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Abdulvapova Z.N.

Endocrinology Research Centre, Moscow, Russian Federation

Artemova E.V.

Federal state budgetary institution «Endocrinological Research Centre», Russian Ministry of Health, Moscow

Gorbacheva A.M.

Lomonosov Moscow State University, Moscow, Russian Federation

Galstian G.R.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr", Moskva

Tokmakova A.Iu.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" MZ RF

Gavrilova S.A.

Lomonosov Moscow State University, Moscow, Russia

Phenotyping animal models of diabetic peripheral neuropathy in rats: advantages and limitations

Authors:

Abdulvapova Z.N., Artemova E.V., Gorbacheva A.M., Galstian G.R., Tokmakova A.Iu., Gavrilova S.A.

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Journal: Problems of Endocrinology. 2018;64(3): 188‑193

DOI: 10.14341/probl9284

Read: 1406 times

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Table of contents

PHENOTYPING ANIMAL MODELS OF DIABETIC PERIPHERAL NEUROPATHY IN RATS: ADVANTAGES AND LIMITATIONS
PHENOTYPING ANIMAL MODELS OF DIABETIC PERIPHERAL NEUROPATHY IN RATS: ADVANTAGES AND LIMITATIONS

To cite this article:

Abdulvapova ZN, Artemova EV, Gorbacheva AM, Galstian GR, Tokmakova AIu, Gavrilova SA. Phenotyping animal models of diabetic peripheral neuropathy in rats: advantages and limitations. Problems of Endocrinology. 2018;64(3):188‑193. (In Russ.)
https://doi.org/10.14341/probl9284

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Abstract:

Diabetic polyneuropathy is one of the most common late complications of diabetes mellitus, as well as the main cause of ulcerative foot defects. The prevalence of neuropathy among people with diabetes varies from 28 to 65%, depending on the disease duration and diagnostic features. Initial signs of damage are detected as early as in prediabetes. To date, there is a fairly limited knowledge of the mechanisms of nerve fiber damage in diabetes. Also, it is unclear which type of nerve fibers is involved in damage first and how the nervous system regulates repair of tissues and local immunity. Animal models of diabetic peripheral neuropathy enable studying new aspects of the pathogenesis of this common diabetes complication and open prospects for the search and development of new drugs.

Keywords:

diabetes mellitus
rats
diabetic peripheral neuropathy
neuropathy assessment

Authors:

Abdulvapova Z.N.

Endocrinology Research Centre, Moscow, Russian Federation

Artemova E.V.

Federal state budgetary institution «Endocrinological Research Centre», Russian Ministry of Health, Moscow

Gorbacheva A.M.

Lomonosov Moscow State University, Moscow, Russian Federation

Galstian G.R.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr", Moskva

Tokmakova A.Iu.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" MZ RF

Gavrilova S.A.

Lomonosov Moscow State University, Moscow, Russia

Close metadata

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