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Nedogoda S.V.
Volgograd State Medical University
Ledyaeva A.A.
Volgograd State Medical University
Salasyuk A.S.
Volgograd State Medical University
Chumachek E.V.
Volgograd State Medical University
Tsoma V.V.
Volgograd State Medical University
Barykina I.N.
Volgograd State Medical University
Lutova V.O.
Volgograd State Medical University
Popova E.A.
Karpovich Krasnoyarsk Interdistrict clinical hospital of emergency medical care;
Voino-Yasenetsky Krasnoyarsk state medical University
Vlasov D.S.
Volgograd State Medical University
Bychkova O.I.
Medical Department of the Federal Security Service of Russia in the Volgograd Region
Labaznikova V.V.
Volgograd State Medical University
The effect of COVID-19 on vascular elasticity and liver function in overweight patients
Journal: Russian Journal of Preventive Medicine. 2023;26(2): 69‑78
Views: 1173
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To cite this article:
Nedogoda SV, Ledyaeva AA, Salasyuk AS, et al. . The effect of COVID-19 on vascular elasticity and liver function in overweight patients. Russian Journal of Preventive Medicine.
2023;26(2):69‑78. (In Russ.)
https://doi.org/10.17116/profmed20232602169
To study the changes in the vascular wall, vascular age and metabolic parameters in polymorbid COVID-19 convalescents.
The study included 62 patients with hypertension who reached the target blood pressure (BP) with dual antihypertensive therapy after severe and extremely severe COVID-19. The following examinations were performed: laboratory tests of metabolic parameters, assessment of changes in the vessel elasticity indices (pulse-wave velocity (PWV), augmentation index (AI), central systolic BP (cSBP), 24-hour BP monitoring, and non-invasive markers of liver fibrosis.
According to office BP measurements, after the coronavirus infection, an increase in systolic BP (SBP) by 29.6% and diastolic BP (DBP) by 23.6%, as well as heart rate (HR) by 11.8% (p<0.05) was reported during regular antihypertensive therapy. In addition, 24-hour BP monitoring data indicated an increase in the average daily SBP, DBP, and heart rate. After the coronavirus infection, an increase in PWV by 35.4% (p<0.05), AI by 24.4% (p<0.05), cSBP by 22.1% were reported. Carbohydrate and lipid metabolism parameters deteriorated. A pronounced adverse effect of coronavirus infection on liver function was observed. The vascular age (according to the modified SCORE scale) increased by 6 years (p<0.05).
Our study showed that patients after severe and extremely severe COVID-19 have a high risk of liver fibrosis, hypertension and lipid metabolism control worsening and accelerating vascular aging.
Keywords:
Authors:
Nedogoda S.V.
Volgograd State Medical University
Ledyaeva A.A.
Volgograd State Medical University
Salasyuk A.S.
Volgograd State Medical University
Chumachek E.V.
Volgograd State Medical University
Tsoma V.V.
Volgograd State Medical University
Barykina I.N.
Volgograd State Medical University
Lutova V.O.
Volgograd State Medical University
Popova E.A.
Karpovich Krasnoyarsk Interdistrict clinical hospital of emergency medical care;
Voino-Yasenetsky Krasnoyarsk state medical University
Vlasov D.S.
Volgograd State Medical University
Bychkova O.I.
Medical Department of the Federal Security Service of Russia in the Volgograd Region
Labaznikova V.V.
Volgograd State Medical University
Received:
23.11.2022
Accepted:
25.11.2022
List of references:
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