The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Vertkin A.L.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Avdeev S.N.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Roitman E.V.

Pirogov Russian National Research Medical University;
Research Center of Neurology

Suchkov I.A.

Ryazan State Medical University

Kuznetsova I.V.

High Medical School

Zamyatin M.N.

National Medical and Surgical Center named after N.I. Pirogov

Stoyko Yu.M.

N.I. Pirogov National Medical and Surgical Center

Zhuravleva M.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Scientific Centre of Medical Application Expertise of the Ministry of the Healthcare of the Russian Federation

Zairatyants O.V.

Research Institute of Human Morphology;
Moscow State Medical and Dental University named after A.I. Evdokimov

Treatment of COVID-19 from the perspective of endotheliopathy correction and prevention of thrombotic complications. The agreed position of the experts

Authors:

Vertkin A.L., Avdeev S.N., Roitman E.V., Suchkov I.A., Kuznetsova I.V., Zamyatin M.N., Stoyko Yu.M., Zhuravleva M.V., Zairatyants O.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2021;24(4): 45‑51

DOI: 10.17116/profmed20212404145

Views: 2155

Downloaded: 136

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Vertkin AL, Avdeev SN, Roitman EV, et al. . Treatment of COVID-19 from the perspective of endotheliopathy correction and prevention of thrombotic complications. The agreed position of the experts. Russian Journal of Preventive Medicine. 2021;24(4):45‑51. (In Russ.)
https://doi.org/10.17116/profmed20212404145

 
МСФ на ЯМ
Close metadata
Recommended articles:
Causes of hospital mortality in adults based on medi­cal certificates of death. Russian Journal of Preventive Medi­cine. 2024;(3):7-13
Anti­biotic resi­stance of the upper respiratory tract microbiota in children with the new coro­navirus infe­ction in Ryazan. Russian Journal of Preventive Medi­cine. 2024;(3):45-51
Trends in the inci­dence of mental and beha­vioral diso­rders during the COVID-19 pandemic in Penza Oblast. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(2):129-134
Embo­lic Occlusion of Pulmonary Artery by Exte­nded Floating Clots as the most Severe Variant of Venous Thro­mboembolism. Journal of Venous Diso­rders. 2024;(1):14-25
Endo­thelial dysfunction as a pathogenetic factor of sensorineural hearing loss. Russian Bulletin of Otorhinolaryngology. 2024;(1):21-27
A clinical case of the new-onset bipo­lar affe­ctive diso­rder in the postcovid period. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3):125-129
Adve­rse peri­natal outcomes in COVID-19. Analysis of a series of clinical obse­rvations. Russian Bulletin of Obstetrician-Gynecologist. 2024;(2):86-90
Staging of COVID-19 morphological mani­festations in lungs depe­nding on disease dura­tion. Fore­nsic Medi­cal Expe­rtise. 2024;(2):28-31
Russian COVID-19 vaccines as a risk factor of myopericarditis in patients with or without previous infe­ction. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(2):184-193
Exosomes’ role in inte­rcellular inte­ractions in different variants of lung injury in fatal cases of COVID-19. Russian Journal of Archive of Pathology. 2024;(2):22-29

The proposed consensus position of the experts present approaches to the diagnosis, treatment and secondary prevention of thrombotic complications and endothelial dysfunction in COVID-19 for their use in outpatient visits. Experts confirmed the position of LMWH in hospitalized patients. Parnaparin sodium is the optimal choice for these patients, due to strong anti-inflammatory effect and a convenient dosing regimen. Experts confirmed endothelial damage as an important factor in the development of hypercoagulation in outpatients with COVID-19. According to expert’s consensus position, sulodexide may be a pathogenetic approach for the problem of endothelial dysfunction, especially — for period of convalescence. Experts recommend to introduce of sulodexide into the Temporary methodological recommendations of the Ministry of Health of the Russian Federation: for outpatients with light forms COVID-19, for patients with high risk of bleeding, also — for patients at the stage of rehabilitation to prevent recurrent VTE and reduce the risk of developing pulmonary fibrosis

Keywords:

coagulopathy
COVID-19
endothelial dysfunction
venous thromboembolism
parnaparin
sulodexide

Authors:

Vertkin A.L.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Avdeev S.N.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Roitman E.V.

Pirogov Russian National Research Medical University;
Research Center of Neurology

Suchkov I.A.

Ryazan State Medical University

Kuznetsova I.V.

High Medical School

Zamyatin M.N.

National Medical and Surgical Center named after N.I. Pirogov

Stoyko Yu.M.

N.I. Pirogov National Medical and Surgical Center

Zhuravleva M.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Scientific Centre of Medical Application Expertise of the Ministry of the Healthcare of the Russian Federation

Zairatyants O.V.

Research Institute of Human Morphology;
Moscow State Medical and Dental University named after A.I. Evdokimov

Received:

02.03.2021

Accepted:

02.03.2021

List of references:

  1. Zajrat’yants OV, Camsonova MV, Mihaleva LM, Chernyaev AL, Mishnev OD, Krupnov NM, Kalinin DV. Patologicheskaya anatomiya COVID-19: Atlas. Pod obshchej red. Zajrat’yanca O.V. M.: GBU «NIIOZMM DZM»; 2020. (In Russ.).
  2. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review. JAMA. 2020;324(8):782-793.  https://doi.org/10.1001/jama.2020.12839
  3. Abd El-Aziz TM, Stockand JD. Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) — an update on the status. Infect Genet Evol. 2020;83:104327. https://doi.org/10.1016/j.meegid.2020.104327
  4. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395(10229): 1054-1062.
  5. Hammer MM, Hunsaker AR, Gooptu M, Hatabu H. Frequency of Pulmonary Embolism in Patients With COVID-19. J Am Coll Cardiol Cardiovasc Imaging. 2020;13(11):2478-2479.
  6. Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E, Nigoghossian C, Ageno W, Madjid M, Guo Y, Tang LV, Hu Y, Giri J, Cushman M, Quéré I, Dimakakos EP, Gibson CM, Lippi G, Favaloro EJ, Fareed J, Caprini JA, Tafur AJ, Burton JR, Francese DP, Wang EY, Falanga A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Steg PG, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstantinides SV, Weitz JI, Lip GYH; Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function. COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;75:2950-2973.
  7. Iba T, Nisio MD, Levy JH, Kitamura N, Thachil J. New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. BMJ Open. 2017;7(9):e017046. https://doi.org/10.1136/bmjopen-2017-017046
  8. Popkin BM, Du S, Green WD, Beck MA, Algaith T, Herbst CH, Alsukait RF, Alluhidan M, Alazemi N, Shekar M. Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships. Obes Rev. 2020;21(11):e13128. https://doi.org/10.1111/obr.13128
  9. Diepstraten J. The influence of morbid obesity on the pharmacokinetics and pharmacodynamics of drugs in adolescents and adults: focus on propofol and nadroparin. Doctoral thesis. Leiden, Netherlands: Leiden University, Scholarly Publications; 2013. https://hdl.handle.net/1887/20959
  10. Imberti D, Legnani C, Baldini E, Cini M, Nicolini A, Guerra M, De Paoli M, Zanardi A, Palareti G. Pharmacodynamics of low molecular weight heparin in patients undergoing bariatric surgery: a prospective, randomised study comparing two doses of parnaparin (BAFLUX study). Thromb Res. 2009; 124(6):667-671.  https://doi.org/10.1016/j.thromres.2009.04.021
  11. Vremennye metodicheskie rekomendacii Ministerstva zdravoohraneniya RF. Profilaktika, diagnostika i lechenie novoj koronavirusnoj infekcii (COVID-19). Versiya 5 ot 08.04.20. Accessed March 03, 2021. (In Russ.). https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/052/550/original/%D0%9C%D0%A0_COVID-19_%28v9%29.pdf?1603788097
  12. Maugeri N, de Gaetano G, Barbanti M, Donati MB, Cerletti C. Prevention of platelet-polymorphonuclear leukocyte interactions: new clues to the antithrombotic properties of parnaparin, a low molecular weight heparin. Haematologica. 2005;90(6):833-839. 
  13. Maugeri N, Di Fabio G, Barbanti M, de Gaetano G, Donati MB, Cerletti C. Parnaparin, a low-molecular-weight heparin, prevents P-selectin dependent formation of platelet-leukocyte aggregates in human whole blood. Thromb Haemost. 2007;97(6):965-973.  https://doi.org/10.1160/th06-12-0680
  14. Chernyahovskaya NE, Shishlo VK, Povalyaev AV. Korrekciya mikrocirkulyacii v klinicheskoj praktike. M.: Binom; 2013. (In Russ.).
  15. Kuznetsova IV. Role ofpreconception endothelial dysfunction in development of obstetric complications. Medical alphabet. 2019;1(1):53-58. (In Russ.). https://doi.org/10.33667/2078-5631-2019-1-1(376)-53-58
  16. Kssja RJ, Greer IA. Manifestations of chronic disease during pregnancy. JAMA. 2005;294:2751-2757.
  17. Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, Newby LK, Piña IL, Roger VL, Shaw LJ, Zhao D, Beckie TM, Bushnell C, D’Armiento J, Kris-Etherton PM, Fang J, Ganiats TG, Gomes AS, Gracia CR, Haan CK, Jackson EA, Judelson DR, Kelepouris E, Lavie CJ, Moore A, Nussmeier NA, Ofili E, Oparil S, Ouyang P, Pinn VW, Sherif K, Smith SC Jr, Sopko G, Chandra-Strobos N, Urbina EM, Vaccarino V, Wenger NK. Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the american heart association. Circulation. 2011;123(11):1243-1262. https://doi.org/10.1161/CIR.0b013e31820faaf8
  18. Vaduganathan M, Vardeny O, Pharm D, Michel T, McMurray J, Pfeffer M, Solomon S. Renin—Angiotensin—Aldosterone System Inhibitors in Patients with Covid-19. N Engl J Med. 2020;382(17):1653-1659.
  19. Ratajczak MZ, Bujko K, Ciechanowicz A, Sielatycka K, Cymer M, Marlicz W, Kucia M. SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45- Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome. Stem Cell Rev Rep. 2021;17(1):266-277.  https://doi.org/10.1007/s12015-020-10010-z
  20. Masola V, Zaza G, Onisto M, Lupo A, Gambaro G. Glycosaminoglycans, proteoglycans and sulodexide and the endothelium: biological roles and pharmacological effects. Int Angiol. 2014;33(3):243-254. 
  21. Endermann DH. Endothelial Dysfunction. Journal of the American Society of Nephrology. 2004;15(8):1983-1992.
  22. Schutte AE, Harrison DG. Immunity, inflammation and the vasculature in the COVID-19 era. J Hypertens. 2020;38(9):1701-1702. https://doi.org/10.1097/HJH.0000000000002525
  23. Moore JB, June CH. Cytokine release syndrome in severe COVID-19. Science. 2020;368(6490):473-474.  https://doi.org/10.1126/science.abb8925
  24. Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020;383:120-128. 
  25. Becker BF, Jacob M, Leipert S, Salmon AH, Chappell D. Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases. Br J Clin Pharmacol. 2015;80(3):389-402.  https://doi.org/10.1111/bcp.12629
  26. Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J, Weber C, Bochaton-Piallat ML, Bäck M. Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Cardiovasc Res. 2020;116(14):2177-2184. https://doi.org/10.1093/cvr/cvaa230
  27. Cao RN, Tang L, Xia ZY, Xia R. Endothelial glycocalyx as a potential theriapeutic target in organ injuries. Chin Med J (Engl). 2019;132(8):963-975.  https://doi.org/10.1097/CM9.0000000000000177
  28. Walenga JM, Fareed J, Ramacciotti E. Sulodexide for the extended treatment of venous thromboembolism. Int Angiol. 2016;35(6):531-533. 
  29. Broekhuizen LN, Lemkes BA, Mooij HL, Meuwese MC, Verberne H, Holleman F, Schlingemann RO, Nieuwdorp M, Stroes ES, Vink H. Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus. Diabetologia. 2010;53(12):2646-2655.
  30. Mannello F, Ligi D, Canale M, Raffetto JD. Sulodexide down-regulates the release of cytokines, chemokines, and leukocyte colony stimulating factors from human macrophages: role of glycosaminoglycans in inflammatory pathways of chronic venous disease. Curr Vasc Pharmacol. 2014;12(1):173-185.  https://doi.org/10.2174/1570161111666131126144025
  31. Gonzalez-Ochoa AJ, Raffetto JD, Hernández AG, Zavala N, Gutiérrez O, Vargas A, Loustaunau J. Sulodexide in the treatment of patients with early stages of COVID-19: a randomized controlled trial. medRxiv. 2020. https://doi.org/10.1101/2020.12.04.20242073
  32. Andreozzi GM, Bignamini AA, Davì G, Palareti G, Matuška J, Holý M, Pawlaczyk-Gabriel K, Džupina A, Sokurenko GY, Didenko YP, Andrei LD, Lessiani G, Visonà A. Sulodexide for the Prevention of Recurrent Venous Thromboembolism. The Sulodexide in Secondary Prevention of Recurrent Deep Vein Thrombosis (SURVET) Study: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Circulation. 2015;132(20):1891-1897. https://doi.org/10.1161/CIRCULATIONAHA.115.016930
  33. Zolotnitskaya VP, Kuzubova NA, Titova ON, Surkova EA, Shumilov AA. An opportunity to improve pulmonary capillary circulation in patients with chronic obstructive pulmonary disease and comorbidity. Pulmonologiya. 2017; 27(6):767-775. (In Russ.). https://doi.org/10.18093/086930189320173273637673775
  34. Shevchenko YuL, Stojko YuM, Gudymovich VG, Chernyago TYu. Glikokaliks — opredelyayushchij faktor v razvitii endotelial’noj disfunkcii pri venoznoj patologii i vozmozhnosti ee korrekcii. Angiologiya i sosudistaya hirurgiya. 2020;26(4):71-76. (In Russ.).
  35. Kuznetsova IV, Gavrilova VA. Klinicheskij opyt korrekcii endotelial’noj disfunkcii na etape podgotovki k beremennosti bol’nyh sindromom polikistoznyh yaichnikov. Effektivnaya farmakoterapiya. 2020;16(28):36-41.  https://doi.org/10.33978/2307-3586-2020-16-28-36-41

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.