Early non-invasive rapid diagnostics of the head and neck skin basal cell carcinoma for improving the quality of cancer care organization

Close metadata

Recommended articles:

The state of oncological care for the Far Eastern Federal District population. Russian Journal of Preventive Medicine. 2024;(4):18-24

Development of professional activities of healthy lifestyle specialists without medical education. Russian Journal of Preventive Medicine. 2024;(4):116-123

Determination of factors influencing the medical checkups effectiveness of adult population living in rural areas. Russian Journal of Preventive Medicine. 2024;(10):23-28

Oral cavity cancer epidemiology in men and women in the Siberian Federal District. Russian Journal of Preventive Medicine. 2024;(11):46-53

Localized scleroderma: etiology, pathogenesis, clinical manifestations, difficulties of diagnosis and therapy. Russian Journal of Clinical Dermatology and Venereology. 2024;(1):12-18

Multi-center open comparative randomized study of efficacy and safety of Akatinol Memantine 20 mg (single-doses) vs Akatinol Memantine 10 mg (double-doses) in patients with vascular dementia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(2):69-77

Long-term follow-up of adult patients with serial and status course of epileptic seizures. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):63-68

Physicians’ adherence to clinical guidelines: impact on mortality in the treatment of solid tumors (a systematic review and meta-analysis). Medical Technologies. Assessment and Choice. 2024;(2):28-39

Effectiveness of spinal traction in degenerative spine diseases. (A literature review). Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(4):60-69

Comparative analysis of laparoscopic cholecystectomy outcomes in acute calculous cholecystitis: importance of indocyanine green, optimal dosing regimen. Pirogov Russian Journal of Surgery. 2024;(11):72-76

Current Healthcare service needs to develop the methods of early detection of socially significant diseases, including to improve the quality of cancer care organization, as patients with malignant neoplasms visit a doctor lately, when the treatment may be not effective. Accordingly, attention should be paid to methods of prevention and early non-invasive diagnostics of this pathology. The use of optical technologies seems promising for this purpose. The article presents an experimental substantiation of using technology of confocal photoluminescence microspectroscopy and Raman scattering at a wavelength of 532 nm in vitro as the first stage of early non-invasive diagnostics method’s development of skin cancers, in this case — head and neck cutaneous basal cell carcinoma (BCC). The study analyzed the spectrum of intact skin tissue and BCC, which was accompanied with morphological confirmation of the diagnosis. The examination of intact skin tissue, using scanning Raman confocal Confotec MR520 («SOL Instruments», the Republic of Belarus) microscope-spectrometer, photoluminescence effects and Raman scattering. The experimental substantiation for development of optical diagnostic parameters’ set, which allows to analyze the changes occurring in different layers of human skin in normal and in case of skin BCC in real time, was carried out. The obtained results can serve as a preparatory stage to develop an early non-invasive diagnostics method of various types of skin neoplasms in short period to identify a malignant process at the initial stage and to improve cancer care.

Keywords:

cancer care

early cancer diagnostics

non-invasive diagnostics

optical technologies

Raman scattering

fluorescence

quality of medical care organization

efficacy

basal cell carcinoma of skin

head and neck cancers

Authors:

Timurzieva A.B.

N.A. Semashko National Research Institute of Public Health;
P.N. Lebedev Physical Institute

ORCID: 0000-0003-1817-3228

Rimskaya E.N.

P.N. Lebedev Physical Institute

ORCID: 0000-0001-7802-0720

Kudrin K.G.

P.N. Lebedev Physical Institute;
Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-7041-4557

Shelygina S.N.

P.N. Lebedev Physical Institute

ORCID: 0000-0002-2964-5430

Duvansky V.A.

Peoples’ Friendship University of Russia

ORCID: 0000-0001-5880-2629

Ryabov M.V.

Skobelkin Scientific and Practical Center for Laser Medicine of the Federal Medical Biological Agency

ORCID: 0000-0003-3942-3783

Received:

01.06.2023

Accepted:

31.07.2023

List of references:

Zlokachestvennye novoobrazovaniya v Rossii v 2020 godu (zabolevaemost’ i smertnost’). Pod red. Kaprina A.D., Starinskogo V.V., SHahzadovoj A.O. M.: MNIOI im. P.A. Gercena — filial FGBU «NMIC radiologii» Minzdrava Rossii; 2021. (In Russ.).
Timurzieva AB. The use of Raman fluorescence technologies in the early diagnosis of inflammatory and neoplastic diseases as part of a strategic direction in Public Health and a tool for improving the quality of medical care. Lazernaja medicina. 2021;25(4):42-50. (In Russ.). https://doi.org/10.37895/2071-8004-2021-25-4-42-50
Reshetov IV. Opuholi organov golovy i shei: tekhnologiya lecheniya i reabilitacii pacientov: rekonstrukciya tkanej. M., 2016. (In Russ.).
Rimskaya EN, Shchadko AO, Apollonova IA, et al. Differentiation of pigmented skin neoplasms based on digital processing of optical images. Optika i spektroskopija. 2019;126(5):584-595. (In Russ.). https://doi.org/10.21883/OS.2019.05.47657.6-19
Rossi AM, Sierra H, Rajadhyaksha M, Nehal K. Novel approaches to imaging basal cell carcinoma. Future Oncology. 2015;11(22):3039-3046. https://doi.org/10.2217/fon.15.231
Handbook of Optical Biomedical Diagnostics. Vol. 1. Light-Tissue Interaction. Tuchin VV, ed. SPIE Press. Bellingham, WA, USA; 2016.
Narayanamurthy V, Padmapriya P, Noorasafrin A, et al. Skin cancer detection using non-invasive techniques. RSC Advances. 2018;8(49):28095-28130. https://doi.org/10.1039/c8ra04164d
Liu CH, Wu B, Sordillo LA, et al. A pilot study for distinguishing basal cell carcinoma from normal human skin tissues using visible resonance Raman spectroscopy. Journal of Cancer Metastasis and Treatment. 2019;5:4. https://doi.org/10.20517/2394-4722.2018.55
Krišto M, Šitum M, Čeović R. Noninvasive Imaging Techniques for the Diagnosis of Nonmelanoma Skin Cancers. Acta Dermatovenerologica Croatica: ADC. 2020;28(3):157-165.
Warszawik-Hendzel O, Olszewska M, Maj M, et al. Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma. Journal of Dermatological Case Reports. 2015;9(4):89-97. https://doi.org/10.3315/jdcr.2015.1221
de Boer E, Moore LS, Warram JM, et al. On the horizon: Optical imaging for cutaneous squamous cell carcinoma. Head and Neck. 2016;38(suppl 1):2204-2213. https://doi.org/10.1002/hed.24079
Zakharov VP, Larin KV, Bratchenko IA. Increasing the information content of optical coherence tomography in diagnosing skin pathologies. Vestnik Samarskogo gosudarstvennogo ajerokosmicheskogo universiteta. 2011;26(2):232-239. (In Russ.).
Zakharov VP, Bratchenko IA, Myakinin OO, et al. Multimodal diagnostics and visualization of oncological pathologies. Kvantovaja Jelektronika. 2014;44(8):726-731. (In Russ.).
Bratchenko IA, Bratchenko LA, Khristoforova YA, et al. Classification of skin cancer using convolutional neural networks analysis of raman spectra. Computer Methods and Programs in Biomedicine. 2022;219:106755.
Schneider SL, Kohli I, Hamzavi IH, et al. Emerging imaging technologies in dermatology: Part I: Basic principles. Journal of the American Academy of Dermatology. 2019;80(4):1114-1120. https://doi.org/10.1016/j.jaad.2018.11.042
Schneider SL, Kohli I, Hamzavi IH, et al. Emerging imaging technologies in dermatology: Part II: Applications and limitations. Journal of the American Academy of Dermatology. 2019;80(4):1121-1131. https://doi.org/10.1016/j.jaad.2018.11.043
Levine A, Siegel D, Markowitz O. Imaging in cutaneous surgery. Future Oncology. 2017;13(26):2329-2340. https://doi.org/10.2217/fon-2017-0277
Cui S, Zhang S, Yue S. Raman Spectroscopy and Imaging for Cancer Diagnosis. Journal of Healthcare Engineering. 2018;2018:8619342. https://doi.org/10.1155/2018/8619342
Calin MA, Parasca SV, Savastru R, et al. Optical techniques for the noninvasive diagnosis of skin cancer. Journal of Cancer Research and Clinical Oncology. 2013;139(7):1083-10104. https://doi.org/10.1007/s00432-013-1423-3
Giuffrida R, Conforti C, Di Meo N, et al. Use of noninvasive imaging in the management of skin cancer. Current Opinion in Oncology. 2020;32(2):98-105. https://doi.org/10.1097/CCO.0000000000000611
Drakaki E, Vergou T, Dessinioti C, et al. Spectroscopic methods for the photodiagnosis of nonmelanoma skin cancer. Journal of Biomedical Optics. 2013;18(6):061221. https://doi.org/10.1117/1.JBO.18.6.061221
Boitor R, de Wolf C, Weesie F, et al. Clinical integration of fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma. Biomedical Optics Express. 2021;12(4): 2015-2026. https://doi.org/10.1364/BOE.417896
Lim L, Nichols B, Migden MR, et al. Clinical study of noninvasive in vivo melanoma and nonmelanoma skin cancers using multimodal spectral diagnosis. Journal of Biomedical Optics. 2014;19(11):117003. https://doi.org/10.1117/1.JBO.19.11.117003
Wang H, Zhao J, Lee AM, et al. Improving skin Raman spectral quality by fluorescence photobleaching. Photodiagnosis and Photodynamic Therapy. 2012;9(4):299-302. https://doi.org/10.1016/j.pdpdt.2012.02.001
Sinjab F, Kong K, Gibson G, et al. Tissue diagnosis using power-sharing multifocal Raman micro-spectroscopy and auto-fluorescence imaging. Biomedical Optics Express. 2016;7(8):2993-3006. https://doi.org/10.1364/BOE.7.002993
Jung S, Darvin ME, Schleusener J, et al. In vivo detection of changes in cutaneous carotenoids after chemotherapy using shifted excitation resonance Raman difference and fluorescence spectroscopy. Skin Research and Technology. 2020;26(2):301-307. https://doi.org/10.1111/srt.12800
Philipsen PA, Knudsen L, Gniadecka M, et al. Diagnosis of malignant melanoma and basal cell carcinoma by in vivo NIR-FT Raman spectroscopy is independent of skin pigmentation. Photochemical and Photobiological. 2013;12(5):770-776. Erratum in: Photochemical and Photobiological Sciences. 2014;13(9):1360. https://doi.org/10.1039/c3pp25344a
Sharma M, Marple E, Reichenberg J, Tunnell JW. Design and characterization of a novel multimodal fiber-optic probe and spectroscopy system for skin cancer applications. The Review of Scientific Instruments. 2014;85(8): 083101. https://doi.org/10.1063/1.4890199
Khristoforova YA, Bratchenko IA, Myakinin OO, et al. Portable spectroscopic system for in vivo skin neoplasms diagnostics by Raman and autofluorescence analysis. Journal of Biophotonics. 2019;12(4):e201800400. https://doi.org/10.1002/jbio.201800400
Huang Z, Lui H, McLean DI, et al. Raman spectroscopy in combination with background near-infrared autofluorescence enhances the in vivo assessment of malignant tissues. Photochemistry and Photobiology. 2005;81(5):1219-1226. https://doi.org/10.1562/2005-02-24-RA-449
Boitor R, Kong K, Shipp D, et al. Automated multimodal spectral histopathology for quantitative diagnosis of residual tumor during basal cell carcinoma surgery. Biomedical Optics Express. 2017;8(12):5749-5766. https://doi.org/10.1364/BOE.8.005749
Bodanese B, Silveira FL, Zângaro RA, et al. Discrimination of basal cell carcinoma and melanoma from normal skin biopsies in vitro through Raman spectroscopy and principal component analysis. Photomedicine and Laser Surgery. 2012;30(7):381-387. https://doi.org/10.1089/pho.2011.3191

Close metadata