Introduction. Chronic rhinosinusitis (CRS) is a multi-factorial disease, the pathogenesis of which is not fully understood. In clinical practice, chronic bacterial rhinosinusitis and chronic polypus rhinosinusitis are distinguished. Currently, glutathione-S-transferase (GST) and tissue growth factors have a special place in the pathogenesis of chronic rhinosinusitis. The aim of the study is to access the role of GST genes and growth factors in the formation of a predisposition to CRS in the population of the Kursk region. Material and methods. From 2010 to 2018, 100 patients aged 18—60 years, and 100 healthy participants (the control group) were examined at the ENT Department of the N.S. Korotkov Kursk City Hospital №1. Venous blood, measuring 6 ml, with 3-substitued potassium salts of ethylene diamine tetra acetate (pH=7.8), was drawn into evacuated plastic test tubes from all patients and participants. Genomic deoxyribonucleic acid was isolated using the method of phenol-chloroform extraction. Genotyping of deletion polymorphisms of GSTM1 and GSTT1 genes were done using the method of multiplex polymerase-chain reaction (PCR), while polymorphism of the I105V genes GSTP1, –509C/T TGF-1, and +61G/A EGF were done using the PCR method. The resulting product was examined under ultraviolet light. The c2 criterion was used to evaluate the conformity of the genotype and allele distributions, and to compare their frequencies among the 2 groups. With respect to the odds ratio (OR), we concluded that alleles and genotypes with a predisposition to CRS are associated. The result was treated as statistically significant at p<0.05. Results. Comparative analysis of the allele frequencies and genotypes of the studied polymorphisms of genes +/0 GSTM1, +0 GSTT1, I105V GSTP1, Y462V CYP1A1, +61G/A EGF and –509C/T TGF-1 did not reveal any differences between the 2 study groups. At the same time, the deletion genotype del/del of the gene GSTT1 (OR=6.26, 95% CI=1.19—4.67; p=0.01) and the alleles of the genes GSTT1 0 (OR=2.11, 95% CI=1.11—3.99; p=0.02) and +(OR=2.08, 95% CI=1.11—3.91; p=0.03) were associated with an increased risk of developing CRS. The frequency of the del/del GSTT1 genotype was higher in the group of non-smokers with CRS (12%) than in the group of healthy non-smokers (7%) (OR=2.79, 95% CI=0.99—7.81; p=0.049). No statistically significant differences in the frequencies of the polymorphic variants of the genes under study, GSTM1, GSTT1, GSTP1, CYP1A1, EGF, and EGF-1, were uncovered between the group of CRS patients and the healthy smokers.