Telemedicine technologies can be one of the ways to improve the efficiency of treatment for hypertension. Objective — to investigate the use of an automatic blood pressure (BP) telemonitoring system (ABPTMS) in hypertensive patients during 24-week therapy; to elaborate an algorithm for the use of telemedicine technologies in clinical practice with the participation of a small innovative enterprise (SIE). Material and methods. The 24-week study included 77 patients with grade I—II hypertension who were divided into two groups. A T group included 35 people who were given autotonometers («Tensiophone», Hungary) within 12 weeks in order to transmit BP measurements by telephone. A K group consisted of 42 people who measured BP with their own tonometers at home. The conventional therapy selection scheme was used in the K group; a new treatment selection scheme was employed in the T group. The results of the investigation were used to build a business model for the introduction of ABPTMS in case of the Penza Region. The economic efficiency of attracting to the SIE project was studied. Results. After 24 weeks, 6 (14.3%) patients in the K group discontinued treatment on their own; all the patients in the T group continued to receive pharmacotherapy (p=0.02). The use of ABPTMS with treatment correction during telephone calls was accompanied by the better chances of achieving the target BP after 2 weeks of treatment (OR = 4; 95% CI, 1.68—9.53; p=0.002). The developed business model of ABPTMS involves the mandatory participation of the compulsory health insurance fund, patients and SIE, a developer and supplier of telemedicine services. The economic efficiency of the participation of a SIE is confirmed.by the example of the Penza Region. Conclusion. The use of ABPTMS in hypertensive patients contributed to a reduction in the timing of the selection of pharmacotherapy and high adherence to treatment. The introduction of the business model of ABPTMS into practice meets the interests of all its participants, including SIE.