Factors determining the effectiveness of ARTs: a review of the literature

Boyarsky K.Y.; Semenenko A.E.; Kriazheva E.A.; Khan T.V.; Kakhiani E.I.

doi:https://doi.org/10.17116/repro20253106146

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Сравнительный анализ рецептивности эндометрия у молодых женщин с эндометриальным и овариальным факторами инфертильности. Архив патологии. 2026;(1):26-34

Резюме / Abstract:

Факторы, от которых зависит эффективность процедур вспомогательных репродуктивных технологий, многочисленны и до конца не изучены. В обзоре представлен анализ данных, согласно которым основную роль играет эуплоидный эмбрион (с нормальным хромосомным набором), а вероятность его получения зависит от возраста пациентки и показателей овариального резерва. Несомненную роль также играют гинекологические заболевания, ассоциированные с бесплодием, такие как миома матки, наружный генитальный эндометриоз, аденомиоз, наличие гидросальпинкса, синдрома Ашермана и хронического эндометрита. В обзоре критически рассматриваются тесты, определяющие рецептивность эндометрия.

Ключевые слова / Keywords:

эффективность вспомогательных репродуктивных технологий

ВРТ

овариальный резерв

гинекологические заболевания

рецептивность эндометрия

Авторы / Authors:

Боярский К.Ю.

ООО «Генезис»;
ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России

ORCID: 0000-0002-2000-1567

Семененко А.Е.

ООО «Генезис»

ORCID: 0009-0008-8767-1638

Кряжева Е.А.

ООО «Генезис»

ORCID: 0009-0006-7183-7571

Хан Т.В.

ООО «Генезис»

ORCID: 0009-0007-5423-8806

Кахиани Е.И.

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России

ORCID: 0000-0002-0410-817X

Дата поступления:

22.05.2024

Дата принятия в печать:

06.02.2025

Закрыть метаданные

Литература / References:

Pirtea P, De Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, Seli E, Franasiak JM, Scott RT Jr. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertility and Sterility. 2021;115(1):45-53. https://doi.org/10.1016/j.fertnstert.2020.07.002
McCoy RC. Mosaicism in Preimplantation Human Embryos: When Chromosomal Abnormalities Are the Norm. Trends In Genetics. 2017;33(7):448-463. https://doi.org/10.1016/j.tig.2017.04.001
Esteves SC, Carvalho JF, Bento FC, Santos J. A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertilization/Intracytoplasmic Sperm Injection: The ART Calculator. Frontiers in Endocrinology (Lausanne). 2019;10:99. https://doi.org/10.3389/fendo.2019.00099
Ata B, Kalafat E, Somigliana E. A new definition of recurrent implantation failure on the basis of anticipated blastocyst aneuploidy rates across female age. Fertility and Sterility. 2021;116(5):1320-1327. https://doi.org/10.1016/j.fertnstert.2021.06.045
Kotlyar AM, Seifer DB. Ethnicity/Race and Age-Specific Variations of Serum AMH in Women — A Review. Frontiers in Endocrinology (Lausanne). 2021;11:593216. https://doi.org/10.3389/fendo.2020.593216
La Marca A, Sunkara SK. Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice. Human Reproduction Update. 2014;20(1):124-140. https://doi.org/10.1093/humupd/dmt037
Yovich JL, Hinchliffe PM, Lingam S, Srinivasan S, Keane KN. Adjusting the PIVET rFSH dosing algorithm for the biosimilar Bemfola product. Journal of Fertilization. 2018;5(3):1-4. https://doi.org/10.1016/j.jfiv.2018.05.001
Arce JC, Andersen AN, Fernández-Sánchez M, Visnova H, Bosch E, García-Velasco JA, Fauser BC. Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimüllerian hormone-stratified, dose–response trial in women undergoing in vitro fertilization/intracytoplasmic sperm injection. Fertility and Sterility. 2014;102(6):1633-1640. https://doi.org/10.1016/j.fertnstert.2014.08.013
Sunkara SK, Rittenberg V, Raine-Fenning N, Bhattacharya S, Zamora J, Coomarasamy A. Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles. Human Reproduction. 2011;26(7):1768-1774. https://doi.org/10.1093/humrep/der106
Rodríguez-Varela C, Mascarós JM, Labarta E, Silla N, Bosch E. Minimum number of mature oocytes needed to obtain at least one euploid blastocyst according to female age in in vitro fertilization treatment cycles. Fertility and Sterility. 2024;122(4):658-666. https://doi.org/10.1016/j.fertnstert.2024.06.00211)
Jia L, Chen PY, Guo YC, Zhang ZQ, Gong X, Chen JB, Fang C. Prediction of cumulative live birth rate in women aged 40 years and over undergoing in vitro fertilization/intracytoplasmic sperm injection. Reproductive and Developmental Medicine. 2020;4(04):235-240. https://doi.org/10.4103/2096-2924.305931
Stojnic J, Bila J, Tulic L, Micic J, Andjic M, Pupovac M, Likic Ladjevic I, Tosic T, Dotlic J. Severe Hemoperitoneum due to Ovarian Bleeding after Transvaginal Oocyte Retrieval with Surgical Management: A Retrospective Analysis and Comprehensive Review of the Literature. Medicina (Kaunas). 2023;59(2):307. https://doi.org/10.3390/medicina59020307
Bai X, Lin Y, Chen Y, Ma C. The impact of FIGO type 3 fibroids on in-vitro fertilization outcomes: A nested retrospective case-control study. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2020;247:176-180. https://doi.org/10.1016/j.ejogrb.2019.12.018
Favilli A, Etrusco A, Chiantera V, Laganà AS, Cicinelli E, Gerli S, Vitagliano A. Impact of FIGO type 3 uterine fibroids on in vitro fertilization outcomes: A systematic review and meta-analysis. International Journal of Gynaecology and Obstetrics. 2023;163(2):528-539. https://doi.org/10.1002/ijgo.14838
Rikhraj K, Tan J, Taskin O, Albert AY, Yong P, Bedaiwy MA. The Impact of Noncavity-Distorting Intramural Fibroids on Live Birth Rate in In Vitro Fertilization Cycles: A Systematic Review and Meta-Analysis. Journal of Women’s Health. 2020;29(2):210-219. https://doi.org/10.1089/jwh.2019.7813
Erden M, Uyanik E, Polat M, Ozbek IY, Yarali H, Mumusoglu S. The effect of ≤6 cm sized noncavity-distorting intramural fibroids on in vitro fertilization outcomes: a systematic review and meta-analysis. Fertility and Sterility. 2023;119(6):996-1007. https://doi.org/10.1016/j.fertnstert.2023.02.018
Zhang H, He X, Tian W, Song X, Zhang H. Hysteroscopic Resection of Endometrial Polyps and Assisted Reproductive Technology Pregnancy Outcomes Compared with No Treatment: A Systematic Review. Journal of Minimally Invasive Gynecology. 2019;26(4):618-627. https://doi.org/10.1016/j.jmig.2018.10.024
Liang J, Li M, Zhang L, Yang Y, Jin X, Zhang Q, Lv T, Huang Z, Liao Q, Tong X. Analysis of the microbiota composition in the genital tract of infertile patients with chronic endometritis or endometrial polyps. Frontiers in Cellular and Infection Microbiology. 2023; 13:1125640. https://doi.org/10.3389/fcimb.2023.1125640
Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F. The Effect of Uterine Adenomyosis on IVF Outcomes: a Systematic Review and Meta-analysis. Reproductive Sciences. 2022; 29(11):3177-3193. https://doi.org/10.1007/s43032-021-00818-6
Mishra I, Melo P, Easter C, Sephton V, Dhillon-Smith R, Coomarasamy A. Prevalence of adenomyosis in women with subfertility: systematic review and meta-analysis. Ultrasound In Obstetrics and Gynecology. 2023;62(1):23-41. https://doi.org/10.1002/uog.26159
Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, King K, Kvaskoff M, Nap A, Petersen K, Saridogan E, Tomassetti C, van Hanegem N, Vulliemoz N, Vermeulen N. ESHRE guideline: endometriosis. Human Reproduction Open. 2022;2022(2): hoac009. https://doi.org/10.1093/hropen/hoac009
Invernici D, Reschini M, Benaglia L, Somigliana E, Galati G, La Vecchia I, Vigano’ P, Vercellini P. The impact of endometriosis on IVF efficacy: qualitative and quantitative assessment of ovarian response and embryo development. Reproductive Biomedicine Online. 2022;45(2):275-281. https://doi.org/10.1016/j.rbmo.2022.04.010
Qu H, Du Y, Yu Y, Wang M, Han T, Yan L. The effect of endometriosis on IVF/ICSI and perinatal outcome: A systematic review and meta-analysis. Journal of Gynecology Obstetrics and Human Reproduction. 2022;51(9):102446. https://doi.org/10.1016/j.jogoh.2022.102446
Hanstede MMF, van der Meij E, Veersema S, Emanuel MH. Live births after Asherman syndrome treatment. Fertility and Sterility. 2021;116(4):1181-1187. https://doi.org/10.1016/j.fertnstert.2021.05.099
Santamaria X, Liu JH, Aghajanova L, Isaacson K, Movilla P, Fernandez H, Capmas P, Donnez J, Simón C. Should we consider alternative therapies to operative hysteroscopy for the treatment of Asherman syndrome? Fertility and Sterility. 2020;113(3):511-521. https://doi.org/10.1016/j.fertnstert.2020.01.022
Movilla P, Wang J, Chen T, Morales B, Wang J, Williams A, Reddy H, Tavcar J, Loring M, Morris S, Isaacson K. Endometrial thickness measurements among Asherman syndrome patients prior to embryo transfer. Human Reproduction. 2020;35(12):2746-2754. https://doi.org/10.1093/humrep/deaa273
Gkrozou F, Dimopoulou C, Prapas Y, Siristatidis C. In women with chronic or subclinical endometritis is hysteroscopy suitable for setting the diagnosis? A systematic review. Journal of Obstetrics and Gynaecology Research. 2020;46(9):1639-1650. https://doi.org/10.1111/jog.14352
Xiong Y, Chen Q, Chen C, Tan J, Wang Z, Gu F, Xu Y. Impact of oral antibiotic treatment for chronic endometritis on pregnancy outcomes in the following frozen-thawed embryo transfer cycles of infertile women: a cohort study of 640 embryo transfer cycles. Fertility and Sterility. 2021;116(2):413-421. https://doi.org/10.1016/j.fertnstert.2021.03.036
McQueen DB, Bernardi LA, Stephenson MD. Redefining chronic endometritis: the importance of endometrial stromal changes. Fertility and Sterility. 2021;116(3):855-861. https://doi.org/10.1016/j.fertnstert.2021.05.003
Ryan E, Tolani AT, Zhang J, Cruz GI, Folkins AK, Lathi RB.The menstrual cycle phase impacts the detection of plasma cells and the diagnosis of chronic endometritis in endometrial biopsy specimens. Fertility and Sterility. 2022;118(4):787-794. https://doi.org/10.1016/j.fertnstert.2022.07.011
Buzzaccarini G, Vitagliano A, Andrisani A, Santarsiero CM, Cicinelli R, Nardelli C, Ambrosini G, Cicinelli E. Chronic endometritis and embryo implantation failure: a unified pathophysiological theory from a systematic review of the literature. Journal of Assisted Reproduction and Genetics. 2020;37(12):2897-2911. https://doi.org/10.1007/s10815-020-01955-8
Vitagliano A, Saccardi C, Noventa M, Di Spiezio Sardo A, Saccone G, Cicinelli E, Pizzi S, Andrisani A, Litta PS. Effects of chronic endometritis therapy on in vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis. Fertility and Sterility. 2018;110(1):103-112.e1. https://doi.org/10.1016/j.fertnstert.2018.03.017
Vitagliano A, Laganà AS, De Ziegler D, Cicinelli R, Santarsiero CM, Buzzaccarini G, Chiantera V, Cicinelli E, Marinaccio M. Chronic endometritis in infertile women: impact of untreated disease, plasma cell count and antibiotic therapy on IVF outcome — a systematic review and meta-analysis. Diagnostics (Basel). 2022; 12(9):2250. https://doi.org/10.3390/diagnostics12092250
S Mackens, S Loreti, E Goyens, M De Vos, H Tournaye, E Somigliana, N De Munck, C Blockeel. From mathematical modeling to real-life clinical data: live birth rates up until the tenth blastocyst transfer without PGT-A. Human Reproduction. 2023;38(Suppl 1):dead093.172. https://doi.org/10.1093/humrep/dead093.172
Capmas P, Suarhana E, Tulandi T. Management of hydrosalpinx in the era of assisted reproductive technology: A systematic review and meta-analysis. Journal of Minimally Invasive Gynecology. 2021; 28(3):418-441. https://doi.org/10.1016/j.jmig.2020.08.017
Piltonen TT, Komsi E, Morin-Papunen LC, Korhonen E, Franks S, Järvelin MR, Arffman RK, Ollila MM. AMH as part of the diagnostic PCOS workup in large epidemiological studies. European Journal of Endocrinology. 2023;188(6):547-554. https://doi.org/10.1093/ejendo/lvad065
Tang K, Wu L, Luo Y, Gong B. In vitro fertilization outcomes in women with polycystic ovary syndrome: A meta-analysis. European Journal of Obstetrics, Gynecology, And Reproductive Biology. 2021;259(4):146-152. https://doi.org/10.1016/j.ejogrb.2021.02.023
Busnelli A, Beltratti C, Cirillo F, Bulfoni A, Lania A, Levi-Setti PE. Impact of thyroid autoimmunity on assisted reproductive technology outcomes and ovarian reserve markers: an updated systematic review and meta-analysis. Thyroid. 2022;32(9):1010-1028. https://doi.org/10.1089/thy.2021.0656
Zhang Y, Peng J, Liu Y, Wu W, Wang X, Jia L, Guan Y. The impact of high-normal TSH levels on reproductive outcomes in women undergoing ART treatment: a systematic review and meta-analysis. Reproductive Sciences. 2022;29(9): 2440-2451. https://doi.org/10.1007/s43032-021-00594-3
ESHRE Working Group on Recurrent Implantation Failure; Cimadomo D, de Los Santos MJ, Griesinger G, Lainas G, Le Clef N, McLernon DJ, Montjean D, Toth B, Vermeulen N, Macklon N. ESHRE good practice recommendations on recurrent implantation failure. Human Reproduction Open. 2023; 2023(3):hoad023. https://doi.org/10.1093/hropen/hoad023
Koot YEM, Hviid Saxtorph M, Goddijn M, de Bever S, Eijkemans MJC, Wely MV, van der Veen F, Fauser BCJM, Macklon NS. What is the prognosis for a live birth after unexplained recurrent implantation failure following IVF/ICSI? Human Reproduction. 2019; 34(10):2044-2052. https://doi.org/10.1093/humrep/dez120
Bellver J, Simón C. Implantation failure of endometrial origin: what is new? Current Opinion in Obstetrics and Gynecology. 2018;30(4): 229-236. https://doi.org/10.1097/GCO.0000000000000461
Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A. Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis. Human Reproduction. 2023;38(Suppl 1):dead093.234. https://doi.org/10.1093/humupd/dmad010
Van de Vijver A, Polyzos NP, Van Landuyt L, Mackens S, Stoop D, Camus M, De Vos M, Tournaye H, Blockeel C. What is the optimal duration of progesterone administration before transferring a vitrified-warmed cleavage stage embryo? A randomized controlled trial. Human Reproduction. 2016;31(5):1097-1104. https://doi.org/10.1093/humrep/dew045
Van de Vijver A, Drakopoulos P, Polyzos NP, Van Landuyt L, Mackens S, Santos-Ribeiro S, Vloeberghs V, Tournaye H, Blockeel C. Vitrified-warmed blastocyst transfer on the 5th or 7th day of progesterone supplementation in an artificial cycle: a randomised controlled trial. Gynecological Endocrinology. 2017;33(10):783-786. https://doi.org/10.1080/09513590.2017.1318376
Roelens C, Santos-Ribeiro S, Becu L, Mackens S, Van Landuyt L, Racca A, De Vos M, van de Vijver A, Tournaye H, Blockeel C. Frozen-warmed blastocyst transfer after 6 or 7 days of progesterone administration: impact on live birth rate in hormone replacement therapy cycles. Fertility and Sterility. 2020;114(1):125-132. https://doi.org/10.1016/j.fertnstert.2020.03.017
Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, Coomarasamy A. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Human Reproduction Update. 2019;25(2):202-223. https://doi.org/10.1093/humupd/dmy044
Coutifaris C, Myers ER, Guzick DS, Diamond MP, Carson SA, Legro RS, McGovern PG, Schlaff WD, Carr BR, Steinkampf MP, Silva S, Vogel DL, Leppert PC. Histological dating of timed endometrial biopsy tissue is not related to fertility status. Fertility and Sterility. 2004;82(5):1264-1272. https://doi.org/10.1016/j.fertnstert.2004.03.069
Young SL. Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity. Reproductive Biomedicine Online. 2013;27(5):497-505. https://doi.org/10.1016/j.rbmo.2013.06.010
Аганезов С.С., Кузьмина А.В., Эллиниди В.Н., Гогичашвили, К.Э., Аганезова, Н.В. Экспрессия рецепторов эстрогенов и прогестерона в эндометрии у женщин с нарушениями репродуктивной функции при различной функциональной активности желтого тела яичника. Гинекология. 2021;23(6):516-523.
Quinn KE, Matson BC, Wetendorf M, Caron KM. Pinopodes: Recent advancements, current perspectives, and future directions. Molecular And Cellular Endocrinology. 2020;501:110644. https://doi.org/10.1016/j.mce.2019.110644
Machtinger R, Laurent LC, Baccarelli AA. Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation. Human Reproduction Update. 2016;22(2):182-193. https://doi.org/10.1093/humupd/dmv055
Мелкозерова О.А., Чистякова Г.Н., Брагина Е.Е., Гришкина А.А., Щедрина И.Д. Ультраструктурная характеристика покровного эпителия эндометрия в период «окна имплантации» у здоровых женщин и пациенток с репродуктивными неудачами. Морфология 2020;157(1):48-54.
Margioula-Siarkou C, Prapas Y, Petousis S, Milias S, Ravanos K, Kalogiannidis I, Mavromatidis G, Haitoglou C, Prapas N, Rousso D. LIF and LIF-R expression in the endometrium of fertile and infertile women: A prospective observational case-control study. Molecular Medicine Reports. 2016;13(6):4721-4728. https://doi.org/10.3892/mmr.2016.5142
Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, Simón C. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertility and Sterility. 2011;95(1):50-60.e15. https://doi.org/10.1016/j.fertnstert.2010.04.063
Clemente-Ciscar M, Ruiz-Alonso M, Simón C. Endometrial receptivity analysis (ERA) using a next generation sequencing (NGS) predictor improves reproductive outcome in recurrent implantation failure (RIF) patients when compared to ERA arrays. Human Reproduction. 2018;33:8.
Haouzi D, Mahmoud K, Fourar M, Bendhaou K, Dechaud H, De Vos J, Rème T, Dewailly D, Hamamah S. Identification of new biomarkers of human endometrial receptivity in the natural cycle. Human Reproduction. 2008;24:198-205. https://doi.org/10.1093/humrep/den360
Enciso M, Carrascosa JP, Sarasa J, Martínez-Ortiz PA, Munné S, Horcajadas JA, Aizpurua J. Development of a new comprehensive and reliable endometrial receptivity map (ER Map/ER Grade) based on RT-qPCR gene expression analysis. Human Reproduction. 2018; 33(2):220-228. https://doi.org/10.1093/humrep/dex370
Altmäe S, Koel M, Võsa U, Adler P, Suhorutšenko M, Laisk-Podar T, Kukushkina V, Saare M, Velthut-Meikas A, Krjutškov K, Aghajanova L, Lalitkumar PG, Gemzell-Danielsson K, Giudice L, Simón C, Salumets A. Meta-signature of human endometrial receptivity: A meta-analysis and validation study of transcriptomic biomarkers. Scientific Reports. 2017;7(1):10077. https://doi.org/10.1038/s41598-017-10098-3
Evans J, Salamonsen LA, Winship A, Menkhorst E, Nie G, Gargett CE, Dimitriadis E. Fertile ground: Human endometrial programming and lessons in health and disease. Nature Reviews. Endocrinology. 2016;12(11):654-667. https://doi.org/10.1038/nrendo.2016.116
Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C. The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertility and Sterility. 2013;100(3):818-824. https://doi.org/10.1016/j.fertnstert.2013.05.004
Simón C, Gómez C, Cabanillas S, Vladimirov I, Castillón G, Giles J, Boynukalin K, Findikli N, Bahçeci M, Ortega I, Vidal C, Funabiki M, Izquierdo A, López L, Portela S, Frantz N, Kulmann M, Taguchi S, Labarta E, Colucci F, Mackens S, Santamaría X, Muñoz E, Barrera S, García-Velasco JA, Fernández M, Ferrando M, Ruiz M, Mol BW, Valbuena D. A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF. Reproductive Biomedicine Online. 2020;41(3):402-415. https://doi.org/10.1016/j.rbmo.2020.06.002
Ohara Y, Matsubayashi H, Suzuki Y, Takaya Y, Yamaguchi K, Doshida M, Takeuchi T, Ishikawa T, Handa M, Miyake T, Takiuchi T, Kimura T. Clinical relevance of a newly developed endometrial receptivity test for patients with recurrent implantation failure in Japan. Reproductive Medicine and Biology. 2022;21(1):e12444. https://doi.org/10.1002/rmb2.12444
Cozzolino M, Diáz-Gimeno P, Pellicer A, Garrido N. Use of the endometrial receptivity array to guide personalized embryo transfer after a failed transfer attempt was associated with a lower cumulative and per transfer live birth rate during donor and autologous cycles. Fertility and Sterility. 2022;118(4):724-736. https://doi.org/10.1016/j.fertnstert.2022.07.007
Arian SE, Hessami K, Khatibi A, To AK, Shamshirsaz AA, Gibbons W. Endometrial receptivity array before frozen embryo transfer cycles: A systematic review and meta-analysis. Fertility and Sterility. 2023;119(2):229-238. https://doi.org/10.1016/j.fertnstert.2022.11.012
Doyle N, Jahandideh S, Hill MJ, Widra EA, Levy M, Devine K. Effect of timing by endometrial receptivity testing vs standard timing of frozen embryo transfer on live birth in patients undergoing in vitro fertilization: A randomized clinical trial. JAMA. 2022; 328(21):2117-2125. https://doi.org/10.1001/jama.2022.20438
Richter KS, Richter ML. Personalized embryo transfer reduces success rates because endometrial receptivity analysis fails to accurately identify the window of implantation. Human Reproduction. 2023; 38(7):1239-1244. https://doi.org/10.1093/humrep/dead083