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Temirbulatov R.R.

JSC «International Centre for Reproductive Medicine» (Joint-Stock Company)

Isakova E.V.

International center for reproductive medicine

Korsak V.S.

International center for reproductive medicine

Effects of serum progesterone levels on the outcomes of assisted reproductive technology programs (literature review)

Authors:

Temirbulatov R.R., Isakova E.V., Korsak V.S.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(2): 102‑109

Read: 3365 times


To cite this article:

Temirbulatov RR, Isakova EV, Korsak VS. Effects of serum progesterone levels on the outcomes of assisted reproductive technology programs (literature review). Russian Journal of Human Reproduction. 2022;28(2):102‑109. (In Russ.)
https://doi.org/10.17116/repro202228021102

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References:

  1. Lawrenz B, Fatemi HM. Effect of progesterone elevation in follicular phase of IVF-cycles on the endometrial receptivity. Reproductive Biomedicine Online. 2017;34(4):422-428.  https://doi.org/10.1016/j.rbmo.2017.01.011
  2. Mityurina EV, Perminova SG, Durinyan ER, Ivanec TYu, Abubakirov AN. The effect of elevated progesterone concentrations on the day of ovulation trigger administration on the outcomes of IVF cycles in protocols with GnRH agonists. Akusherstvo i ginekologiya. 2014;6. (In Russ.).
  3. Devoto L, Fuentes A, Kohen P, Céspedes P, Palomino A, Pommer R, Muñoz A, Strauss JF 3rd. The human corpus luteum: life cycle and function in natural cycles. Fertility and Sterility. 2009;92(3):1067-1079. https://doi.org/10.1016/j.fertnstert.2008.07.1745
  4. Beckers NG, Macklon NS, Eijkemans MJ, Fauser BC. Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging. Fertility and Sterility 2002;78(2):291-297.  https://doi.org/10.1016/s0015-0282(02)03227-2
  5. Kolibianakis EM, Zikopoulos K, Smitz J, Camus M, Tournaye H, Van Steirteghem AC, Devroey P. Elevated progesterone at initiation of stimulation is associated with a lower ongoing pregnancy rate after IVF using GnRH antagonists. Human Reproduction. 2004;19(7): 1525-1529. https://doi.org/10.1093/humrep/deh272
  6. Mersereau JE, Evans ML, Moore DH, Liu JH, Thomas MA, Rebar RW, Pennington E, Cedars MI. Luteal phase estrogen is decreased in regularly menstruating older women compared with a reference population of younger women. Menopause. 2008;15(3):482-486.  https://doi.org/10.1097/gme.0b013e31815982cf
  7. van Zonneveld P, Scheffer GJ, Broekmans FJ, Blankenstein MA, de Jong FH, Looman CW, Habbema JD, te Velde ER. Do cycle disturbances explain the age-related decline of female fertility? Cycle characteristics of women aged over 40 years compared with a reference population of young women. Human Reproduction. 2003;18(3): 495-501.  https://doi.org/10.1093/humrep/deg138
  8. Huang JC, Jackson KV, Hornstein MD, Ginsburg ES. The effect of elevated serum progesterone during ovulation induction in in vitro fertilization-embryo transfer. Journal of Assisted Reproduction and Genetics. 1996;13(8):617-624.  https://doi.org/10.1007/BF02069639
  9. Sims JA, Seltman HJ, Muasher SJ. Early follicular rise of serum progesterone concentration in response to a flare-up effect of gonadotrophin-releasing hormone agonist impairs follicular recruitment for in-vitro fertilization. Human Reproduction. 1994;9(2):235-240.  https://doi.org/10.1093/oxfordjournals.humrep.a138488
  10. Tang Y, Gong F, Lin G, Lu G. Early follicular progesterone concentrations and in vitro fertilization pregnancy outcomes. Fertility and Sterility. 2007;87(4):991-994.  https://doi.org/10.1016/j.fertnstert.2006.08.087
  11. Tang Y, Gong F, Lin G, Lu G. Early follicular progesterone concentrations and in vitro fertilization pregnancy outcomes. Fertility and Sterility. 2007;87(4):991-994.  https://doi.org/10.1016/j.fertnstert.2006.08.087
  12. Hamdine O, Broekmans FJ, Eijkemans MJ, Lambalk CB, Fauser BC, Laven JS, Macklon NS; CETRO trial study group. Early initiation of gonadotropin-releasing hormone antagonist treatment results in a more stable endocrine milieu during the mid- and late-follicular phases: a randomized controlled trial comparing gonadotropin-releasing hormone antagonist initiation on cycle day 2 or 6. Fertility and Sterility. 2013;100(3):867-874.  https://doi.org/10.1016/j.fertnstert.2013.05.031
  13. Hamdine O, Macklon NS, Eijkemans MJ, Laven JS, Cohlen BJ, Verhoeff A, van Dop PA, Bernardus RE, Lambalk CB, Oosterhuis GJ, Holleboom CA, van den Dool-Maasland GC, Verburg HJ, van der Heijden PF, Blankhart A, Fauser BC, Broekmans FJ; CETRO trial study group. Elevated early follicular progesterone levels and in vitro fertilization outcomes: a prospective intervention study and meta-analysis. Fertility and Sterility. 2013;100(3):867-874.  https://doi.org/10.1016/j.fertnstert.2013.05.031
  14. Fanchin R, de Ziegler D, Taieb J, Hazout A, Frydman R. Premature elevation of plasma progesterone alters pregnancy rates of in vitro fertilization and embryo transfer. Fertility and Sterility. 1993;59(5): 1090-1094. https://doi.org/10.1016/s0015-0282(16)55933-0
  15. Ubaldi F, Bourgain C, Tournaye H, Smitz J, Van Steirteghem A, Devroey P. Endometrial evaluation by aspiration biopsy on the day of oocyte retrieval in the embryo transfer cycles in patients with serum progesterone rise during the follicular phase. Fertility and Sterility. 1997;67(3):521-526.  https://doi.org/10.1016/s0015-0282(97)80080-5
  16. Givens CR, Schriock ED, Dandekar PV, Martin MC. Elevated serum progesterone levels on the day of human chorionic gonadotropin administration do not predict outcome in assisted reproduction cycles. Fertility and Sterility. 1994;62(5):1011-1017. https://doi.org/10.1016/s0015-0282(16)57066-6
  17. Ubaldi F, Smitz J, Wisanto A, Joris H, Schiettecatte J, Derde MP, Borkham E, Van Steirteghem A, Devroey P. Oocyte and embryo quality as well as pregnancy rate in intracytoplasmic sperm injection are not affected by high follicular phase serum progesterone. Human Reproduction. 1995;10(12):3091-3096. https://doi.org/10.1093/oxfordjournals.humrep.a135864
  18. Kiliçdag EB, Haydardedeoglu B, Cok T, Hacivelioglu SO, Bagis T. Premature progesterone elevation impairs implantation and live birth rates in GnRH-agonist IVF/ICSI cycles. Archives of Gynecology and Obstetrics. 2010;281(4):747-752.  https://doi.org/10.1007/s00404-009-1248-0
  19. Santos-Ribeiro S, Polyzos NP, Haentjens P, Smitz J, Camus M, Tournaye H, Blockeel C. Live birth rates after IVF are reduced by both low and high progesterone levels on the day of human chorionic gonadotrophin administration. Human Reproduction. 2014; 29(8):1698-1705. https://doi.org/10.1093/humrep/deu151.
  20. Connell MT, Patounakis G, Healy MW, DeCherney AH, Devine K, Widra E, Levy MJ, Hill MJ. Is the effect of premature elevated progesterone augmented by human chorionic gonadotropin versus gonadotropin-releasing hormone agonist trigger? Fertility and Sterility. 2016;106(3):584-589.e1.  https://doi.org/10.1016/j.fertnstert.2016.04.024
  21. Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Jenkins J, Pellicer A. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Human Reproduction. 2010;25(8):2092-2100. https://doi.org/10.1093/humrep/deq125
  22. Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Human Reproduction. 2013;19(5):433-457.  https://doi.org/10.1093/humupd/dmt014
  23. Venetis CA, Kolibianakis EM, Papanikolaou E, Bontis J, Devroey P, Tarlatzis BC. Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis. Human Reproduction Update. 2007;13(4):343-355.  https://doi.org/10.1093/humupd/dmm007
  24. Filicori M, Cognigni GE, Pocognoli P, Tabarelli C, Spettoli D, Taraborrelli S, Ciampaglia W. Modulation of folliculogenesis and steroidogenesis in women by graded menotrophin administration. Human Reproduction. 2002;17(8):2009-2015. https://doi.org/10.1093/humrep/17.8.2009
  25. Kyrou D, Al-Azemi M, Papanikolaou EG, Donoso P, Tziomalos K, Devroey P, Fatemi HM. The relationship of premature progesterone rise with serum estradiol levels and number of follicles in GnRH antagonist/recombinant FSH-stimulated cycles. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2012; 162(2):165-168.  https://doi.org/10.1016/j.ejogrb.2012.02.025
  26. Lawrenz B, Beligotti F, Engelmann N, Gates D, Fatemi HM. Impact of gonadotropin type on progesterone elevation during ovarian stimulation in GnRH antagonist cycles. Human Reproduction. 2016;31(11):2554-2560. https://doi.org/10.1093/humrep/dew213
  27. Oktem O, Akin N, Bildik G, Yakin K, Alper E, Balaban B, Urman B. FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization. Human Reproduction. 2017;32(3):643-652.  https://doi.org/10.1093/humrep/dex010
  28. Moon YS, Tsang BK, Simpson C, Armstrong DT. 17 beta-Estradiol biosynthesis in cultured granulosa and thecal cells of human ovarian follicles: stimulation by follicle-stimulating hormone. The Journal of Clinical Endocrinology and Metabolism. 1978;47(2):263-267.  https://doi.org/10.1210/jcem-47-2-263
  29. Kyrou D, Kolibianakis EM, Fatemi HM, Tarlatzis BC, Tournaye H, Devroey P. Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial. Fertility and Sterility. 2011;96(5):1112-1115. https://doi.org/10.1016/j.fertnstert.2011.08.029
  30. Kolibianakis EM, Albano C, Camus M, Tournaye H, Van Steirteghem AC, Devroey P. Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists. Fertility and Sterility. 2004; 82(1):102-107.  https://doi.org/10.1016/j.fertnstert.2004.01.027
  31. Schneyer AL, Fujiwara T, Fox J, Welt CK, Adams J, Messerlian GM, Taylor AE. Dynamic changes in the intrafollicular inhibin/activin/follistatin axis during human follicular development: relationship to circulating hormone concentrations. The Journal of Clinical Endocrinology and Metabolism. 2000;85(9):3319-3330. https://doi.org/10.1210/jcem.85.9.6767
  32. Mityurina EV, Perminova SG, Demura TA, Gallyamova EV. Morphofunctional state of the endometrium in stimulated cycles of the in vitro fertilization program. Akusherstvo i ginekologiya. 2014;11:80-87. (In Russ.).
  33. Venetis CA, Kolibianakis EM, Bosdou JK, Lainas GT, Sfontouris IA, Tarlatzis BC, Lainas TG. Estimating the net effect of progesterone elevation on the day of hCG on live birth rates after IVF: a cohort analysis of 3296 IVF cycles. Human Reproduction. 2015;30(3): 684-691.  https://doi.org/10.1093/humrep/deu362
  34. Huang CC, Lien YR, Chen HF, Chen MJ, Shieh CJ, Yao YL, Chang CH, Chen SU, Yang YS. The duration of pre-ovulatory serum progesterone elevation before hCG administration affects the outcome of IVF/ICSI cycles. Human Reproduction. 2012;27(7):2036-2045. https://doi.org/10.1093/humrep/des141
  35. Hill MJ, Royster GD 4th, Healy MW, Richter KS, Levy G, DeCherney AH, Levens ED, Suthar G, Widra E, Levy MJ. Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation? Fertility and Sterility. 2015;103(6):1477-84.e845. https://doi.org/10.1016/j.fertnstert.2015.02.038
  36. Melo MA, Meseguer M, Garrido N, Bosch E, Pellicer A, Remohí J. The significance of premature luteinization in an oocyte-donation programme. Human Reproduction. 2006;21(6):1503-1507. https://doi.org/10.1093/humrep/dei474
  37. de Ziegler D, Pirtea P, Ayoubi JM. Outlining the practical options for coping with the shortcomings of vaginal progesterone recently unveiled in frozen embryo transfers: a story drafted in Turkey. Fertility and Sterility. 2022;117(1):38-39.  https://doi.org/10.1016/j.fertnstert.2021.08.048
  38. Labarta E, Mariani G, Holtmann N, Celada P, Remohí J, Bosch E. Low serum progesterone on the day of embryo transfer is associated with a diminished ongoing pregnancy rate in oocyte donation cycles after artificial endometrial preparation: a prospective study. Human Reproduction. 2017;32(12):2437-2442. https://doi.org/10.1093/humrep/dex316
  39. Alsbjerg B, Thomsen L, Elbaek HO, Laursen R, Povlsen BB, Haahr T, Humaidan P. Progesterone levels on pregnancy test day after hormone replacement therapy-cryopreserved embryo transfer cycles and related reproductive outcomes. Reproductive Biomedicine Online. 2018;37(5):641-647.  https://doi.org/10.1016/j.rbmo.2018.08.022
  40. Basnayake SK, Volovsky M, Rombauts L, Osianlis T, Vollenhoven B, Healey M. Progesterone concentrations and dosage with frozen embryo transfers — what’s best? The Australian and New Zealand Journal of Obstetrics and Gynaecology. 2018;58(5):533-538.  https://doi.org/10.1111/ajo.12757
  41. Brady PC, Kaser DJ, Ginsburg ES, Ashby RK, Missmer SA, Correia KF, Racowsky C. Serum progesterone concentration on day of embryo transfer in donor oocyte cycles. Journal of Assisted Reproduction and Genetics. 2014;31(5):569-575.  https://doi.org/10.1007/s10815-014-0199-y
  42. Cédrin-Durnerin I, Isnard T, Mahdjoub S, Sonigo C, Seroka A, Comtet M, Herbemont C, Sifer C, Grynberg M. Serum progesterone concentration and live birth rate in frozen-thawed embryo transfers with hormonally prepared endometrium. Reproductive Biomedicine Online. 2019;38(3):472-480.  https://doi.org/10.1016/j.rbmo.2018.11.026
  43. Gaggiotti-Marre S, Martinez F, Coll L, Garcia S, Álvarez M, Parriego M, Barri PN, Polyzos N, Coroleu B. Low serum progesterone the day prior to frozen embryo transfer of euploid embryos is associated with significant reduction in live birth rates. Gynecological Endocrinology. 2019;35(5):439-442.  https://doi.org/10.1080/09513590.2018.1534952
  44. Labarta E, Mariani G, Paolelli S, Rodriguez-Varela C, Vidal C, Giles J, Bellver J, Cruz F, Marzal A, Celada P, Olmo I, Alamá P, Remohi J, Bosch E. Impact of low serum progesterone levels on the day of embryo transfer on pregnancy outcome: a prospective cohort study in artificial cycles with vaginal progesterone. Human Reproduction. 2021;36(3):683-692.  https://doi.org/10.1093/humrep/deaa322
  45. Polat M, Mumusoglu S, Bozdag G, Ozbek IY, Humaidan P, Yarali H. Addition of intramuscular progesterone to vaginal progesterone in hormone replacement therapy in vitrified-warmed blastocyst transfer cycles. Reproductive Biomedicine Online. 2020;40(6):812-818.  https://doi.org/10.1016/j.rbmo.2020.01.031
  46. Yovich JL, Conceicao JL, Stanger JD, Hinchliffe PM, Keane KN. Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement. Reproductive Biomedicine Online. 2015;31(2):180-191.  https://doi.org/10.1016/j.rbmo.2015.05.005
  47. Yarali H, Polat M, Mumusoglu S, Ozbek IY, Erden M, Bozdag G, Humaidan P. Subcutaneous luteal phase progesterone rescue rectifies ongoing pregnancy rates in hormone replacement therapy vitrified-warmed blastocyst transfer cycles. Reproductive Biomedicine Online. 2021;43(1):45-51.  https://doi.org/10.1016/j.rbmo.2021.04.011
  48. Mumusoglu S, Polat M, Ozbek IY, Bozdag G, Papanikolaou EG, Esteves SC, Humaidan P, Yarali H. Preparation of the Endometrium for Frozen Embryo Transfer: A Systematic Review. Frontiers in Endocrinology. 2021;12:688237. https://doi.org/10.3389/fendo.2021.688237
  49. Álvarez M, Gaggiotti-Marre S, Martínez F, Coll L, García S, González-Foruria I, Rodríguez I, Parriego M, Polyzos NP, Coroleu B. Individualised luteal phase support in artificially prepared frozen embryo transfer cycles based on serum progesterone levels: a prospective cohort study. Human Reproduction. 2021;36(6):1552-1560. https://doi.org/10.1093/humrep/deab031
  50. Turgut EN, Boynukalın FK, Gültomruk M, Yarkıner Z, Bahçeci M. Comparison of intramuscular versus subcutaneous aqueous progesterone for luteal phase support in artificially prepared frozen embryo transfer cycles. Turkish Journal of Obstetrics and Gynecology. 2020; 17(4):240-246.  https://doi.org/10.4274/tjod.galenos.2020.01460
  51. Devine K, Richter KS, Jahandideh S, Widra EA, McKeeby JL. Intramuscular progesterone optimizes live birth from programmed frozen embryo transfer: a randomized clinical trial. Fertility and Sterility. 2021;116(3):633-643.  https://doi.org/10.1016/j.fertnstert.2021.04.013

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