGF-β1 in nasal secretion (p<0.05—0.001). The higher levels of TGF-β1 in nasal secretions were detected in group with hypothyroidism compared with healthy patients without thyroid pathology, which suggests the presence of persistent combined (edematous and proliferative) changes in the nasal mucosa in patients with hormonal rhinitis.
