Carbohydrate metabolism in the patients presenting with polycystic ovary syndrome

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This study with the participation of 117 patients was designed to characterize the clinical picture of polycystic ovary syndrome (POS), the state of carbohydrate metabolism, blood androgen and insulin levels. Impaired glucose tolerance was documented in 42 (36%) of the patients. Type 2 diabetes mellitus was diagnosed in one of them (0.9%). The occurrence of the normal and excessive body weight was unrelated to normal and impaired glucose tolerance. The same is true of the frequency of hyperinsulinemia even though abnormal insulin resistance indices and marked hyperinsulinemia were most frequently recorded in the patients having body mass index (BMI) in excess of 25. BMI was shown to directly correlate with the blood androgen level and the severity of manifestations of hirsutism. The study has demonstrated the necessity of estimating the state of carbohydrate metabolism in all the patients presenting with polycystic ovary syndrome for the timely prescription of pathogenetic therapy.

Keywords:

polycystic ovary syndrome

body mass index

hyperinsulinemia

impaired glucose tolerance

androgens

hirsutism

Authors:

Soboleva E.L.

FGBU "NII akusherstva i ginekologii im. D.O. Otta" SZO RAMN, Sankt-Peterburg

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