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Ivanova L.B.

FGU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. V.I. Kulakova", Moskva

Karamysheva V.I.

FGU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. V.I. Kulakova", Moskva

Perfilova V.N.

FGU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. V.I. Kulakova", Moskva

Tyurenkov I.N.

Volgograd State Medical University, Volgograd, Russia

The EFFECT OF GABA-DERIVATIVES ON ENDOTHELIAL FUNCTION IN RATS WITH EXPERIMENTAL PREECLAMPSIA

Authors:

Ivanova L.B., Karamysheva V.I., Perfilova V.N., Tyurenkov I.N.

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Journal: Russian Journal of Human Reproduction. 2012;(1): 28‑30

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To cite this article:

Ivanova LB, Karamysheva VI, Perfilova VN, Tyurenkov IN. The EFFECT OF GABA-DERIVATIVES ON ENDOTHELIAL FUNCTION IN RATS WITH EXPERIMENTAL PREECLAMPSIA. Russian Journal of Human Reproduction. 2012;(1):28‑30. (In Russ.)

 
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The use of experimental model showed that GABA-derivatives have protective action on endothelium in preeclampsia. The RGPY-189, RGPY-147 and sulodexide prevent the endothelial dysfunction and promote the vasodilatation.

Keywords:

preeclampsia
endothelial dysfunctio

Authors:

Ivanova L.B.

FGU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. V.I. Kulakova", Moskva

Karamysheva V.I.

FGU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. V.I. Kulakova", Moskva

Perfilova V.N.

FGU "Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. V.I. Kulakova", Moskva

Tyurenkov I.N.

Volgograd State Medical University, Volgograd, Russia

List of references:

  1. Bloshchinskaya I.A., Petrichko T.A., Davidovich I.M. Vazoreguliruyushchaya funktsiya sosudistogo endoteliya pri fiziologicheskoi beremennosti i gestoze. Zhurn akush i zhen bol 2003; 52: 1: 26-32.
  2. Gomazkov O.A. Molekulyarnye i fiziologicheskie aspekty endotelial'noi disfunktsii. Rol' endogennykh khimicheskikh regulyatorov. Uspekhi fiziol nauk 2000; 31: 4: 48-59.
  3. Zabolotnov V.A., Rybalka A.N., Zakut R.P., Korshakova N.Yu. Vedenie beremennykh gruppy riska po vozniknoveniyu OPG-gestoza. Reproduktivnoe zdorov'e zhenshchiny 2004; 17: 1: 47-49.
  4. Krasnopol'skii V.I., Logutova L.S., Petrukhin V.A. i dr. Diagnostika i prognozirovanie razvitiya tyazhelykh form gestoza u beremennykh. Ros vestn akush-gin 2006; 1: 69-72.
  5. Perfilova V.N., Tyurenkov I.N., Lebedeva S.A., Berestovitskaya V.M., Vasil'eva O.S. Regional'noe krovoobrashchenie i mikrotsirkulyatsiya 2006; 2: 18: 78-81.
  6. Robertus A.I., Voronkov A.V. Izuchenie antitromboticheskoi aktivnosti proizvodnogo GAMK RGPU-189 v usloviyakh endotelial'noi disfunktsii pri eksperimental'no vyzvannoi nedostatochnosti polovykh gormonov. Vestn RGMU 2010; 2:542 (spets. vypusk).
  7. Strizhakov A.N., Ignatko I.V. Diagnosticheskoe i prognosticheskoe znachenie issledovaniya vnutriplatsentarnogo krovotoka u beremennykh s gestozom. Akush i gin 1997; 2: 13-19.
  8. Tokova Z.Z., Frolova O.G. Gestoz i materinskaya letal'nost'. Ros vestn akush gin 2005; 3: 52-55.
  9. Tyurenkov I.N., Perfilova V.N. Kardiovaskulyarnye i kardio­protektornye svoistva GAMK. Volgograd: VolGMU 2008; 203.
  10. Tyurenkov I.N., Voronkov A.V., Robertus A.I., Voskresenskii S.A., Kurkin D.V. Dopplerograficheskoe izuchenie endotelial'noi disfunktsii tserebral'nykh sosudov krys pri nedostatochnosti polovykh gormonov. Regional'noe krovoobrashchenie i mikrotsirkulyatsiya 2007; 21: 1: 175-176.
  11. Tyurenkov I.N., Voronkov A.V., Robertus A.I., Slietsans A.A., Petrova E.V., Kurkin D.V. Endotelioprotektivnoe deistvie strukturnykh analogov GAMK. Sbornik nauchnykh trudov. Pod red. V.I. Petrova. Volgograd: VolgMU 2009; 289-291.
  12. Beausejour A., Auger K., St-Louis J., Brochu M. High-sodium intake prevents pregnancy-induced decrease of blood pressure in the rat. Am J Physiol Heart Circ Physiol 2003; 285: 375-383.
  13. Canbakan V., Keven K., Tutkak H., Danisman N., Ergun I., Nergizoglu G. Circulating endothelial cells in Preeclampsia. J Human Hypertens 2007; 21: 558-563.
  14. Armitage J.A., Ishibashi A., Balachandran A.A., Jensen R.I., Poston L., Taylor P.D. Programmed aortic dysfunction and reduced Na+,K+-ATPase activity present in first generation offspring of lard-fed rats does not persist to thesecond generation. Exp Physiol 2007; 92: 3: 583-589.

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