OBJECTIVE

To study the prevalence of phenotypes of chronic heart failure (CHF) with preserved ejection fraction (CHFpEF) in hospital patients, their clinical characteristics, comorbidity, treatment features.

MATERIALS AND METHODS

A retrospective analysis of 215 medical records (003/u form) of patients with CHF admitted to the emergency cardiology department of the City Clinical Hospital №11 from 01.10.2023 to 31.12.2023 was carried out. Demographic data, clinical manifestations of the disease, concomitant pathology were analyzed, phenotypes of CHFpEF were identified with the aid of cluster analysis of 15 qualitative variables, approaches to drug therapy were studied.

RESULTS

The proportion of CHFpEF amounted to 71.2%, and 3 main phenotypes of the disease were identified. Phenotype 1: «fragile» multimorbid patients with CHFpEF (30.1%), characterized by the high prevalence of atrial fibrillation, stage 3b chronic kidney disease, presence of thyroid function abnormalities, anemia. Phenotypes 2 (40.5%) and 3 (29.4%) were presented by patients with cardiometabolic disorders; obesity, dyslipidemia and diabetes mellitus have been identified in these subjects. The high prevalence of ischemic heart disease has been noted in patients of phenotype 2, paroxysmal atrial fibrillation — in patients of phenotype 3.

CONCLUSION

Patients with chronic heart failure with preserved ejection fraction are characterized by high incidence of comorbidity. The group of elderly patients with many concomitant diseases and groups of «cardiometabolic» patients with a predominance of ischemic heart disease or paroxysmal atrial fibrillation are clearly distinguished.