Predictive role of gynecological and extragenital pathology in patients with proliferative diseases of endocervix

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

SPIN RSCI: 2925-9948
Scopus AuthorID: 57188592250
ORCID: 0000-0002-7830-2290

Kononova I.N.

Interregional Center for Continuing Professional Education

Kareva E.N.

Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation;
First Moscow State Medical University of the Ministry of Health of the Russian Federation

SPIN RSCI: 2105-2701
Scopus AuthorID: 6701781417
ResearcherID: E-9011-2014
ORCID: 0000-0002-9441-3468

Nazhipova E.V.

Urals Scientific Research Institute for Maternal and Child Care

Predictive role of gynecological and extragenital pathology in patients with proliferative diseases of endocervix

Authors:

Dobrokhotova Yu.E., Kononova I.N., Kareva E.N., Nazhipova E.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2021;27(1): 53‑58

DOI: 10.17116/repro20212701153

Downloaded: 22

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Dobrokhotova YuE, Kononova IN, Kareva EN, Nazhipova EV. Predictive role of gynecological and extragenital pathology in patients with proliferative diseases of endocervix. Russian Journal of Human Reproduction. 2021;27(1):53‑58. (In Russ.)
https://doi.org/10.17116/repro20212701153

Подписка 2025-2 (Russian Journal of Human Reproduction)

Close metadata

PURPOSE OF THE STUDY

Identification of the predictor role of gynecological and extragenital pathology in patients with endocervix polyps to identify risk groups.

MATERIAL AND METHODS

A retrospective analysis of the gynecological and somatic history of 143 patients with endocervix polyps aged 18 to 60 years was conducted in the clinical diagnostic department of the Research Institute of Urals Scientific Research Institute for Maternal and Child Care, Central City Clinical Hospital No. 24 of Yekaterinburg for the period 2014-2019. The control group consisted of 73 women.

RESULTS AND DISCUSSION

As a result of the study, a high positive correlation was found between endocrine diseases and endocervix polyps (r=+0.72; p=0.018), RR=3.92 at p=0.000, with dominance in the spectrum of thyroid diseases. In 72.7±6.4% of women, endocervix polyps were combined with other gynecological diseases, in particular with inflammatory processes of the pelvic organs (RR=6.172 at p=0.006) and hormone-associated gynecological diseases (R=8.13 at p=0.001), a high positive correlation between endocervix polyps and endometrial hyperplastic processes was revealed (r=+0.79; p=0.001).

CONCLUSIONS

The results indicate a predictor role of both somatic, to a greater extent, endocrine diseases (RR=3.92 (95% CI 1.25-5.24, χ²=12.314 at p=0.000, and hormone-associated gynecological diseases RR=4.258 (95% CI 1.35-7.23, χ²=5.327 at p=0.008, as well as inflammatory diseases of the pelvic organs in the genesis of the endocervix polyp (RR=6.172 (95% CI 3.25-8.68, χ²=6.253 at p=0.006), which characterizes this disease as multifactorial and dictates the need for a comprehensive examination of patients with identification of risk groups according to the results of the revealed diseases, personalized correction of existing violations in the postoperative period for the prevention of recurrence of the proliferative process.

Keywords:

endocervical polyp

predictors

gynecological diseases

endocrine diseases

Authors:

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

SPIN RSCI: 2925-9948
Scopus AuthorID: 57188592250
ORCID: 0000-0002-7830-2290

Kononova I.N.

Interregional Center for Continuing Professional Education

Kareva E.N.

Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation;
First Moscow State Medical University of the Ministry of Health of the Russian Federation

SPIN RSCI: 2105-2701
Scopus AuthorID: 6701781417
ResearcherID: E-9011-2014
ORCID: 0000-0002-9441-3468

Nazhipova E.V.

Urals Scientific Research Institute for Maternal and Child Care

Received:

18.03.2020

Accepted:

16.05.2020

List of references:

Aksel EM, Vinogradova NN. Statistics of malignant neoplasms of female reproductive organs. Onkoginekologiya. 2018;3:64-69. (In Russ.). https://osors.ru/oncogynecology/JurText/j2018_3/03_18_64.pdf
WHO/ICO Information Centre on HPV and Cancer. Russian Federation: Human Papillomavirus and Related Cancers. Fact Sheet 2016. Accessed December 10, 2020. https://www.hpvcentre.net
Krasnopolsky VI. Obligatnye formy predraka i invazivnyj rak shejki matki: rukovodstvo dlya vrachej. M.: SIMK; 2017. (In Russ.).
Boyko MA, Mamikonyan IO, Sattarov ShN, Gus AI, Sarkisov SE. Diagnostic efficiency of transvaginal echography and cervical hysteroscopy in the detection of polyps of the mucosa of the cervical canal. Akusherstvo i ginekologiya. 2013;8:68-73. (In Russ.).
Rogovskaya SI. Shejka matki, vlagalishche, vul’va. Fiziologiya, patologiya, kol’poskopiya, esteticheskaya korrektsiya: rukovodstvo dlya praktikuyushchikh vrachej. Rogovskaya SI, Lipova EV, eds. M.: StatusPraesens; 2016. (In Russ.).
Mackenzie IK, Naish C, Rees CMP, Manek S. Why remove all cervical polyps and examine them histologically? BJOG: British Journal of Obstetrics and Gynaecology. 2009;116(8):1127-1129. https://doi.org/10.1111/j.1471-0528.2009.02169.x
Esim Buyukbayrak E, Karageyim Karsidag AY, Kars B, Sakin O, Ozyapi Alper AG, Pirimoglu M, Unal O, Turan C. Cervical polyps: evaluation of routine removal and need for accompanying D&C. Archives of Gynecology and Obstetrics. 2011;283(3):581-584. https://doi.org/10.1007/s00404-010-1405-5
Kira EF, Sinchikhin SP, Stepanyan LV, Mamiev OB. Osnovnye voprosy onkoginekologii: uchebnik na anglijskom i russkom yazykakh. M.: GEOTAR-Media; 2018. (In Russ.).
Tirlapur SA, Adeyemo A, O’Gorman N, Selo-Ojeme D. Clinico-pathological study of cervical polyps. Archives of Gynecology and Obstetrics. 2010;282(5):535-538. https://doi.org/10.1007/s00404-010-1364-x
Stamatellos I, Stamatopoulos P, Bontis J. The role of hysteroscopy in the current management of the cervical polyps. Archives of Gynecology and Obstetrics. 2007;276(4):299-303. https://doi.org/10.1007/s00404-007-0417-2
Kononova IN, Voroshilina ES. Features of local immunity in cervical intraepithelial neoplasias associated with human papillomavirus infection. Rossijskij immunologicheskij zhurnal. 2014;17(3): 809-811. (In Russ.).
Oboskalova TA, Kononova IN, Voroshilina ES, Kuzina TV. The effectiveness of rehabilitation measures after destructive methods of therapy in patients with cervical pathology associated with human papillomavirus infection. Akusherstvo i ginekologiya. 2012;2:86-89. (In Russ.).
Rexhepi M, Trajkovska E, Koprivnjak K. An Unusually Large Fibroepithelial Polyp of Uterine Cervix: Case Report and Review of Literature. Open Access Macedonian Journal of Medical Sciences. 2019;7(12):1998-2001. https://doi.org/10.3889/oamjms.2019.102
Berzolla CE, Schnatz PF, O’Sullivan DM, Bansal R, Mandavilli S, Sorosky JL. Dysplasia and malignancy in endocervical polyps. Journal of Women’s Health. 2007;16(9):1317-1321. https://doi.org/10.1089/jwh.2007.0408
Kareva EN, Gankovskaya LV, Shimanovsky NL. Sex steroids and immunity. Rossijskij immunologicheskij zhurnal. 2012;6(15):3-13. (In Russ.).
Mamaev AN. Osnovy meditsinskoj statistiki. M.: Prakticheskaya meditsina; 2011. (In Russ.).
Gothwal M, Singh P, Bharti JN, Yadav G, Solanki V. Giant Cervical Angiomyomatous Polyp Masquerading Third-Degree Uterine Prolapse: A Rare Case with Review of Literature. International Journal of Applied and Basic Medical Research. 2019;9(4):256-258. https://doi.org/10.4103/ijabmr.IJABMR_386_18
Kareva EN, Serebrova SYu, Bulgakova VA, Kononova IN, Oleinikova OM, Mazitova MI, Fisenko VP. Selective Modulators of Thyroid Hormone Receptors (literature review). Eksperimental’naya i klinicheskaya farmakologiya. 2019;82(9):26-35. (In Russ). https://doi.org/10.30906/0869-2092-2019-82-9-26-35
Massinde AN, Mpogoro F, Rumanyika RN, Magoma M. Uterine prolapse complicated with a giant cervical polyp. Journal of Lower Genital Tract Disease. 2012;16(1):64-65. https://doi.org/10.1097/LGT0b013e31822b752d
Younis MT, Iram S, Anwar B, Ewies AA. Women with asymptomatic cervical polyps may not need to see a gynaecologist or have them removed: an observational retrospective study of 1126 cases. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2010;150(2):190-194. https://doi.org/10.1016/j.ejogrb.2010.02.020
Kononova IN, Kareva EN. Local antibiotic therapy in the complex treatment of patients with HPV-associated cervical diseases. Akusherstvo i ginekologiya. 2018;4:103-107. (In Russ). https://doi.org/10.18565/aig.2018.7.103-107
Numakura K, Tsuchiya N, Inoue T, Horikawa Y, Kakinuma H, Togashi H, Matsuura S, Ohyama C, Satoh S, Sato K, Habuchi T, Noto H. A case of fibroepithelial polyp of the ureter resected ureteroscopically. Hinyokika Kiyo. Acta Urologica Japonica. 2005;51(4): 277-281.
Bucella D, Frédéric B, Noël JC. Giant cervical polyp: a case report and review of a rare entity. Archives of Gynecology and Obstetrics. 2008;278(3):295-298. https://doi.org/0.1007/s00404-008-0575-x
Mitra A, Yun L, Macintyre D. Assessment of the vaginal microbiome with bacterial DNA pyrosequencing assording to CIN grade and severity. Abstracts of the 15 Wold Congress for Cervical Pathology and Colposcopy. 2014:123-124.

Close metadata