Predictive role of gynecological and extragenital pathology in patients with proliferative diseases of endocervix

Dobrokhotova Yu.E.; Kononova I.N.; Kareva E.N.; Nazhipova E.V.

doi:https://doi.org/10.17116/repro20212701153

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

SPIN RSCI: 2925-9948
Scopus AuthorID: 57188592250
ORCID: 0000-0002-7830-2290

Kononova I.N.

Interregional Center for Continuing Professional Education

Kareva E.N.

Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation;
First Moscow State Medical University of the Ministry of Health of the Russian Federation

SPIN RSCI: 2105-2701
Scopus AuthorID: 6701781417
ResearcherID: E-9011-2014
ORCID: 0000-0002-9441-3468

Nazhipova E.V.

Urals Scientific Research Institute for Maternal and Child Care

Predictive role of gynecological and extragenital pathology in patients with proliferative diseases of endocervix

Authors:

Dobrokhotova Yu.E., Kononova I.N., Kareva E.N., Nazhipova E.V.

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Journal: Russian Journal of Human Reproduction. 2021;27(1): 53‑58

DOI: 10.17116/repro20212701153

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To cite this article:

Dobrokhotova YuE, Kononova IN, Kareva EN, Nazhipova EV. Predictive role of gynecological and extragenital pathology in patients with proliferative diseases of endocervix. Russian Journal of Human Reproduction. 2021;27(1):53‑58. (In Russ.)
https://doi.org/10.17116/repro20212701153

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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PURPOSE OF THE STUDY

Identification of the predictor role of gynecological and extragenital pathology in patients with endocervix polyps to identify risk groups.

MATERIAL AND METHODS

A retrospective analysis of the gynecological and somatic history of 143 patients with endocervix polyps aged 18 to 60 years was conducted in the clinical diagnostic department of the Research Institute of Urals Scientific Research Institute for Maternal and Child Care, Central City Clinical Hospital No. 24 of Yekaterinburg for the period 2014-2019. The control group consisted of 73 women.

RESULTS AND DISCUSSION

As a result of the study, a high positive correlation was found between endocrine diseases and endocervix polyps (r=+0.72; p=0.018), RR=3.92 at p=0.000, with dominance in the spectrum of thyroid diseases. In 72.7±6.4% of women, endocervix polyps were combined with other gynecological diseases, in particular with inflammatory processes of the pelvic organs (RR=6.172 at p=0.006) and hormone-associated gynecological diseases (R=8.13 at p=0.001), a high positive correlation between endocervix polyps and endometrial hyperplastic processes was revealed (r=+0.79; p=0.001).

CONCLUSIONS

The results indicate a predictor role of both somatic, to a greater extent, endocrine diseases (RR=3.92 (95% CI 1.25-5.24, χ²=12.314 at p=0.000, and hormone-associated gynecological diseases RR=4.258 (95% CI 1.35-7.23, χ²=5.327 at p=0.008, as well as inflammatory diseases of the pelvic organs in the genesis of the endocervix polyp (RR=6.172 (95% CI 3.25-8.68, χ²=6.253 at p=0.006), which characterizes this disease as multifactorial and dictates the need for a comprehensive examination of patients with identification of risk groups according to the results of the revealed diseases, personalized correction of existing violations in the postoperative period for the prevention of recurrence of the proliferative process.

Keywords:

endocervical polyp

predictors

gynecological diseases

endocrine diseases

Authors:

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

SPIN RSCI: 2925-9948
Scopus AuthorID: 57188592250
ORCID: 0000-0002-7830-2290

Kononova I.N.

Interregional Center for Continuing Professional Education

Kareva E.N.

Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation;
First Moscow State Medical University of the Ministry of Health of the Russian Federation

SPIN RSCI: 2105-2701
Scopus AuthorID: 6701781417
ResearcherID: E-9011-2014
ORCID: 0000-0002-9441-3468

Nazhipova E.V.

Urals Scientific Research Institute for Maternal and Child Care

Received:

18.03.2020

Accepted:

16.05.2020

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