The importance of zinc in maintaining the activity of antiviral innate immunity proteins: analysis of publications on COVID-19

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Introduction. Compensation of concomitant micronutrient deficiencies is the most important area of support for antiviral innate immunity, especially in the context of the COVID-19 pandemic. The purpose of the work is to analyze all scientific publications on the study of coronaviruses available in PubMed databases. Material and methods. An analysis of 17,362 publications on coronaviruses (including 2,920 publications on the coronavirus SARS-CoV-2) was performed. The analysis was carried out using an artificial intelligence system. Results. It was shown that increasing the supply of human organisms with zinc, vitamins A, C, D, E is a promising approach for increasing resistance to SARS-CoV-2. The results of the proteome analysis confirm the importance of zinc as a cofactor of 118 proteins aimed at antiviral protection of the human body, including 11 interferon-I-dependent proteins against coronaviruses. Conclusion. The availability of zinc to the body can help inhibit the formation of the «cytokine storm» characteristic of COVID-19, reduce chronic systemic inflammation and compensate for comorbid pathologies, including cardiovascular, in patients with COVID-19.

Keywords:

zinc

coronaviruses

SARS-CoV-2

systems biology

machine learning

Zincit

Authors:

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

ORCID: 0000-0002-7663-710X

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

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