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Golovatyuk K.A.

Almazov National Medical Research Center

Karonova T.L.

Institute of Endocrinology of the Almazov National Medical Research Centre

Mikhailova A.A.

Russian research center of surgery named after academician B.V. Petrovsky;
The Moscow state medical University named after A.I. Evdokimov of the Ministry of health of Russia

Lagutina D.I.

Almazov National Medical Research Center

Chernikova A.T.

Almazov National Medical Research Center

Vasilyeva E.Yu.

AO Kurort Belokurikha

Shlyakhto E.V.

Almazov National Medical Research Center

Cholecalciferol as part of complex therapy for acute COVID-19

Authors:

Golovatyuk K.A., Karonova T.L., Mikhailova A.A., Lagutina D.I., Chernikova A.T., Vasilyeva E.Yu., Shlyakhto E.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2022;25(12): 106‑113

DOI: 10.17116/profmed202225121106

Read: 1965 times

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Table of contents

CHOLECALCIFEROL AS PART OF COMPLEX THERAPY FOR ACUTE COVID-19
CHOLECALCIFEROL AS PART OF COMPLEX THERAPY FOR ACUTE COVID-19

To cite this article:

Golovatyuk KA, Karonova TL, Mikhailova AA, Lagutina DI, Chernikova AT, Vasilyeva EYu, Shlyakhto EV. Cholecalciferol as part of complex therapy for acute COVID-19. Russian Journal of Preventive Medicine. 2022;25(12):106‑113. (In Russ.)
https://doi.org/10.17116/profmed202225121106

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

During the pandemic of new coronavirus infection, the prevalence of moderate to severe vitamin D deficiency remains high, which is a factor worsening the course of COVID-19. According to some studies, cholecalciferol therapy, added to standard COVID-19 therapy, is associated with improving the course and prognosis of the disease.

OBJECTIVE

To evaluate the effect of cholecalciferol therapy at a dose of 100.000 IU on clinical and laboratory parameters in patients with moderate to severe COVID-19 admitted to an infectious hospital.

MATERIAL AND METHODS

An open single-center interventional study included 129 COVID-19 patients who were further randomized into two groups. Group 1 patients (n=65) received a total dose of 100.000 IU of cholecalciferol in addition to the standard COVID-19 therapy. Group 2 patients (n=64) received standard therapy only.

RESULTS

On day 9 of hospitalization, group 1 patients (receiving cholecalciferol) showed a 40.7% increase in serum 25(OH)D level, while group 2 patients (without cholecalciferol therapy) showed a negative trend (p<0.001). In addition, group 1 patients showed higher neutrophil and lymphocyte counts (p=0.047; p=0.025), and a lower level of C-reactive protein (p=0.028). A negative association was found between 25(OH)D levels and CRP values and between 25(OH)D levels and the length of hospital stay.

CONCLUSION

Adding cholecalciferol as a bolus dose to standard COVID-19 therapy has a positive effect on the disease’s clinical course and inflammatory markers’ levels.

Keywords:

COVID-19
vitamin D deficiency
25(OH)D
cholecalciferol
acute phase proteins

Authors:

Golovatyuk K.A.

Almazov National Medical Research Center

Karonova T.L.

Institute of Endocrinology of the Almazov National Medical Research Centre

Mikhailova A.A.

Russian research center of surgery named after academician B.V. Petrovsky;
The Moscow state medical University named after A.I. Evdokimov of the Ministry of health of Russia

Lagutina D.I.

Almazov National Medical Research Center

Chernikova A.T.

Almazov National Medical Research Center

Vasilyeva E.Yu.

AO Kurort Belokurikha

Shlyakhto E.V.

Almazov National Medical Research Center

Received:

18.09.2022

Accepted:

07.11.2022

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