Endometrial hyperplasia: modern concepts of etiopathogenesis

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Endometrial hyperplasia is one of the topical issues of modern gynecology due to the high incidence of this pathology, as well as the risk of malignant transformation of endometrial hyperplasia into endometrial cancer. Topic of etiopathogenesis of endometrial hyperplasia remains open: the role of the hyperestrogenemia in the development of endometrial hyperplastic processes is not being studied alone, but the contribution of endometrial microbiota, epigenetics and mutational alterations as well. In this regard, there is a necessity to revise approaches to the treatment of patients with verified endometrial hyperplasia. To date, only one drug has been registered for the treatment of endometrial hyperplasia, all other medications are used «off label» according to clinical recommendations.

Keywords:

endometrial hyperplasia

etiopathogenesis

risk factors

treatment

prevention

Authors:

Protasova A.E.

Federal State Budgetary Educational Institution of Higher Education "Saint-Petersburg State University";
Federal State Budgetary Educational Institution of Higher Education "National Medical Research Center Named After V.A. Almazov» of the Ministry of Health of Russia;
AVA-PETER

ORCID: 0000-0001-7930-8048

Adamyan L.V.

Moscow State Medical and Dental University named after A.I. Evdokimov

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

Sobivchak M.S.

Federal State Budgetary Educational Institution of Higher Education "Saint-Petersburg State University"

ORCID: 0009-0007-7239-7122

Tsypurdeeva A.A.

Federal State Budgetary Educational Institution of Higher Education "Saint-Petersburg State University";
Federal State Budgetary Scientific Institution «Scientific Research Institute of Obstetrics, Gynecology and Reproductology Named After A.I. Ott» of the Ministry of Education and Science of Russia

ORCID: 0000-0002-7022-0530

Received:

23.05.2023

Accepted:

25.05.2023

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