Objective — to assess the impact of fat metabolism disorders (FMD) in men of reproductive age on a standard macroscopic parameters of the ejaculate (volume, viscosity, pH, liquefaction, concentration of spermatozoa in 1 ml, total number of sperm in ejaculate, number of alive spermatozoa, number of sperm with progressive motility and number of morphologically normal spermatozoa) and abnormalities in the structure of head, neck and middle piece, flagellum of spermatozoa. Material and methods. The study included 607 patients aged 19 to 63, who applied to the Department of artificial reproductive technologies (ART) in Endocrinology Research Centre with complaints of non-occurrence of pregnancy in marriage. All men were categorized according to BMI in three groups. Semiological analysis (WHO criteria, 2010) was performed for all patients. Assessment of sperm morphology was performed according to Kruger criteria. Results. Men with obesity had decreasing number of spermatozoa in 1 ml of ejaculate, decrease in proportion of gametes with progressive motility and normal morphology, and increase of immobile gametes. In addition, there is an increase of gametes with specific pathologies of head, as well as neck defects in ejaculate. Conclusions. There is deterioration in the macroscopic parameters of ejaculate in men with FMD.