AlphaB-crystallin expression in eutopic and ectopic endometrium among the patients with peritoneal form endometriosis: pregnancy outcome

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Objectives. To study the alphaB-crystallin expression and angiogenic level in eutopic and ectopic endometrium in women with endometriosis and to estimate the influence of revealed changes on pregnancy. Material and methods. Immunohistochemistry was used to investigate the alphaB-crystallin expression and angiogenic level in eutopic and ectopic endometrium among the women with endometriosis. AlphaB-crystallin, VEGF-A, sVEGF R1 concentrations in blood and in peritoneal fluid ere measured with the help of ELISA. The pregnancy outcome in patients with endometriosis was accessed in 6 months after the end of the treatment. Immunohistochemistry and ELISA data were compared in women in patients with endometriosis and healthy women with and without pregnancy. Results. AlphaB-crystallin expression in glandular epithelium of eutopic endometrium was lower in patients with endometriosis without pregnancy compared with healthy women and patients with pregnancy. AlphaB-crystallin levels in patients with endometriosis and pregnancy were similar to healthy women. AlphaB-crystallin can be used as biomarker of endometrial receptivity in patients with endometriosis and predict pregnancy outcomes. Conclusion. AlphaB-crystallin level can be used for endometrial receptivity assessment and pregnancy outcomes prediction in patients with endometriosis.

Keywords:

endometriosis

infertility

eutopic endometrium

alphaB-crystallin

pregnancy outcome

Authors:

Burlev V.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Il'iasova N.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

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