Objective — to study quality of life (QoL) and individual components of the psychosomatic status in patients with type 2 diabetes mellitus (T2DM) with macrovascular and microvascular complications. Subject and methods. The investigation enrolled 30 women and 22 men, who were diagnosed with T2DM at the age of 35 to 75 years. All the patients underwent a questionnaire survey, anthropometric measurements, and instrumental and biochemical studies. Hospital Anxiety and Depression Scale (HADS) was applied. QoL was assessed in patients with T2DM, by using the Short Form 36 (SF-36) questionnaire consisting of eight scales for two components. Results. Examinations revealed various microvascular and macrovascular complications in 40—50% of patients with diabetes mellitus lasting at least 8 years. Most patients had higher-than-reference glycated hemoglobin levels. Men received combined oral hypoglycemic therapy predominantly, while women more frequently took insulin as monotherapy and combined oral hypoglycemic therapy. In this case, most patients had first-degree obesity. At the time of the examination, patients had subclinical anxiety and depression. In general, the QoL in patients corresponded to the average level, while its individual components (such as the impact of physical and emotional status on the performance of daily duties) had noticeable limitations, (lower values); moreover, these indicators are more reduced in men than in women. In the aggregate, the physical QoL was 20% worse than the mental one. Conclusion. Thus, according to the questionnaire, certain QoL components and psychosomatic status are impaired in diabetic patients, which can be one of the important factors that affect life expectancy.