The role of the mechanisms of anoikis and autophagy in the pathogenesis of endometriosis (a review)

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Endometriosis is one of the most common and mysterious gynecological diseases. Despite the fact that for more than 150 years scientists from all over the world have explored various hypotheses in search of the culprits of this disease, its etiology and pathogenesis to this day remain poorly understood. Endometriosis is associated with increased survival of endometrial cells, which normally undergo programmed cell death (apoptosis) by the type of anoikis. In turn, one of the mechanisms that affect anoikis may be autophagy. Thus, inhibition of autophagy and disturbance of the regulation of anoikis can serve as one of the factors of the emergence and development of endometriosis.

Keywords:

anoikis

apoptosis

autophagy

endometriosis

Authors:

Adamyan L.V.

Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

Asaturova A.V.

V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia

Stepanian A.A.

Kafedpa peppoduktivnoĭ meditsiny i xipupgii Mockovckogo univepciteta meditsiny i ctomatologii

Popryadukhin A.Yu.

Federal State Budget Institution «Research Center for Obstetris, Gynecology and Perinatology», Moscow, Russia, 117997

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