Aim. The objective of the present study was to optimize the regimens and the methods for the diode and holmium laser irradiation of the tissues of the inferior nasal turbinated bones for the treatment of the patients presenting with vasomotor rhinitis. Materials and methods. A total of 70 patients at the age varying from 17 to 63 years were available for the clinical examination and the interviewing with the use of a questionnaire that included questions on the specific nature of the complaints of the patients, duration of the disease, the duration and the frequency of application of vasoconstrictive drops. The data thus obtained were supplemented by the results of inspection of the ENT organs and computed thermography of the nose and paranasal sinuses. The following two types of the lasers were used for the treatment of patients with vasomotor rhinitis, viz. a holmium laser (Dornier Medialis Holmium; Ho: YAG - the solid state laser with the wavelength of 2.080 mcm which generated laser radiation with a power up to 25 W at a frequency of 3-10 Hz. 2) and a diode laser (Dornier Medialis D Lite Beam; Lazermed 10-01) operated at a wavelength of 940 nm and a pulse power of 60 W. The working regimens was either continuous or pulsed. The effects of laser irradiation of the inferior nasal turbinated bones were as follows: intramucous coagulation (2 lines), surface coagulation (2 line), pointed coagulation (front and back ends, central parts of the conchae). The effect of laser radiation was assessed based on the rhinoscopic pictures and the results of the questionnaire studies carried out on the 10th day, within 1 month, 2 months, 6 months, and 1 year after the intervention. Results. The most pronounced response of the tissues of the inferior nasal turbinated bones was provoked by surface coagulation. The inflammation and oedema were less expressed in the case of the intramucous coagulation. The reactive changes associated with pointed coagualtion in the frontal and rear areas, and also in the central part of the nasal conchae were minimally expressed. The analysis of the results obtained within 2 months after the treatment based on the visual-analog scale (that allowed to evaluate the nasal breathing, dryness in the nose, nasal secretion , the presence of nasal crust, and the sense of smell) showed that the most reliable methods for the estimation of the influence of laser radiation on the tissues of the inferior nasal turbinated bones include intramucous coagulation and pointed coagulation in the three zones. In the case of external coagulation, the patient has to undergo the secondary operation (intramucous coagulation). As far as the duration of the rehabilitation period is concerned, the least reactive changes were observed following the pointed influence on the three three zones. Conclusion. The dependence of the outcomes of laser irradiation of the tissues of the inferior nasal turbinated bones used for the treatment of the patients presenting with vasomotor rhinitis and of the duration of the postoperative period on the type and mode of irradiation remains to be elucidated.