Features of molecule expression markers of insulin resistance in experimental Alzheimer’s disease

Gorina Ya.V.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Komleva Yu.K.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Lopatina O.L.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Volkova V.V.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Gersog G.E.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Popova N.N.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Salmina A.B.

Kafedra biologicheskoĭ khimii s kursami meditsinskoĭ farmatsevticheskoĭ i toksikologicheskoĭ khimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo, NII molekuliarnoĭ meditsiny i patobiokhimii, Krasnoiarsk

Features of molecule expression markers of insulin resistance in experimental Alzheimer’s disease

Authors:

Gorina Ya.V., Komleva Yu.K., Lopatina O.L., Volkova V.V., Gersog G.E., Popova N.N., Salmina A.B.

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Journal: Problems of Endocrinology. 2015;61(4): 43‑48

DOI: 10.14341/probl201561443-48

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To cite this article:

Gorina YaV, Komleva YuK, Lopatina OL, Volkova VV, Gersog GE, Popova NN, Salmina AB. Features of molecule expression markers of insulin resistance in experimental Alzheimer’s disease. Problems of Endocrinology. 2015;61(4):43‑48. (In Russ.)
https://doi.org/10.14341/probl201561443-48

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Alzheimer’s Disease (AD) is characterized by a significant loss of neurons and synapses, especially in the hippocampus and cortex, the extracellular β-amyloid accumulation and formation of neurofibrillary tangles. Insulin resistance plays important role in neurodegeneration and cognitive disorders in the central nervous system, especially AD. However, the cellular and molecular mechanisms that connect insulin resistance and Alzheimer’s pathogenesis remain largely unexplained. Therefore, great importance is the identification of molecular markers that allow to define new approaches to targeted pharmacological correction of neurodegeneration. This article describes the study of the expression of molecular markers, namely, IRAP, GLUT4, and IL-18 in different brain regions (hippocampus, olfactory bulb) rats with experimental AD.

Keywords:

molecular markers

insulin resistance

neurodegeneration

insulin-regulated aminopeptidase

GLUT4

IL-18

Authors:

Gorina Ya.V.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Komleva Yu.K.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Lopatina O.L.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Volkova V.V.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Gersog G.E.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Popova N.N.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

Salmina A.B.

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